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This study using zebrafish observed that inherited coping styles had a stronger impact on responses to social defeat stress than social rank, with subordinate fish showing more vulnerability to health impairments, including gut inflammation and skin injuries.

In this study, the researchers observed that post-radiation hair follicle repair in 3D architecture occurs through independent, long-range cell movements along the basal surface, resembling 2D healing processes.

This study on feather pattern formation in chicken skin found that inhibiting gap junctional intercellular communication can lead to the emergence of new feather buds in specific spatial patterns, suggesting that GJIC may facilitate Turing-type periodic patterning by propagating inhibitory signals over long distances.

Innovative methods are reducing animal testing and improving biomedical research.

This study found that feather patterning is primarily self-organizing and dynamic, relying on both genetic and epigenetic controls, with implications for similar processes like fingerprints and pigmentation.

In this study using genetic mouse models, researchers discovered that senescent melanocytes in nevi secrete osteopontin, which activates hair stem cells, enhancing hair growth; this process is mirrored in human hairy nevi, suggesting a potential therapeutic target for regenerative disorders.

This study reports that dynamic interactions between stem cells and their niche, influenced by macro-environmental factors, regulate regenerative behavior in integument pattern formation.

This commentary highlights the potential of using transgenic and genome-edited mouse models to validate findings from livestock genomic and multi-omic analyses, aiding in the understanding of economically significant animal traits.

This study constructed a comprehensive atlas of prenatal human skin, revealing that innate immune cells, such as macrophages, play a crucial role in skin morphogenesis by interacting with non-immune cells, influencing hair follicle formation and angiogenesis beyond their traditional immune functions.

This study found that zebrafish can completely regenerate their ventricular myocardium within four weeks, with Wnt/β-catenin signaling playing a critical role in cardiomyocyte dedifferentiation and proliferation.

This article reviews the generation of complex integument patterns through genetic, chemical, and environmental influences, with applications in tissue engineering, but reports no new experimental results.

This study found that inherited coping styles influenced zebrafish responses to social stress more than social rank, with subordinate fish more vulnerable to health impairments like inflammation and skin injuries.

This study developed the mTurquoise2-Col4a1 mouse model and used fluorescent tagging of collagen IV to offer new insights into basement membrane dynamics during hair follicle budding, revealing that basement membranes are flexible and stable structures in developing skin tissue.

In this study, researchers identified that the oncomodulin protein lineage, specifically the gene pvalb8, plays a crucial role in the development and function of auditory hair cells in zebrafish by promoting cell proliferation through the Wnt signaling pathway.

This article discusses the potential for combining PROTACs with other therapeutic modalities in drug discovery and reports no clinical results.

In this study, researchers found that during zebrafish telencephalon regeneration, the lesioned hemisphere showed distinct gene expression changes and activated Wnt/β-catenin signaling early after injury, suggesting this pathway's significant role in recovery.

LSD1 is crucial for regenerating hair cells in zebrafish.

This review highlights the diverse roles of melanocytes in pigmentation, immunity, and hearing among other functions, their involvement in disorders, and their emerging potential in regenerative medicine, including applications in disease modeling and therapy development using advanced technologies.

This review discusses recent research on melanocyte stem cells and explores the differences between mouse and human skin, but it reports no new clinical results.

This study found that mice with a homozygous knockout of the Ten1 gene, developed through CRISPR-Cas9-mediated exon 3 deletion, exhibited telomere shortening and symptoms consistent with accelerated aging, such as reduced lifespan, skin changes, aplastic anemia, and cerebellar hypoplasia.

Hyaluronic acid microneedles help deliver minoxidil derivatives effectively for hair regrowth.

This study found that the clionasterol-rich hexane fraction of Caulerpa racemosa may protect against particulate matter-induced skin damage by reducing oxidative stress and mitochondrial-mediated apoptosis in human keratinocytes and zebrafish.

This review highlights the potential of permeation enhancers to improve the delivery of active ingredients across the skin, optimizing therapeutic outcomes despite challenges posed by individual variability and environmental factors, according to the authors' analysis of current understanding and applications in skincare and transdermal therapies.

This review discusses the state-of-the-art knowledge on pseudoxanthoma elasticum, summarizing recent advancements in genetics, pathomechanisms, and potential treatments but reports no new clinical findings.

This study demonstrated how cellular flows and tissue mechanics guide the topological transformations in avian skin, essential for feather follicle development from scales.

This study found that zebrafish and stickleback fish use similar genetic programs for tooth regeneration, despite differences in their dental structures.

This review discusses genetically-engineered mouse models for studying melanocytes and reports no new experimental findings; it emphasizes their potential to address unanswered questions in melanoma biology.

This review discusses mammalian models of epimorphic regeneration to define a vertebrate regeneration blastema, concluding that regenerative failure likely stems from cellular responses to the microenvironment after injury, not progenitor cell availability, and calls for targeted modification studies in mammals to advance human regeneration.

This chapter reviews classic regeneration models in planarian worms and amphibian limbs, focusing on the role of stem cells, and reports no new experimental results.

This review discusses insights from scar-free animal models and cellular factors in skin regeneration, suggesting potential strategies for developing scar-free treatments in clinical and cosmetic practices, but reports no new clinical results.