January 2025 in “Open Medicine” This study found that high-concentration cell-free adipose extract effectively reduced collagen deposition and blood vessel formation in a rabbit ear model, showing promise for preventing and treating hypertrophic scars.
11 citations
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January 1988 in “PubMed” This study found that epidermal cell extract from keratinocytes may promote epidermal cell proliferation and migration while inhibiting fibroblast activity, potentially reducing scarring in wound healing.
August 2026 in “npj Regenerative Medicine” This study found that hair follicle micro-graft transplantation significantly improved scar remodeling outcomes in 40 patients, with greater reductions in scar volume, lower scar scores, and enhanced skin characteristics compared to punch excision alone, potentially due to activation of the PI3K-AKT pathway.
September 2023 in “International journal of biomedicine” This review evaluated current evidence on minoxidil's potential to treat scars and reported reduced collagen accumulation and fibrosis in various studies, suggesting its antifibrotic effects may benefit wound healing; however, direct studies on acne scars are yet to be conducted.
2 citations
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November 2014 in “International Scholarly Research Notices” This study concluded that while the terpenoid fraction of M. jalapa's root extract increased growth factor expression in wound healing, it may lead to hypertrophic scars by prolonging the proliferation phase.
