114 citations
,
October 2009 in “Gastroenterology” This review discusses zinc's role as an essential trace element in human nutrition, particularly its importance in total parenteral nutrition, and reports no new clinical results.
February 1990 in “Pathology, research and practice” This study in rats with a portocaval shunt observed severe ultrastructural damage to the inner ear, associated with zinc deficiency and symptoms resembling liver cirrhosis in humans.
50 citations
,
May 1985 in “The journal of pediatrics/The Journal of pediatrics” This study reported successful treatment of biotin deficiency in three patients receiving total parenteral nutrition, suggesting current biotin supplementation recommendations may be inadequate to maintain normal biotin status.
3 citations
,
December 2019 in “Biomaterials Research/Biomaterials research” This study found that the concentrations of major inorganic elements in human scalp hair increase with age up to 25 years, and calcium and magnesium concentrations are significantly associated with sex in individuals over 20.
43 citations
,
April 2005 in “The Journal of Dermatology” This case report describes a 5-month-old Japanese infant with biotin deficiency, where daily oral biotin supplementation led to significant improvements in skin conditions and hair growth.
10 citations
,
January 2016 in “Global Dermatology” This study observed that zinc deficiency in humans and mice was associated with diminished allergic contact dermatitis but increased severity and duration of irritant contact dermatitis.
3 citations
,
February 2005 in “Journal of Quantitative Spectroscopy & Radiative Transfer/Journal of quantitative spectroscopy & radiative transfer” This study found that hair content of iron and zinc does not play a role in chemotherapy-induced alopecia in children with cancer.
35 citations
,
January 2006 in “Journal of Dermatological Treatment” This review found little evidence supporting zinc as a first-line treatment for dermatological conditions, except in cases of systemic zinc deficiency, and suggests further research is needed.
43 citations
,
October 2002 in “International Journal of Cosmetic Science” This study found that 1% ketoconazole and 1% piroctone olamine shampoos increased hair shaft thickness and reduced hair shedding in men with telogen effluvium and androgenic alopecia associated with dandruff.
75 citations
,
May 2013 in “Journal of the American Academy of Dermatology” This review examines skin symptoms, diagnosis, and treatment of zinc deficiency in children, proposing a classification system but reporting no new clinical results.
5 citations
,
April 2013 in “Nasza Dermatologia Online” This study reports no new clinical results on oral zinc therapy for acrodermatitis enteropathica but provides demographic data and symptom prevalence among thirty affected children.
December 2023 in “Journal of nutritional science and vitaminology” This study in mice found that a zinc-deficient diet suppressed body weight gain and increased kidney and cecum tissue weight without decreasing serum alkaline phosphatase activity. Additionally, zinc deficiency caused alopecia and intestinal changes in C57BL/6J mice, potentially affecting nutritional status.
June 2022 in “International Journal of Health Sciences (IJHS) (En línea)” This study found that pregnant women in Al Muthanna Province, Iraq, frequently have low serum zinc and ferritin levels, especially those experiencing hair loss, posing a significant public health concern.
April 2018 in “Assiut Veterinary Medical Journal/Maǧallaẗ Asyūṭ al-ṭibiyyaẗ al-baytariyyaẗ” This study found that fecal zinc concentration can serve as a biomarker for early diagnosis of zinc deficiency in lambs, complementing serum zinc evaluations.
21 citations
,
June 2011 in “Journal of child neurology” This study found that while serum zinc levels were lower in children treated with valproic acid or carbamazepine than in healthy controls, zinc, biotin, and biotinidase enzyme activity remained within normal ranges and unaffected by these treatments.
19 citations
,
February 2018 in “Nutrients” This review discusses the relationship between zinc deficiency and skin disorders, emphasizing zinc transporters' roles, but it reports no new clinical results; the authors highlight potential benefits of regulating zinc levels via transporters.
12 citations
,
July 1979 in “International Journal of Dermatology” This article reviews the clinical manifestations and contributing factors of acute zinc depletion syndrome, reporting no new results but discussing prevention and treatment strategies.
11 citations
,
February 2019 in “Journal of Cosmetic Dermatology” This study found that male androgenetic alopecia patients had significantly lower serum zinc levels and suboptimal biotin levels compared to healthy controls, suggesting the potential value of zinc and biotin supplementation.
4 citations
,
January 2013 in “PubMed” In this study, testosterone and finasteride were found to increase insulin and zinc levels while decreasing chromium levels in male adult rats, suggesting potential effects on the glucose cycle.
3 citations
,
January 1985 in “British Journal of Dermatology” In this study, a low concentration zinc sulphate solution was investigated for managing recurrent herpes simplex infections, but no new clinical results were reported.
January 2024 in “Biological trace element research” In this study, isotretinoin treatment for acne vulgaris was associated with changes in plasma phosphorus, potassium, magnesium, and zinc levels, potentially affecting kidney function and contributing to side effects like fatigue and dry skin.
February 2021 in “Austin journal of nutrition & metabolism” This study found that among university students, both low and high zinc levels were associated with significant hair loss, while these zinc concentrations did not significantly impact other health issues like diarrhea, acne, or weight loss.
January 2021 in “Middle East journal of applied sciences” This article discusses the widespread issue of zinc deficiency affecting plant, animal, and human health, and reports no new clinical results; the authors emphasize the need for adequate zinc availability in agriculture and nutrition.
27 citations
,
May 2010 in “Dermatologic Clinics” This review discusses the use of zinc in treating dermatological conditions and concludes that, aside from systemic zinc deficiency, its efficacy as a primary treatment is unproven, though it may be useful as a supplementary therapy.
158 citations
,
May 1968 in “The journal of nutrition/The Journal of nutrition” This study found that severe zinc deficiency induced in weanling rats led to growth retardation, hair issues, and dermal lesions, all of which were completely reversed by zinc supplementation.
60 citations
,
October 2005 in “Experimental Dermatology” This study found that high-dose oral zinc significantly influences hair growth in mice, showing both inhibition and promotion effects depending on the timing and duration of administration.
5 citations
,
December 2014 in “Polish Journal of Public Health” This review discusses the mechanisms of zinc transport, its role in human health, and the effects of zinc imbalance, without reporting new results.
April 2026 in “Al-Kufa University Journal for Biology” This pilot study observed that post-bariatric surgery, both zinc and iron deficiencies increased among Iraqi patients, underscoring the importance of lifelong nutritional monitoring and targeted supplementation to address these issues and prevent related complications.
324 citations
,
July 2020 in “Applied Water Science” This study found high levels of toxic heavy metals in water sources of mining communities in Abakaliki, Nigeria, posing potential health risks including Parkinson's and Alzheimer's diseases.
20 citations
,
December 2011 in “Journal of inherited metabolic disease” This study found that valproic acid may interfere with the leucine metabolic pathway by inhibiting 3-methylcrotonyl-CoA carboxylase and biotinidase, which could contribute to side effects like skin rash and hair loss in patients.