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research Design, Synthesis, and Biological Characterization of Metabolically Stable Selective Androgen Receptor Modulators

129 citations , January 2004 in “Journal of medicinal chemistry”

This study synthesized nonsteroidal ligands as second-generation androgen receptor agonists and identified three compounds with significant anabolic activity and moderate to minimal androgenic activity in vivo.

research Improving selective androgen receptor modulator discovery and preclinical evaluation

11 citations , August 2009 in “Expert Opinion on Drug Discovery”

This review discusses current challenges in selective androgen receptor modulator discovery and preclinical evaluation and reports no new results, emphasizing the need for basic research to improve safety and selectivity.

research Abstract P5-09-21: Selective androgen receptor modulators (SARMs): Enobosarm as targeted therapy for the treatment of androgen receptor-positive breast cancer

2 citations , December 2013 in “Cancer research”

In this study, GTx-027, a selective androgen receptor modulator, significantly inhibited tumor growth in certain breast cancer models and showed good tolerance in a Phase II trial with postmenopausal women.

research Androgen receptor modulators: a review of recent patents and reports (2012-2018)

23 citations , May 2019 in “Expert Opinion on Therapeutic Patents”

This review discusses AR-modulating agents developed between 2012 and 2018, highlighting challenges with ligand-binding domain antagonists and proposing nonconventional approaches targeting other domains as promising strategies.

research A comprehensive investigation into the molecular mechanism responsible for selective androgen receptor (SARM) tissue-selectivity

January 2008 in “OhioLink ETD Center (Ohio Library and Information Network)”

This study found evidence of structurally and functionally distinct AR-SARM protein complexes, which may contribute to understanding how SARMs achieve tissue-selective effects.

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Community Join

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community Androsterone as a Neurosteroid Replacement Strategy for 5α-Reductase Inhibitor–Associated Sexual and Affective Dysfunction

in Research/Science 36 upvotes 2 months ago

Androsterone may help with sexual and affective dysfunction from finasteride by replacing disrupted neurosteroids without increasing androgenic side effects. Controlled testing is needed to confirm its effectiveness and safety.

community 200 days on dut + min, what do you think?

599 upvotes 11 months ago

The user reports significant hair regrowth after 200 days using dutasteride and minoxidil, attributing changes to hair dye. Others doubt the authenticity and discuss treatment effectiveness and side effects.

community PSA: Most men who stay on Fin will see the sexual side effects go away. Stop the fear mongering

192 upvotes 4 years ago

Finasteride can cause sexual side effects in less than 2% of men, but these often disappear over time, even if the treatment continues. Some users report persistent side effects, while others experience no issues or only temporary ones.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 1 year ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community The story of RU58841/ PSK3841

in Research 622 upvotes 2 years ago

RU58841, a potential hair loss treatment, was not commercialized due to marketability issues and lack of long-term safety data. Concerns about its formulation and delivery methods further complicate its use.

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Experts

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Hair Transplant Surgeon
Dr. Shashikiran AR, MD, MBBS, FRGHS
Mysuru, Karnataka, India

Clinics

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Dr. Shashikiran AR, MD, MBBS, FRGHS