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Did you mean Rho-associated protein kinase?

GlossaryRho kinase (Rho-associated protein kinase)

enzyme regulating cell shape and movement via the cytoskeleton

Rho kinase, often abbreviated as ROCK, is an enzyme that plays a crucial role in regulating the shape and movement of cells by affecting the cytoskeleton, which is the cell's structural framework. It is involved in various cellular functions, including contraction, motility, proliferation, and apoptosis, and has been implicated in conditions like hypertension, cancer, and certain types of hair loss, such as alopecia.

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Short-Term Rho-Associated Kinase Inhibitor Treatment Accelerates Primary Keratinocyte Growth Without Affecting the Stem Cell Population

research Short-Term Rho-Associated Kinase Inhibitor Treatment Accelerates Primary Keratinocyte Growth Without Affecting the Stem Cell Population

November 2022 in “Journal of Investigative Dermatology”

Short-term treatment with ROCKi increases skin cell growth without changing stem cell features.

research Establishment of an Efficient Primary Culture System for Human Hair Follicle Stem Cells Using the Rho-Associated Protein Kinase Inhibitor Y-27632

16 citations, March 2021 in “Frontiers in cell and developmental biology”

A new method using Y-27632 improves the growth and quality of human hair follicle stem cells for tissue engineering and therapy.

research IL-9 Mediated Human Primary Keratinocytes Invasion Is Dependent on MLC Controlled Contractility and Independent of MMP Activity

April 2018 in “Journal of Investigative Dermatology”

IL-9 increases skin cell movement but decreases their ability to invade, and this effect is controlled by cell contractility, not by MMPs.

research The Role of Lysophosphatidic Acid in the Physiology and Pathology of the Skin

24 citations, December 2018 in “Life sciences”

Lysophosphatidic acid is important for skin health and disease, and could be a target for new skin disorder treatments.

research Folliculin Interacts With P0071 (Plakophilin-4) and Deficiency Is Associated With Disordered RhoA Signalling, Epithelial Polarization, and Cytokinesis

47 citations, September 2012 in “Human molecular genetics online/Human molecular genetics”

Folliculin deficiency causes problems with cell division and positioning due to disrupted RhoA signaling and interaction with p0071.

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community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.