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Persistent Escalation of Alcohol Consumption by Mice Exposed to Brief Episodes of Social Defeat Stress: Suppression by CRF-R1 Antagonism

research Persistent escalation of alcohol consumption by mice exposed to brief episodes of social defeat stress: suppression by CRF-R1 antagonism

38 citations , April 2018 in “Psychopharmacology/Psychopharmacologia”

In this study, socially defeated mice showed increased alcohol consumption, and CRF-R1 antagonism selectively reduced drinking in these mice, suggesting a potential treatment target for stress-related alcohol use disorders.

In-Vitro Effect of Sex Steroids on Mouse Melanoma (B16F10) Cell Growth

research <i>In-Vitro</i> Effect of Sex Steroids on Mouse Melanoma (B16F10) Cell Growth

11 citations , January 2014 in “CellBio”

Sex steroids, especially progesterone, can slow down the growth of mouse melanoma cells.

research Sex hormones and related compounds, including hormonal contraceptives

January 2014 in “Side effects of drugs annual”

This review discusses the 2011 publications on the side effects of sex hormones and related compounds, without reporting new clinical results.

research Progesterone promotes the survival of newborn neurons in the dentate gyrus of adult male mice

85 citations , May 2009 in “Hippocampus”

This study found that progesterone enhances the survival of newborn neurons in the hippocampus of adult male mice, which is associated with improved spatial learning and memory.

research Chronic Stress Suppresses the Expression of Cutaneous Hypothalamic–Pituitary–Adrenocortical Axis Elements and Melanogenesis

40 citations , May 2014 in “PLoS ONE”

This study suggests that chronic stress can lead to decreased skin pigmentation in mice by disrupting the skin's HPA axis, potentially making stress a risk factor for depigmentation.

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community If RU58841 is such an effective anti androgen

in Research/Science 46 upvotes 2 years ago

RU58841 is discussed as a topical anti-androgen for hair loss, but its effectiveness and safety are not well-documented, leading to mixed opinions and experiences among users. Some combine it with finasteride, but concerns about side effects and lack of FDA approval limit its popularity.

community I messed up. Regrew my hair and then lost it all.

495 upvotes 1 year ago

Stopping hair loss treatments like finasteride and minoxidil can result in losing regrown hair, highlighting the importance of consistent use. Restarting these treatments may cause temporary shedding, but hair can regrow with continued use.

community Water based carriers and RU-58841

3 upvotes 4 months ago

RU-58841 solutions and their effectiveness for hair loss, with concerns about water-based carriers potentially ruining the compound. Users discuss mixing RU-58841 with alcohol and minoxidil, and experiences vary with some noticing hair loss or shedding.

community RU-58841 users in Canada, what’s your experience?

3 upvotes 4 months ago

RU-58841 users in Canada discuss their experiences, with some reporting positive results and others experiencing side effects. Users also share sources for purchasing RU-58841 and related solvents, with AnagenInc being a common supplier.

community RU and cetosomal minoxidil topical

1 upvotes 7 months ago

Mixing RU58841 with cetosomal minoxidil is discussed due to scalp irritation from ethanol PG vehicles. A mixture of the two turned bright pink when left to dry.

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