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Estrogen Receptor ß (ERß) is the main hormone controller in human skin and hair follicles, not Estrogen Receptor α (ERα) or the Androgen Receptor (AR).

New treatments targeting specific genes show promise for treating keratin disorders.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Hair loss in men treated best with early medication or transplant, new treatments researched.

The document concludes that early diagnosis and treatment of Congenital Adrenal Hyperplasia are crucial for preventing serious health issues and improving patient outcomes.

Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.

TCDD speeds up skin barrier formation by increasing certain gene expressions.

Animal models have helped understand hair loss from alopecia areata and find new treatments.

COVID-19 can cause various skin lesions, which may result from the virus and immune response, and are not directly linked to illness severity.

Coats' Plus is a genetic disorder with eye abnormalities, brain calcification, poor growth, bone and skin issues, and movement disorders.

Wnt signaling is crucial for skin and hair development and its disruption can cause skin tumors.

Alopecia areata can cause unpredictable hair loss, and treatments like corticosteroids and minoxidil may help but have varying side effects.

Natural 5AR inhibitors effectively improve mild to moderate hair loss in men.

Different scaffold patterns improve wound healing and immune response in mouse skin, with aligned patterns being particularly effective.

Alisertib was found to be an effective and tolerable treatment for children with recurrent brain tumors.

Kennedy's disease leads to muscle weakness and sensory issues, has no cure but manageable symptoms, and future treatments look promising.

Plant extracts effectively reduce hair loss and increase growth, offering a safe alternative treatment.

The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.

DHT, a testosterone byproduct, causes male pattern baldness.

Prolactin may play a significant role in skin and hair health and could be a target for treating skin and hair disorders.

Despite progress in treatment, the exact cause of Alopecia areata is still unknown.

Understanding the genetics of rare inherited ichthyosis syndromes is key for better treatments and genetic counseling.

Hair diversity is influenced by complex genetics and environmental factors, requiring more research for practical solutions.

5α-reductase inhibitors, like finasteride and dutasteride, effectively treat BPH, male baldness, and hirsutism, with potential for acne and prostate cancer prevention.

The S100A4 protein is more common in psoriatic skin and could be a target for treating psoriasis.

Kids with alopecia areata may experience more stress but not necessarily feel more anxious or depressed than others.

Sex hormones may affect COVID-19 severity, with men often faring worse, and targeting related pathways could offer treatment options.

The gene KAP22-1 affects wool yield and fiber shape in sheep.

Kennedy's disease leads to muscle weakness without a cure, but exercise and managing symptoms may help patients live a normal lifespan.

Androgen is important in controlling stem cell differentiation, reducing fat development, and increasing lean mass.