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Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

Exposure to too much androgen before birth might cause polycystic ovary syndrome later in life.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Msx and Dlx genes are crucial for development, controlling cell behaviors like growth and differentiation through their roles as gene regulators.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Androgens can both increase and decrease hair growth in different parts of the body.

Certain cells from hair follicles can create new hair and contribute to hair growth when implanted in mice.

Early diagnosis and treatment, using finasteride, minoxidil, or hair transplantation, improves hair loss outcomes.

Use minoxidil for hair loss; finasteride and dutasteride for men, dutasteride for women.

WNT10A mutations often cause ectodermal dysplasias, with males showing more tooth issues than females.

The ZIP7 gene helps control zinc levels in cells by moving zinc from the Golgi apparatus to the cytoplasm.

Targeted cancer therapies often cause serious skin problems that need careful management.

Men are more likely to have severe COVID-19 cases and fatalities than women due to factors like lifestyle, aging, and biological differences.

Alopecia areata is an autoimmune condition causing hair loss due to the immune system attacking hair follicles, often influenced by genetics and stress.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Humans lost body hair relatively recently in evolution.

Guidelines for diagnosing common hair loss include detailed history, clinical examination, and various diagnostic techniques.

Alopecia areata causes hair loss, has no cure, and various treatments exist.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

Alopecia areata is a common autoimmune disease affecting about 2% of people, causing significant disability and often associated with mental health issues and other autoimmune conditions.

Too much androgen can cause hair loss; finasteride may help.

Some viruses can cause cancer by changing cell processes and avoiding the immune system; vaccines and targeted treatments help reduce these cancers.

Transplant success has improved with better immunosuppressive drugs and donor matching.

Different types of stem cells and their environments are key to skin repair and maintenance.

Modulating BMP activity changes the number, size, shape, and type of ectodermal organs.