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learn retinol

Is retinol safe to use on the scalp, or should it be diluted to avoid irritation? Retinol can be used on the scalp but should be diluted to minimize irritation.
How often should retinol scalp treatments be used to see improvement without over-exfoliating? Use retinol scalp treatments 1-2 times a week to avoid over-exfoliation.
Can retinol help enhance the absorption of ingredients like minoxidil or peptides? Retinol may enhance absorption of minoxidil and peptides by modifying skin barrier properties.

learn retinoic acid

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Research

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research Clinical Toxicityof Retinoids

July 2020

This article discusses variations in retinoid pharmacokinetics affecting their toxicity and clinical efficacy, but reports no new results; the authors emphasize considering toxicity in selecting suitable compounds.

research A COMPARISON OF THE TOXICITIES OF 4-(ETHOXYCARBOPHENYL) RETINAMIDE AND SOME OTHER RETINOIDS

January 1982

This study found that 4-(ethoxycarbophenyl) retinamide (RI) exhibited significantly lower acute, subacute, and chronic toxicity compared to other retinoids in mouse and rat models.

research Preliminary toxicity profile of arotinoids SMR-2 and SMR-6 in male B6D2F1 mice*1

15 citations , May 1987 in “Fundamental and applied toxicology”

This study found that SMR-2 and SMR-6, analogs of retinoic acid and retinol, were approximately 100 times more toxic than retinoic acid in mice, inducing hypervitaminosis A and affecting various organs and tissues.

research DGAT1 Modulates Hair Cycling and Is Essential for Retinoid Homeostasis in the Skin

June 2007

This study found that the enzyme encoded by Dgat1 acts as a retinol acyltransferase in murine epidermis, protecting against retinoid toxicity and alopecia by preventing retinol accumulation.

research Oral Retinoids in Dermatology

52 citations , June 1981 in “International Journal of Dermatology”

Oral retinoids are effective for severe skin conditions but require careful use due to side effects.

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Community Join

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community Tretinoin for some men(not all) can cause non-telogen effluvium hair loss

in Research/Science 5 upvotes 1 year ago

Tretinoin can cause non-telogen hair loss in some men by inducing catagen-like changes in hair follicles and through retinoid toxicity, especially when used with minoxidil. Some users report hair loss even when using retinoids on the face, while others experience benefits when combined with treatments like finasteride and minoxidil.

community 2 years of 5% topical minoxidil + 1 year of 1mg finasteride.

in Progress Pictures 236 upvotes 5 months ago

The user shared progress pictures after using 5% topical minoxidil for two years and 1mg finasteride for one year, but many commenters believe the hair looks the same, attributing changes to different haircuts rather than actual regrowth. The user reported no side effects from finasteride, and opinions varied on whether any significant hairline improvement occurred.

community Minoxidil works only with Retinoic acid

314 upvotes 1 year ago

Minoxidil is more effective when combined with retinoic acid, such as tretinoin or tazarotene, enhancing hair growth. Some users experience significant regrowth, while others see minimal effects or side effects.

community New Preprint: Retinoic Acid Supports Verteporfin-Induced Regeneration

17 upvotes 2 months ago

Verteporfin followed by retinoic acid improves wound regeneration in mini-pigs. Retinoic acid does not significantly enhance regeneration in rabbits.

community Oral minoxidil vs Topical Minoxidil w/ Retinoic acid

6 upvotes 1 year ago

Topical minoxidil with retinoic acid is effective but causes scalp irritation, leading the user to consider switching to 2.5mg oral minoxidil. Oral minoxidil may cause body hair growth and heart-related side effects, so it's advised to use it under medical guidance.

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