1 citations
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November 2005 in “Dermatologic Surgery” This study found that aminoguanidine induces VEGF mRNA expression in stored hair follicle micrografts and outer root sheath cells, suggesting potential for enhancing growth factor production during storage.
June 2025 in “Animal Bioscience” This study found that miRNA-24 downregulates the KLF6 gene, influencing coat color by affecting melanogenesis pathways in Cashmere goats, and that miRNA-24 inhibition increased melanin content in mice.
September 2021 in “Research Square (Research Square)” This study reports that despite rescuing neurulation and skin barrier defects, Grhl3 gene overexpression in mice leads to hearing impairment, hair loss, and other developmental abnormalities, highlighting low tolerance for Grhl3 dysregulation.
June 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that the HoxC gene cluster is crucial for the development of hair and nails in mice, with key regulation by two mammalian-specific enhancers.
58 citations
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January 2013 in “The Journal of Clinical Endocrinology and Metabolism” This study suggests that sexual dimorphism in adipose tissue functions may be linked to androgen levels, as women with PCOS demonstrated a more masculine adipokine expression pattern.
26 citations
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May 2012 in “Cellular and Molecular Life Sciences” This review discusses the structure, expression, regulation, and potential roles of NcoA4 in cancer and other pathologies, reporting no new experimental findings.
25 citations
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January 2017 in “Steroids” This study found that the progesterone metabolite 3α-THP increased the proliferation and gene expression of human glioblastoma cells, suggesting a role in tumor progression.
25 citations
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June 2014 in “Journal of Endocrinology/Journal of endocrinology” This study found that local androgen biosynthesis and metabolism in human sebaceous glands play a crucial role in sebum synthesis and secretion.
24 citations
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March 2017 in “Archives of Gynecology and Obstetrics” The study found that women with hyperandrogenic PCOS have higher levels of AKT1 and AKT2 proteins in their cells, which may lead to cell dysfunction.
This study found that Wnt7a protein expression increased after corneal epithelial injury and promoted human corneal epithelium cell proliferation by upregulating fibronectin and enhancing cell adhesion.
37 citations
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March 2010 in “British Journal of Dermatology” Oestrogen and thyrotropin-releasing hormone affect prolactin and its receptor in human skin and hair, suggesting new treatment options for related conditions.
25 citations
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September 1998 in “The Journal of Steroid Biochemistry and Molecular Biology” This study concludes that rhesus macaques are a suitable model for testing the pharmacological properties of finasteride and other 5aR inhibitors, due to their biochemical similarity to humans.
22 citations
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October 2020 in “Frontiers in Cell and Developmental Biology” This study found that resveratrol and fisetin promoted hair growth in mice by inducing telomerase reverse transcriptase expression, which activates hair follicle stem cells and transitions follicles from a resting to a growth phase.
17 citations
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June 2019 in “The journal of immunology/The Journal of immunology” This study identified a regulatory element necessary for Foxn1 expression specifically in mouse thymic epithelial cells, crucial for thymus development but not affecting hair follicles.
13 citations
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July 2016 in “BMC Complementary and Alternative Medicine” In this study, topical application of Hominis Placenta significantly promoted hair regrowth and increased hair density in C57BL/6 mice, suggesting its potential as a treatment for alopecia.
5 citations
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May 2020 in “Life science alliance” This study found that epidermal-specific deletion of integrin α3β1 significantly reduces papilloma formation in a skin carcinogenesis model by modulating HB stem cell behavior and CCN2 expression.
August 2024 in “Qucosa (Saxon State and University Library Dresden)” In this study on mice, researchers observed that dermal white adipose tissue (dWAT) plays a key role in regulating skin inflammation and tissue repair; however, reduced expression of certain cytokines in obese mice may hinder these processes, indicating potential metabolic disruptions in dWAT during inflammation.
January 2024 in “Wiadomości Lekarskie” In this study, researchers analyzed spermogram data from men with diagnosed infertility in Ukraine, aiming to identify the most common sperm disorders, and they found that the study primarily involved men with primary infertility, compared to a control group of healthy men with confirmed fertility.
13 citations
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July 2018 in “General and comparative endocrinology” This study observed that direct exposure to androgens in Western clawed frogs differentially affects thyroid receptor and deiodinase gene expression in male and female tissues, offering insight into sex-specific metabolic pathway activation.
12 citations
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August 2018 in “Journal of Dermatological Science” This study observed that adipose-derived stem cells modified with trichogenic factors have similar properties to dermal papilla cells and show enhanced hair regeneration potential compared to unmodified adipose-derived stem cells.
11 citations
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January 2015 in “Skin pharmacology and physiology” In this study, oral collagen peptides increased certain gene expressions related to epidermis development and the hair cycle in hairless mice skin, suggesting potential links to hair health.
10 citations
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January 2018 in “Organogenesis” This study found that epidermal stem cell-specific Jag1 expression levels are crucial for effective wound healing and scar reduction, and porcine acellular dermal matrix treatment enhances this process in mice by boosting Notch/Jagged1 signaling.
7 citations
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July 2018 in “Journal of Investigative Dermatology” This article reviews the genetic research on male androgenetic alopecia, highlighting that over 300 associated risk variants have been identified, with unclear mechanisms of action.
7 citations
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April 2018 in “Molecular Medicine Reports” This study found that BeauTop, a supplement containing several traditional Chinese herbs, may promote hair growth in mice with alopecia, potentially by modulating EGF and FGF-7 levels.
3 citations
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August 2018 in “Deleted Journal” This study found that Guasha therapy did not significantly alter nerve fiber morphology or the expression of CGRP and SP in rat skin, with parameters generally returning to normal within five days.
March 2011 in “European Urology Supplements” Gene variation affects prostate issues and hair loss.
52 citations
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October 1999 in “Developmental Dynamics” This study found that the hairless gene in mice has a more extensive role in development than previously thought, as indicated by its expression in various tissues and associated abnormalities in hr/hr mutants.
40 citations
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June 2011 in “Journal of biological chemistry/The Journal of biological chemistry” This study revealed that deficiency in the enzyme FA2H in mice affected sebaceous gland function, altered sebum composition, and caused cycling alopecia, highlighting FA2H's role in hair follicle homeostasis.
34 citations
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October 2021 in “Scientific Reports” This study found that nobiletin-loaded vesicles effectively restored skin condition in a mouse model of skin cancer, suggesting they are a promising treatment delivery system.
15 citations
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May 2017 in “Lasers in Medical Science” This study found that low-level laser treatment may promote hair regrowth in mice by activating the Wnt10b/ß-catenin pathway and inducing the anagen phase of hair follicles.