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research An organ-on-a-chip approach for investigating root-environment interactions in heterogeneous conditions

April 2017 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study introduced the dual-flow-RootChip platform to demonstrate that Arabidopsis roots exhibit non-autonomous adaptations, such as hair growth regulation, when subjected to varied environmental conditions on opposite sides.

research Dual‐flow‐RootChip reveals local adaptations of roots towards environmental asymmetry at the physiological and genetic levels

80 citations , November 2017 in “New Phytologist”

In this study, the researchers used the dual-flow-RootChip to show that Arabidopsis roots can locally adapt their hair development in response to asymmetric phosphate conditions.

Deciphering the Biological Processes in Root Hairs Required for Nitrogen-Self-Fertilizing Cereals

research Deciphering the biological processes in root hairs required for N-self-fertilizing cereals

December 2023 in “Frontiers in plant physiology”

This review discusses recent findings on how root hairs and root exudate secretion play critical roles in recruiting nitrogen-fixing bacteria, potentially aiding the development of cereal crops that can use atmospheric nitrogen, which may reduce reliance on synthetic fertilizers.

research Dissecting Hierarchies between Light, Sugar and Auxin Action Underpinning Root and Root Hair Growth

31 citations , January 2021 in “Plants”

This study found that light and sucrose have opposing effects on root length but collectively enhance root hair emergence and elongation in plant roots.

research Cell surface receptor kinase FERONIA linked to nutrient sensor TORC signaling controls root hair growth at low temperature linked to low nitrate in Arabidopsis thaliana

44 citations , January 2023 in “New Phytologist”

This study found that low temperature triggers root hair elongation in Arabidopsis thaliana through a FERONIA-ROP2-TORC signaling pathway, also activated by nitrogen deficiency.

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community Why do we get bald from evolutionary perspective

in Chat 213 upvotes 1 year ago

Baldness is not an evolutionary disadvantage because it occurs after reproductive age. Treatments like Minoxidil and Finasteride are used for androgenetic alopecia but don't address the root cause.

community SCUBE3 and GT20029 could be the closet thing to a cure: Hair Follicle Regeneration and Protection Against DHT

14 upvotes 3 years ago

SCUBE3 and GT20029 are potential treatments for hair loss, with SCUBE3 stimulating hair growth and GT20029 protecting against DHT. A combined approach using SCUBE3, finasteride or dutasteride, and later GT20029 could provide a comprehensive treatment for androgenetic alopecia.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

63 upvotes 2 years ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community Study: There is 70x Higher Unconjugated DHT in Feces Compared To Blood Levels in Young Adults - Gut Microbiota Manages DHT Recycling and Metabolism

in Research/Science 194 upvotes 1 year ago

Gut microbiota significantly influences androgen metabolism, impacting hair loss treatments like finasteride. Probiotics, dietary changes, and fecal microbiota transplants may help manage DHT levels and improve hair health.

community A Theory on Why Microneedling Works

175 upvotes 6 years ago

Microneedling may enhance hair regrowth by transferring stem cells to dormant follicles, improving the effects of minoxidil. Users discuss using microneedling with needle lengths around 1.5mm to stimulate hair growth.

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