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research Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression (Catagen) by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

92 citations , June 2005 in “Journal of Investigative Dermatology”

This study found that the retinoid all-trans retinoic acid induced a catagen-like stage in human scalp hair follicles, suggesting upregulation of TGF-beta2 as a contributing mechanism.

research Retinoic Acid-Induced Epidermal Transdifferentiation in Skin

1 citations , June 2014 in “Journal of developmental biology”

This study found that retinoic acid induces epidermal transdifferentiation into mucosal epithelium in both chick and mammalian embryonic skin, involving specific gene expressions and pathways.

research Retinoic Acid Is Not Involved in Fluconazole-Induced Alopecia: Evaluation in a Human Cohort and Rat Model

1 citations , January 2016 in “Open Forum Infectious Diseases”

This study found that fluconazole induced early hair follicle resting phase (telogen effluvium) in rats, without changing retinoic acid levels in rats or human patients, suggesting further investigation into fluconazole's hair loss mechanism is needed.

research Generalized hair loss induced by indinavir plus ritonavir therapy

17 citations , August 2002 in “AIDS”

This study observed that patients undergoing indinavir/ritonavir therapy for HIV-1 frequently experienced reversible alopecia, likely due to retinoid-like effects, but these were independent of other retinoid-like skin manifestations.

research Drugs and Hair Loss

54 citations , September 2012 in “Dermatologic Clinics”

This review discusses possible medication-induced hair loss and the need to exclude other confounding factors like stress and illness; it reports no new clinical findings and emphasizes careful assessment before attributing hair loss to medications.

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community Tretinoin for some men(not all) can cause non-telogen effluvium hair loss

in Research/Science 5 upvotes 1 year ago

Tretinoin can cause non-telogen hair loss in some men by inducing catagen-like changes in hair follicles and through retinoid toxicity, especially when used with minoxidil. Some users report hair loss even when using retinoids on the face, while others experience benefits when combined with treatments like finasteride and minoxidil.

community Tazarotene is extremely underrated in relation to hair regrowth

12 upvotes 6 months ago

A user discusses using tazarotene to enhance minoxidil's effectiveness for hair regrowth, believing it will make a significant difference. Others caution about potential risks of retinoids accelerating hair loss in some individuals.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 2 years ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community The Ultimate Guide to growing your hair back (revised).

in Treatment 161 upvotes 1 year ago

Hair loss treatments include using finasteride, dutasteride, and RU58841. Lifestyle changes like increasing carb intake and moderate alcohol consumption are suggested to boost estrogen levels.

community Shedding kind of looks like balding

in Progress Pictures 11 upvotes 1 month ago

The conversation discusses hair loss treatments, primarily finasteride, and the effects of shedding, miniaturization, and regrowth. Users share experiences with finasteride, minoxidil, and dutasteride, noting normal shedding patterns and potential regrowth signs like baby hairs.

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learn retinol

How often should retinol scalp treatments be used to see improvement without over-exfoliating? No study has worked out a safe or effective frequency for retinol on the scalp, and lab studies show retinoic acid can push hair follicles into early regression (catagen). Ask a dermatologist, and avoid retinoids in pregnancy.
Does retinol improve scalp health or help other hair growth treatments work? No trial has tested over-the-counter retinol for hair; the studies used prescription tretinoin (retinoic acid), mostly in the lab, with mixed results. Retinoids need caution in pregnancy, so ask a doctor first.
Is retinol safe to use on the scalp, or should it be diluted to avoid irritation? There is little research on retinol on the scalp; retinoids often cause redness, dryness and peeling, and long-term scalp safety has not been studied. Avoid retinoids if pregnant or trying to conceive, and ask a doctor before use.

learn Tretinoin

Vitamin A retinoid cream, prescribed for acne

learn RU58841

Will I lose my hair if I stop using RU58841? (Spoiler: I might.) There is no published human trial of stopping RU58841; community members commonly report shedding within weeks to months, and androgen biology suggests miniaturization would resume once the topical anti-androgen is withdrawn.

learn vitamin A

Can too much vitamin A cause hair loss? Sustained vitamin A intake above the tolerable upper limit (3,000 mcg/day of retinol for adults) is linked in case reports to diffuse hair shedding; the claim that it amplifies DHT-driven hair loss has no published human evidence behind it.

learn Retinyl Palmitate

learn Redensyl

Cosmetic ingredient blend sold for thinning hair

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