research Investigation of Age-Related Decline of Microfibril-Associated Glycoprotein-1 in Human Skin Through Immunohistochemistry Study
MAGP-1 decreases with age, leading to weaker, sagging skin.
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research Effect of 1α,25-Dihydroxyvitamin D3 on Mechanical Properties of Hairless Mouse Skin
Vitamin D3 applied to mouse skin caused more wrinkles and sagging due to changes in the skin's outer layer.
research The Pathobiology of Skin Aging
Skin aging is a complex process influenced by various factors, leading to wrinkles and sagging, and should be considered a disease due to its health impacts.
research Clinical Efficacy of Topical or Oral Soy Supplementation in Dermatology: A Systematic Review
Soy supplements improve various skin conditions and aging signs, with topical use boosting skin barrier function.
research Sweat Glands Shrink Upward With Aging, Causing Dermal Layer Defects Leading to Loss of Skin Elasticity and Wrinkling - Establishment of 3D Imaging Method for Skin Appendages
Aging causes sweat glands to shrink and move upward, leading to less elastic skin and more wrinkles.
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5 / 27 resultscommunity Is 2-deoxy-D-ribose (2dDR) good for human hair?
Topical 2-deoxy-D-ribose (2dDR) regrows hair in mice almost as well as 2% Minoxidil. However, 2dDR may contribute to oxidative stress and hair loss due to the formation of advanced glycation end products (AGEs).
community Finasteride and “anti-aging” effects
Finasteride may help users look younger by suppressing DHT, affecting skin and hair. Users also emphasize skincare, sunscreen, and lifestyle for maintaining a youthful appearance.
community Hair loss journey from 01 24 to 06 25 / HT and 5ARI only
A 28-year-old male shares his hair loss journey, starting with a hair transplant in February 2024 and using finasteride, later switching to dutasteride in January 2025. He has not used minoxidil and is satisfied with the results, despite some side effects like temporary nipple pain and a spike in libido.
community Minoxidil actually reduces wrinkles
Minoxidil may improve or worsen skin quality, with topical forms causing dryness and wrinkles, possibly due to alcohol content, while oral forms have fewer side effects. Some users consider using tretinoin to mitigate negative effects.
community 22M After 3 years of minox and almost 2 on fin, I've got a NW1 and my ideal hair... but my face is fucked/aged from minoxidil and I want to stop it
A user reported significant facial aging after using minoxidil for hair loss, despite a good skincare routine and healthy lifestyle. They plan to switch to dutasteride and possibly stop minoxidil.