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research Hydrogen Sulfide Disturbs Actin Polymerization via S-Sulfhydration Resulting in Stunted Root Hair Growth

75 citations , August 2018 in “Plant physiology”

In this study, researchers found that increased hydrogen sulfide levels in Arabidopsis disrupted actin dynamics through S-sulfhydration, leading to the depolymerization of actin filaments and inhibited root hair growth.

research Ultraviolet‐induced red fluorescence in androgenetic alopecia—indicating alterations in microbial composition

June 2024 in “Skin Research and Technology”

In this study, researchers observed significant differences in microbial composition between UV-induced fluorescent and non-fluorescent scalp areas in patients with androgenetic alopecia, noting a higher abundance of Cutibacterium in the fluorescent regions.

research Human hair keratin responds to oxidative stress via reactive sulfur and supersulfides

April 2024 in “Advances in Redox Research”

In this study, researchers found that polysulfides in human hair keratin contribute to hair strength and antioxidant capacity, with sulfur supplementation enhancing hair strength and cuticle structure amid oxidative stresses such as UV radiation.

research RAPID ALKALINIZATION FACTOR 22 is a key modulator of the root hair growth responses to fungal ethylene emissions in Arabidopsis

7 citations , September 2024 in “PLANT PHYSIOLOGY”

This study in Arabidopsis thaliana found that exposure to volatile compounds from Penicillium aurantiogriseum promotes root hair growth through signaling involving RALF22, ethylene, auxin, and photosynthesis, and that RALF22 plays a crucial role in the plants' response to these compounds.

research Role of S-Palmitoylation by ZDHHC13 in Mitochondrial function and Metabolism in Liver

59 citations , May 2017 in “Scientific reports”

This study found that ZDHHC13 deficiency in mice is associated with abnormal liver function, lipid metabolism issues, and impaired mitochondrial function, highlighting ZDHHC13's regulatory role in liver metabolism.

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learn Meta-bisulfite

learn Botox

What’s the science behind Botox injections for androgenetic alopecia? Small published studies and a 2025 meta-analysis report hair-count gains from scalp botulinum toxin injections, but nearly all of them lack control groups, and reviewers of the same literature call the evidence low-quality; the treatment is off-label and not approved for hair loss anywhere.

learn Glycerin

What’s the difference between vegetable glycerin and synthetic glycerin in hair products? Vegetable glycerin is plant-derived, while synthetic glycerin is petroleum-based, but both are chemically identical.

Community Join

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community What's the proper way to use a derma stamp?

104 upvotes 4 days ago

A user is seeking advice on using a derma stamp for hair loss treatment, alongside minoxidil and finasteride. Recommendations include cleaning the scalp, using alcohol or hypochlorous acid for sterilization, starting with a needle length of 0.5mm, and stamping once a week.

community What's your unpopular opinion?

56 upvotes 6 days ago

Minoxidil is criticized for being inconvenient and ineffective compared to finasteride, with some users experiencing issues like flaking and greasy hair. Alternatives like adenosine are suggested, and the effectiveness of minoxidil can be improved with tretinoin and dietary changes.

community Let’s be real, does infrequent smoking really accelerate MPB and/or cause health issues?

10 upvotes 1 week ago

Smoking infrequently is unlikely to significantly impact hair loss or health, especially when using treatments like finasteride and minoxidil. Genetics play a larger role in hair loss, and low smoking frequency is not considered a major risk.

community How’s my progress? 2 months in - 2.5 mg min, 1 mg fin

21 upvotes 2 weeks ago

The user resumed 2.5 mg oral minoxidil and added 1 mg finasteride, Nizoral 2%, Vitamin D3+K2, and Biotin after noticing hair loss. They are seeing progress and are encouraged by the results after two months.

community Why aren't they researching how to make Minoxidil's effect permanent instead of it weaning off over time?

52 upvotes 3 weeks ago

Minoxidil's effects on hair regrowth diminish over time because it doesn't address the root cause of hair loss, and its mechanism isn't fully understood. Combining it with treatments like finasteride or dutasteride can help maintain its effectiveness, but permanent solutions are unlikely due to the complexity of hair loss biology.

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