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    Glossary Wrinkles

    lines or creases on the skin from aging and external factors

    Wrinkles, also known as rhytides, are lines or creases that form on the skin due to a combination of intrinsic aging processes and external factors such as sun exposure, smoking, and repetitive facial expressions. They occur as the skin loses its elasticity and collagen, leading to a thinner and less resilient dermal layer.

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    1. From skin microrelief to wrinkles. An area ripe for investigation Journal of Cosmetic Dermatology · 2003 · 108 citations
    2. Cloning of wrinkle-free, a previously uncharacterized mouse mutation, reveals crucial roles for fatty acid transport protein 4 in skin and hair development Proceedings of the National Academy of Sciences of the United States of America · 2003 · 93 citations
    3. The riddle of genuine skin microrelief and wrinkles International Journal of Cosmetic Science · 2006 · 52 citations
    4. Duration of wrinkle correction following repeat treatment with Juvéderm hyaluronic acid fillers Archives of Dermatological Research · 2010 · 48 citations
    5. Effects of Egg Shell Membrane Hydrolysates on UVB-radiation-induced Wrinkle Formation in SKH-1 Hairless Mice 2015 · 15 citations
    6. RETRACTED: The investigation and comparison of the efficacy and safety of stromal vascular fraction (SVF), platelet rich plasma (PRP), and 1064‐nm Q‐switched Nd:YAG laser in reducing nanofat treated infraorbital dark circles and wrinkles: A controlled blinded randomized clinical trial Skin Research and Technology · 2024 · 7 citations
    7. Hyperdiluting Calcium Hydroxylapatite With Platelet-Rich Plasma and Hyaluronidase for Improving Neck Laxity and Wrinkle Severity Cureus · 2024 · 4 citations
    8. Magnesium microneedle patches for under‐eye wrinkles Dermatologic Therapy · 2022 · 3 citations
    9. The Effectiveness of a Topical Rosehip Oil Treatment on Facial Skin Characteristics: A Pilot Study on Wrinkles, UV Spots Reduction, Erythema Mitigation, and Age-Related Signs Cosmetics · 2025 · 2 citations
    10. 810 Topical sulforaphane improves pigmentation and wrinkles associated with photoaging Journal of Investigative Dermatology · 2024
    11. A Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Effects of a Polyphenol-Rich Fruit Extract Combined with Biotin on Wrinkle Morphology, Skin Surface Roughness, and Hair Shedding Cosmetics · 2026
    12. Wrinkle reduction: what are the main treatment options available to patients? Journal of aesthetic nursing · 2017
    13. Perioral Wrinkles: Histologic Differences Between Men and Women Aesthetic Surgery Journal · 2009 · 80 citations
    14. Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function Cell death and disease · 2018 · 74 citations
    15. 3D Printed Hollow Microneedles for Treating Skin Wrinkles Using Different Anti-Wrinkle Agents: A Possible Futuristic Approach Cosmetics · 2023 · 17 citations
    16. Frontal Alopecia after Repeated Botulinum Toxin Type A Injections for Forehead Wrinkles: An Underestimated Entity? Skin appendage disorders · 2016 · 12 citations
    17. Synergistic effect of microneedle-delivered extracellular matrix compound and radiofrequency on rejuvenation of periorbital wrinkles Frontiers in Medicine · 2022 · 5 citations
    18. Anti-wrinkle effect of bone morphogenetic protein receptor 1a-extracellular domain (BMPR1a-ECD) BMB Reports · 2013 · 5 citations
    19. The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects Journal of Cosmetic and Laser Therapy · 2013 · 5 citations
    20. Enhancing Facial Skin Rejuvenation: A Clinical Evaluation of 4 MHz Monopolar Radiofrequency in Reducing Facial Wrinkles Dermatologic Therapy · 2025 · 1 citations
    21. Intradermal injection of platelet-rich plasma for periorbital wrinkles: A review Intisari Sains Medis · 2024
    22. Increased Preauricular Wrinkles in Frontal Fibrosing Alopecia Compared to Age-Matched Controls: A Prospective Study of 64 Patients Skin appendage disorders · 2019 · 3 citations
    23. Bald scalps and wrinkles Journal of The American Academy of Dermatology · 1989 · 1 citations
    24. The systemic wrinkled skin phenotype involves aberrant expression and variation of genes related to the oxidative stress and extracellular matrix in Xiang pigs BMC Genomics · 2025
    25. Management of forehead wrinkles Elsevier eBooks · 2020
    26. 182 Retinol remarkably effective in reducing neck wrinkles Journal of Investigative Dermatology · 2019
    27. 557 A peptide derivative with known anti-wrinkle properties was identified as potent dipeptiylpeptidase-4 inhibitor Journal of Investigative Dermatology · 2016
    28. A conditional multi-trait sequence GWAS discovers pleiotropic candidate genes and variants for sheep wool, skin wrinkle and breech cover traits Genetics selection evolution · 2021 · 11 citations
    29. Kudo Zero Sugar Collagen Anti-Aging Support Gummies Skincare & Beauty Reduces | Wrinkles & Fine Lines[WORK OR HOAX] Zenodo (CERN European Organization for Nuclear Research) · 2022
    30. A Clinical Trial Shows Improvement in Skin Collagen, Hydration, Elasticity, Wrinkles, Scalp, and Hair Condition following 12‐Week Oral Intake of a Supplement Containing Hydrolysed Collagen Dermatology Research and Practice · 2024 · 10 citations