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research Diffusion properties of model compounds in artificial sebum

29 citations , May 2007 in “International journal of pharmaceutics”

This study found that drug transport through artificial sebum varies depending on the compound, suggesting that sebum-targeted delivery can be optimized by selecting compounds based on their distinct transport profiles in sebum versus skin.

research Comparison of artificial sebum with human and hamster sebum samples

49 citations , September 2008 in “International journal of pharmaceutics”

This study suggests that artificial sebum L may serve as an effective substitute for human sebum in drug transport studies, due to its similar physicochemical properties.

research Determination of Solute Diffusion Properties in Artificial Sebum

6 citations , May 2019 in “Journal of pharmaceutical sciences”

This study found that diffusion coefficients of chemicals in artificial sebum are significantly higher than those in stratum corneum lipids, suggesting the hair follicle may significantly contribute to transdermal permeation.

research Ozone interactions with human hair: Ozone uptake rates and product formation

93 citations , February 2008 in “Atmospheric environment”

In this study, researchers found that human scalp hair, particularly when unwashed, can significantly react with ozone, reducing personal ozone exposure and increasing exposure to volatile reaction products.

research 8주 지구성 훈련이 랫 전립선의 자가포식과 전립선비대증에 미치는 영향

January 2019

This study suggests that endurance exercise training may alleviate hormonal and inflammatory factors associated with BPH in rats, although it does not improve autophagy regulation.

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Community Join

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community Androsterone as a Neurosteroid Replacement Strategy for 5α-Reductase Inhibitor–Associated Sexual and Affective Dysfunction

in Research/Science 36 upvotes 2 months ago

Androsterone may help with sexual and affective dysfunction from finasteride by replacing disrupted neurosteroids without increasing androgenic side effects. Controlled testing is needed to confirm its effectiveness and safety.

community Creatine effects on DHT Experiment

57 upvotes 2 years ago

Creatine might increase hair loss due to increased DHT sensitivity, but evidence is mostly anecdotal. The user is using oral minoxidil for hair loss and is cautious about starting creatine.

community Just under a year progress (topical fin/min .3/6%)

in Progress Pictures 612 upvotes 2 years ago

A user shared their positive experience with hair regrowth using topical finasteride and minoxidil, despite initial side effects. They are transitioning to oral finasteride and minoxidil for convenience and are optimistic about continued progress.

community Minoxidil Response Bottlenecks: Why Sulfation and Transport Matter (And Where Tretinoin Fits In)

in Research 461 upvotes 1 year ago

Minoxidil's effectiveness is limited by the need for sulfation and proper transport to hair follicles, with tretinoin potentially enhancing its effects by promoting enzyme activity and keratinocyte differentiation. Tretinoin may improve minoxidil's response by boosting the expression of necessary enzymes and transporters.

community Sebum on scalp has reduced, what gives ?

1 upvotes 7 months ago

The reduction in scalp oiliness is likely due to finasteride reducing DHT levels and the use of ketoconazole shampoo. The combination of these treatments may have decreased sebum production.

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Learn

3 / 4 results

learn Bimatoprost

Can a lash-growth serum like bimatoprost actually work for your scalp? Bimatoprost (Latisse) is FDA-approved only for eyelashes, not the scalp. In the larger of two Allergan phase 2 scalp trials, every bimatoprost formulation gave smaller hair-count gains than minoxidil 5%; the results were posted to ClinicalTrials.gov but never published in a journal, and scalp use remains off-label and experimental.

learn Exosomes

Are exosomes applied as a serum, an injection, or combined with other hair treatments? Clinics offer exosomes as scalp injections, as serums applied after microneedling, or combined with PRP. No exosome product is FDA-approved, and no reliable evidence shows that any of these methods works.

learn Rapamycin

Are there any visible side effects when using rapamycin cream or serum on the scalp? No study has tested rapamycin on the scalp; in facial trials skin reactions were common (64% vs 29% placebo; Aitken et al. 2023, PMID 37463422).

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