84 citations
,
October 2007 in “The Journal of Immunology” This study found that chronic eczema supports the expansion of myeloid suppressor cells, which contribute to silencing autoreactive T cells and partially promote hair regrowth in alopecia areata.
38 citations
,
January 2016 in “Cell Death and Disease” This review discusses the role of the TCL1 transgenic mouse model in understanding chronic lymphocytic leukemia biology and highlights the importance of exploring new pathogenetic and therapeutic targets.
139 citations
,
February 2010 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” This review outlines the advancements in organ and tissue transplantation since the discovery of the human MHC and reports no new clinical results.
130 citations
,
November 2017 in “Frontiers in Immunology” This review explores recent findings on regulatory T cells, focusing on their unique functions in non-lymphoid tissues and new mechanisms of action, but presents no original clinical results.
48 citations
,
January 2024 in “Immune Network” This review highlights recent insights into how IL-15 influences T cell responses and contributes to immunopathogenesis in various diseases, suggesting its crucial role in TCR-independent activation and potential in optimizing therapeutic strategies.
36 citations
,
January 2021 in “Scientific Reports” This study identified key genes and signaling pathways involved in the growth phases of Pashmina goat hair follicles, highlighting the role of several gene families and transcription factors in fiber quality and growth regulation.
20 citations
,
June 2010 in “Genes and Immunity” This study found distinct gene expression patterns in the blood of alopecia areata patients, suggesting involvement of immune processes and new pathways like Wnt signaling and apoptosis in disease pathogenesis.
13 citations
,
August 2020 in “Frontiers in Immunology” This review explores the expression of Perforin by gamma delta T cells in human skin and its role in cytotoxicity but reports no new experimental results.
4 citations
,
November 2023 in “Frontiers in immunology” In this narrative review, researchers outlined the role of T cells in the autoimmune pathogenesis of alopecia areata and highlighted ongoing research into therapeutic pathways, beyond current JAK inhibitors, aimed at developing new treatments for the disease.
1 citations
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April 2025 in “Tropical Journal of Natural Product Research” In this study, researchers using network pharmacology and molecular docking methods found that compounds from Avicennia Marina could inhibit hepatitis C virus infection by targeting key proteins such as AKT1 and TNF-α, showing potential for anti-HCV treatments.
1 citations
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January 2021 In this study, CD4+ non-haematopoietic, skin-resident stem cell-like populations were identified in both murine and human epidermis, suggesting they may serve as potential basal cell carcinoma precursors.
January 2023 in “Åbo Akademi University Research Portal” This study found that vimentin is essential for proper wound healing and cell growth by influencing EMT signaling and mTOR activity in mice.
October 2021 in “Research Square (Research Square)” This study found that gene expression patterns can effectively distinguish the cashmere growth cycle stages and highlight molecular pathways, suggesting melatonin's role in regulating cashmere growth in Inner Mongolian goats.
June 2021 in “Research Square (Research Square)” This study reports that melatonin influences gene expression related to cashmere growth cycles in Inner Mongolian cashmere goats, potentially aiding in understanding and enhancing cashmere yield through molecular regulation.
March 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that type 2 immunity, especially involving ILC2 cells, helps maintain skin homeostasis by regulating the proliferation and community stability of hair follicle epithelial cells in the presence of Demodex mites.
February 2010 in “ePrints Soton (University of Southampton)” This research found that androgen bioactivity plays a role in normal female sexual differentiation, suggesting females develop within a significant androgenic environment, with implications for understanding conditions like congenital adrenal hyperplasia.
57 citations
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March 2011 in “Pediatric Dermatology” In this study, skin manifestations were observed in 48% of children with primary immunodeficiency disorders, often providing crucial diagnostic clues for early identification of these conditions.
9 citations
,
May 2023 in “Inflammation Research” This study reported that new drugs, despite lower specificity compared to certain immunobiological therapies, are effective across various challenging dermatological diseases, such as psoriasis, psoriatic arthritis, atopic dermatitis, alopecia areata, and vitiligo.
1 citations
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March 2024 in “Signal transduction and targeted therapy” In this review, researchers explored the multifaceted role of NF-κB signaling in various biological processes and diseases, including its interactions with other pathways, and discussed possible therapeutic approaches targeting this pathway for treating conditions like cancer, autoimmune disorders, and COVID-19.
1 citations
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February 2015 in “Clinical and Experimental Dermatology” This case report details a patient who developed multiple skin cancers within one year of receiving an allogeneic haematopoietic cell transplant for chronic lymphocytic leukaemia.
51 citations
,
December 2006 in “Mammalian Genome” This study found that inhibiting mTORC2 in glioblastoma cells reduced DNA repair and increased apoptosis, highlighting its potential role in cancer cell survival and DNA damage response.
52 citations
,
June 1991 in “Journal of Virology” In this study, researchers found that the ability of hamster polyomavirus to cause lymphoid tumors in Syrian hamsters may be linked to its association with the tyrosine kinase p59fyn.
October 2014 in “Cancer research” This study found that targeting mTORC1 with rapamycin effectively inhibited skin tumor promotion in a mouse model, highlighting a potential target for cancer chemoprevention.
March 2026 in “Animal Models and Experimental Medicine” In a dermal Gorab knockout mouse model, this study found that Gorab mutations increase P53 protein accumulation and disrupt extracellular matrix expression, contributing to accelerated skin aging and suggesting a pathway involving epigenetic regulation.
April 2012 in “Cancer research” In this study, the authors found that targeting mTORC1 with rapamycin inhibited TPA-induced skin tumor promotion by affecting keratinocyte proliferation, including critical stem cell populations in the mouse epidermis.
February 2020 in “Definitions” This article discusses the human KRT72 wild-type allele's role in hair formation and reports no new research findings.
January 2018 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that the mutant hairless rhino bald protein in mice interacts with the vitamin D receptor but cannot repress its transactivation and shows abnormal cellular localization.
8 citations
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September 2013 in “Molecular carcinogenesis” This study found that rapamycin effectively inhibits TPA-induced keratinocyte proliferation and skin tumor promotion by targeting mTORC1 signaling in both wild-type and transgenic mice.
324 citations
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May 2002 in “Oncogene”