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research P382 Scalp fungal microbiome and sebum composition in males with and without androgenetic alopecia

September 2022 in “Medical Mycology”

This study found that patients with androgenic alopecia exhibited higher levels of Malassezia colonization and altered sebum composition compared to individuals without AGA.

research A Comparative Analysis of Serum Irisin Levels and Body Composition Indices in Women With and Without Polycystic Ovary Syndrome (PCOS)

1 citations , October 2024 in “Cureus”

This study reported that women with polycystic ovarian syndrome have higher serum irisin levels, which are associated with metabolic and hormonal imbalances, including hyperandrogenism, total cholesterol, and visceral fat.

research Scalp Microbiome and Sebum Composition in Japanese Male Individuals with and without Androgenetic Alopecia

4 citations , October 2021 in “Microorganisms”

This study suggests that both the sebum composition and microbial imbalance on the scalp may play a role in the development of androgenetic alopecia among Japanese males.

research 1302 Disturbed sebum and microbiome composition in sensitive scalp

April 2018 in “Journal of Investigative Dermatology”

This study found that sensitive scalp is characterized by increased pH levels, redness, altered sebum composition, and a disrupted microbiome, suggesting these features could inform treatment approaches.

research Serum and hair steroid profiles and their associations with body composition in adolescence

November 2025 in “European Journal of Endocrinology”

This study found that hair steroid profiling is a feasible, non-invasive alternative to serum analysis in adolescents, with androgen levels correlating more strongly with body size and composition in boys than girls.

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community DHT Harms Scalp Microbiome: DHT Itch is REAL

413 upvotes 1 year ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

community DHT Itch and Oily Scalp Explained (and how to fix it)

90 upvotes 3 months ago

Malassezia overgrowth can worsen oily scalp and inflammation, contributing to hair loss. Treatments include antifungal shampoos, C6/C8 MCT oil, low-dose isotretinoin, finasteride, and dutasteride.

community Highly experimental stack! Self Study Coming!

6 upvotes 5 months ago

A 19-year-old plans to use an experimental hair loss treatment stack including micro-needling, Minoxidil, Pyrilutamide, Ketoconazole shampoo, and other unreleased compounds like PP405. Users advise against using unverified treatments and suggest sticking to proven options like Finasteride, with some recommending topical application to avoid side effects.

community Anyone on Dutasteride have reduced scalp oil?

in Finasteride/Dutasteride 13 upvotes 1 year ago

Dutasteride may reduce scalp oil and itchiness more effectively than finasteride, with some users experiencing drier skin and improved hair thickness. Users report varying results, with some noticing benefits after switching from finasteride to dutasteride, while others use a combination of treatments including minoxidil.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

63 upvotes 2 years ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Baicapil

Could a daily serum with Baicapil help revive dormant hair follicles before it’s too late? Yes, a daily serum with Baicapil may help revive dormant hair follicles.

learn Bimatoprost

Can a lash-growth serum like bimatoprost actually work for your scalp? Bimatoprost (Latisse) is approved for eyelashes, not the scalp; two Allergan phase 2 trials in men with androgenetic alopecia posted results to ClinicalTrials.gov but were never published in a peer-reviewed journal, so scalp use remains off-label and experimental.

learn Hyaluronic Acid

What’s the difference between using hyaluronic acid as a serum on the scalp versus taking it as a supplement? Hyaluronic acid serum hydrates the scalp surface, while supplements may support overall hair health.

learn Exosomes

Are exosomes applied as a serum, an injection, or combined with other hair treatments? Exosomes are typically injected directly or combined with other hair treatments.

learn Rapamycin

Are there any visible side effects when using rapamycin cream or serum on the scalp? Visible side effects may include skin irritation or redness when using rapamycin on the scalp.

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