High levels of ERK activity are key for tissue regeneration in spiny mice, and activating ERK can potentially redirect scar-forming healing towards regenerative healing in mammals.
Microneedling for hair loss and its potential long-term effects. Some users believe it can cause fibrosis and scartissue if done too frequently or deeply, while others claim it has improved their hair loss when done correctly. There is limited scientific research on the topic.
Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.
Microneedling can help with hair loss by inducing collagen if done correctly, but improper technique may cause scarring and worsen the condition. Some users apply dissolved vitamin C before and after microneedling to enhance results.
Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.
Oral minoxidil may cause facial bloating and dark circles, making some users feel they look older. Some consider reducing the dosage or switching treatments due to these side effects.