41 citations
,
March 2017 in “PLoS neglected tropical diseases” This study found that isotretinoin, a drug commonly used for acne, inhibits polyamine transport in Trypanosoma cruzi, leading to trypanocidal effects, and suggests its potential as a treatment for Chagas disease without affecting mammalian cell viability.
40 citations
,
January 2009 in “Skin Pharmacology and Physiology” This review discusses the potential use of cultured primary fetal cells from a single organ donation to produce therapeutic products, emphasizing the need for process consistency and safety verification, but reports no clinical results.
39 citations
,
January 2019 in “Journal of Dermatological Treatment” This review found topical ketoconazole to be highly effective against Malassezia-related skin conditions, though other treatments may outperform it for Tinea and Candida infections.
39 citations
,
June 2017 in “Journal of Applied Research on Medicinal and Aromatic Plants” This review examines around 68 plant sources from six major plant families, assessing their scientific rationale and use by the cosmeceutical industry for applications like anti-ageing and sun protection.
39 citations
,
January 2011 in “Archives of Dermatology” This study found that the yellow dot pattern observed in dermoscopy of alopecia areata corresponds to inefficient follicular structures containing hair remnants, as corroborated by reflectance confocal microscopy and pathological findings.
38 citations
,
September 2014 in “Cell and Tissue Research” This review explores the infundibulum's role and importance in skin diseases and emphasizes the need for further research into its biology and potential therapeutic targeting, but it presents no new findings.
38 citations
,
July 2010 in “Clinical, cosmetic and investigational dermatology” This review discusses systemic antifungal treatments for tinea capitis in children, noting that newer agents like terbinafine and itraconazole require shorter courses than the traditional griseofulvin, but may be more costly.
34 citations
,
February 2012 in “Journal of Cutaneous Pathology” This research retrospectively evaluated 92 skin specimens to propose histopathological criteria for diagnosing alopecia areata incognito, distinguishing it from telogen effluvium and androgenetic alopecia.
32 citations
,
November 2011 in “International Journal of Dermatology” This article reviews central centrifugal cicatricial alopecia, focusing on its multifactorial etiology and challenges in clinical diagnosis, and calls for more research and better treatment options.
29 citations
,
June 2005 in “Journal of Zoo and Wildlife Medicine” This study concluded that coat damage in captive rhesus macaques is unlikely caused by parasitic, bacterial, or mycotic infections but may be linked to environmental or behavioral factors affecting hair growth.
28 citations
,
January 2021 in “Parkinsonism & related disorders (Online)/Parkinsonism & related disorders” This article reviews skin disorders in Parkinson's disease, highlighting the potential of skin studies and stem cell research to advance understanding and treatment of the neurodegenerative disorder, without presenting new results.
28 citations
,
March 2017 in “African Journal of Traditional Complementary and Alternative Medicines” This study found that linseed oil, rich in flavonoids and terpenoids, significantly improved burn wound healing in terms of faster contraction, reduced inflammation, and enhanced tissue regeneration compared to other treatments, without adverse effects.
26 citations
,
May 2019 in “PLOS ONE” This study observed that hair follicles in hair loss patients had increased levels of Propionibacterium acnes, potentially linked to elevated immune response gene expression in miniaturized hair follicles.
24 citations
,
September 1996 in “Mycoses” This study found that androgenic steroids, particularly androstenedione and androstanedione, significantly reduced the growth of certain dermatophytes, suggesting hormonal influence on fungal infections in hair follicles.
23 citations
,
August 2012 in “Veterinary dermatology” This study found that feline superficial pyoderma was more prevalent in the dermatology-referral cats studied than previously reported, affecting mainly young cats with hypersensitivities and manifesting various lesion types.
22 citations
,
October 2020 in “Anais Brasileiros de Dermatologia” This consensus concluded that oral isotretinoin is highly effective for treating acne and some off-label conditions, with common adverse events being manageable and rare serious risks not contraindicating use.
21 citations
,
July 2014 in “Antimicrobial Agents and Chemotherapy” This study found that finasteride alone is highly effective in preventing Candida albicans urinary biofilms and shows synergistic activity with fluconazole in vitro, suggesting potential for further clinical investigation.
15 citations
,
March 2015 in “Australasian Journal of Dermatology” This study suggests that seborrhoeic folliculitis may represent a unique form of cicatricial alopecia, linking chronic scalp dermatitis-folliculitis with low-grade inflammatory fibrosing alopecia.
14 citations
,
April 2014 in “Medical Clinics of North America” This review discusses common skin conditions in primary care settings and provides guidance on differential diagnoses and selecting appropriate topical treatments, but it reports no new clinical results.
14 citations
,
March 2014 in “Journal of The American Academy of Dermatology” In this study, symmetrical acrokeratoderma was observed to frequently occur alongside ichthyosis vulgaris, with no specific therapy available for the condition.
13 citations
,
January 2024 in “Cureus” This study reviewed the physiological and psychological impacts of acne vulgaris, highlighting its complex interactions with endocrine issues, sebum production, and immune response, while suggesting that a multidisciplinary approach can inform future treatments and improve quality of life for those affected.
13 citations
,
February 2020 in “Cold Spring Harbor Perspectives in Biology” This review discusses the evolution of lineage-tracing strategies over the past century, emphasizing their role in identifying progenitor cells and resolving debates about cellular origins, with no new results reported.
12 citations
,
June 2012 in “Revista da Sociedade Brasileira de Medicina Tropical” This case study reported a rare infection by Trichosporon inkin, causing white piedra in a family in Southern Brazil, emphasizing the importance of molecular tools for precise identification.
12 citations
,
April 1995 in “Journal of Medicinal Chemistry” In this study, 4-substituted N-(1,1-dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides were synthesized and evaluated in vitro as potential 5 alpha-reductase inhibitors and antiandrogens.
11 citations
,
February 2021 in “Biomedicines” This review discusses the role of hair follicle bacterial colonization in immune responses and the pathogenesis of alopecia but reports no new clinical results.
9 citations
,
August 2024 in “Cureus” This study reviewed existing knowledge and research, observing that ketoconazole shampoo is a safe and effective treatment for scalp seborrheic dermatitis, significantly improving irritation and scaling while maintaining low relapse rates and minimal side effects.
9 citations
,
January 2019 in “Skin appendage disorders” This study found that among patients with seborrheic dermatitis, the "dandelion" vascular conglomerate observed through trichoscopy was correlated with Malassezia scalp colonization.
9 citations
,
January 2008 in “Medical mycology” In this study, ketoconazole treatment successfully cured a dog with erythematous epilation caused by Chaetomium globosum, with new hair growth observed 9 weeks later.
9 citations
,
July 1995 in “Veterinary Clinics of North America: Small Animal Practice” This review discusses causes of hair loss in cats, highlighting self-inflicted trauma due to flea allergy dermatitis, and presents no new clinical findings.
8 citations
,
November 2022 in “Cureus” In this study, patients with mild to moderate scalp seborrheic dermatitis experienced greater improvements in severity scores and quality of life with Lulican™ shampoo compared to Ketoconazole over four weeks, with similar safety profiles but better tolerability and cosmetic acceptability for LulicanTM.