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research DGAT1 Modulates Hair Cycling and Is Essential for Retinoid Homeostasis in the Skin

June 2007

This study found that the enzyme encoded by Dgat1 acts as a retinol acyltransferase in murine epidermis, protecting against retinoid toxicity and alopecia by preventing retinol accumulation.

research The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters

258 citations , July 2005 in “Journal of lipid research”

This study found that DGAT1 exhibits additional acyltransferase activities in vitro, including MGAT, wax synthase, and ARAT activities, suggesting these could be relevant to its in vivo functions.

research Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin

91 citations , November 2008 in “Journal of biological chemistry/The Journal of biological chemistry”

This study found that DGAT1 functions as a key enzyme in murine skin to regulate retinoic acid levels and prevent retinoid toxicity, impacting hair cycle and sensitivity to retinol.

research Epidermal retinol dehydrogenases cyclically regulate stem cell markers and clock genes and influence hair composition

April 2024 in “Communications biology”

The researchers reported that disrupting ATRA signaling by deleting RDHE genes in the hair follicle led to altered hair follicle cycles, composition, and gene expression, indicating RDHEs' role in hair follicle signaling coordination.

research Serotoninergic and melatoninergic systems are fully expressed in human skin

249 citations , April 2002 in “The FASEB journal”

This study provides evidence that human skin contains genes and enzymes necessary for producing serotonin and melatonin.

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Does retinol improve scalp health or help other hair growth treatments work? No trial has tested over-the-counter retinol for hair; the studies used prescription tretinoin (retinoic acid), mostly in the lab, with mixed results. Retinoids need caution in pregnancy, so ask a doctor first.
Can retinol help enhance the absorption of ingredients like minoxidil or peptides? No human study has measured whether retinol increases scalp absorption of minoxidil or peptides. Retinoids thicken rather than thin the epidermis, and they can irritate skin and need caution in pregnancy.
Is retinol safe to use on the scalp, or should it be diluted to avoid irritation? There is little research on retinol on the scalp; retinoids often cause redness, dryness and peeling, and long-term scalp safety has not been studied. Avoid retinoids if pregnant or trying to conceive, and ask a doctor before use.
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community Is Retinol effective by itself?

4 upvotes 1 year ago

Retinol is not effective alone for hair loss; tretinoin is more potent and sometimes mixed with minoxidil. Retinoids do not stop hair loss, and finasteride or dutasteride is necessary for that.

community Retinol substitute for Tretinoin

4 upvotes 2 years ago

The user is seeking a substitute for Tretinoin to enhance the effectiveness of Minoxidil for hair loss. They are considering using Retinol as an alternative.

community Can retinol add hair regrowth when combined with micro needling/topical minoxidil

2 upvotes 1 month ago

The conversation discusses a hair loss treatment regimen including finasteride, minoxidil, micro needling, and oil blends. It questions the addition of retinol, with feedback suggesting tretinoin is more effective, while retinol may cause hair loss.

community What is your experience adding retinol to minoxidil?

4 upvotes 1 year ago

Adding retinol to a hair loss routine, with a user suggesting starting with a lower dose. Another user mentions using tretinoin with minoxidil for potential benefits.

community the ordinary retinol & minoxidil

in Minoxidil 13 upvotes 1 year ago

Using retinol with minoxidil may not be as effective as tretinoin, but retinaldehyde or adapalene could be alternatives. A micro-roller with minoxidil is suggested for better results.

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