4 citations,
November 2021 in “Frontiers in Cell and Developmental Biology” Aging causes hair loss and graying due to stem cell decline and changes in cell behavior and communication.
2 citations,
January 2022 in “Stem cell biology and regenerative medicine” The book "Hair Follicle Regeneration" discusses the potential of regenerating human hair follicles or activating dormant ones as a possible cure for baldness, and the promising role of new technologies like 3D printing in this field.
5 citations,
February 2022 in “International Journal of Molecular Sciences” Different immune cells like platelets, mast cells, neutrophils, macrophages, T cells, B cells, and innate lymphoid cells all play roles in skin wound healing, but more research is needed due to inconsistent results and the complex nature of the immune response.
December 2022 in “Nature Communications” The study introduces a bead-jet printing system for sparse mesenchymal stem cell (MSC) patterning, significantly enhancing skeletal muscle and hair follicle regeneration. Using Matrigel beads to encapsulate MSCs, the system improves cell retention, proliferation, and migration compared to traditional methods. High-density MSCs in sparse patterns among acellular beads provide superior therapeutic outcomes, reducing the number of MSCs needed for effective treatment. The method activates the PI3K-Akt and Wnt/β-CATENIN signaling pathways, leading to better muscle regeneration with less fibrosis and improved skin healing with increased hair follicle formation. The findings suggest that bead-jet printing of MSCs in high-density patterns can significantly enhance tissue regeneration outcomes, making it a promising approach for large-scale traumatic injury therapy.
79 citations,
January 2018 in “Wiley Interdisciplinary Reviews-Developmental Biology” Understanding how baby skin heals without scars could help develop treatments for adults to heal wounds without leaving scars.
1 citations,
December 2022 in “BMC Genomics” The Msx2 gene affects feather development in Hungarian white geese and a specific gene variation could indicate feather quality.
January 2021 in “Journal of cosmetology & trichology” Ageratum conyzoides L. extract may effectively and safely treat hair loss.
26 citations,
July 2016 in “Journal of biological chemistry/The Journal of biological chemistry” sPLA2-IIE is crucial for normal hair follicle structure and skin health.
September 2017 in “Journal of Investigative Dermatology Symposium Proceedings” Prostaglandin D2 increases testosterone production in skin cells through a process involving reactive oxygen species, which could be a new target for treating hair loss and other skin conditions driven by testosterone.
2 citations,
September 2023 in “International journal of molecular sciences” Special proteins are important for skin balance, healing, and aging, and affect skin stem cells.
October 2022 in “The Korean Journal of Physiology and Pharmacology” Prostaglandin D2 (PGD2) and its receptors play significant roles in hair growth regulation, particularly in androgenetic alopecia (AGA). Elevated levels of PGD2 in balding scalp regions suppress hair growth via the DP2 receptor. Studies have shown that PGD2 inhibits hair follicle regeneration and induces apoptosis in hair follicle cells. Cetirizine, an antihistamine that reduces PGD2 production, has shown promise in promoting hair regrowth in AGA patients. Other treatments like setipiprant, a DP2 antagonist, and levocetirizine hydrochloride, which down-regulates PGD2 and up-regulates growth pathways, also show potential. These findings suggest targeting the PGD2-DP2 pathway could be effective for AGA treatment.
23 citations,
December 2021 in “Frontiers in Immunology” IL-1 family cytokines are crucial for skin defense and healing, but their imbalance can cause skin diseases.
1 citations,
January 2024 in “Cellular & Molecular Biology Letters” Adipose-derived stem cells help heal burns but need more research.
August 2023 in “International Journal of Molecular Sciences” Human skin xenografting could improve our understanding of skin development, renewal, and healing.
3 citations,
May 2024 in “Frontiers in genetics” The protein STAT3 slows down cell growth by blocking the FST gene, which affects hair development in sheep.
28 citations,
November 2018 in “Journal of Cellular and Molecular Medicine” CXXC5 is a protein that controls cell growth and healing processes, and changes in its activity can lead to diseases like cancer and hair loss.
6 citations,
November 2022 in “Development” New research shows that skin diversity is influenced by different types of dermal fibroblasts and their development, especially involving the Wnt/β-catenin pathway.
Genetic analysis of rabbits identified key genes for traits like coat color, body size, and fertility.
May 2019 in “Journal of Investigative Dermatology” Combining platelet-rich plasma injections and gel may effectively treat morphea, improving skin elasticity and reducing pain.
May 2018 in “Journal of Investigative Dermatology” The study found that p63 needs signals from morphogens to help skin cells differentiate properly.
October 2017 in “Journal of Investigative Dermatology Symposium Proceedings” Using lidocaine before keloid injections makes the treatment more comfortable for patients.
7 citations,
June 2021 in “Trends in Food Science and Technology” Western diet may cause male pattern baldness; low glycemic diet with magnesium could help.
13 citations,
September 2019 in “Biological & Pharmaceutical Bulletin” Certain flavonoids help grow back colored hair after skin injury.
November 2023 in “npj regenerative medicine” Skin spheroids with both outer and inner layers are key for regrowing skin patterns and hair.
2 citations,
February 2019 in “Journal of Investigative Dermatology” Higher levels of the DP2 receptor may lead to hair loss.
1 citations,
July 2018 in “Elsevier eBooks” Heredity and hormones cause common hair loss, and topical minoxidil is the first recommended treatment.
23 citations,
October 2018 in “Expert Opinion on Drug Safety” Consider benefits and risks of new alopecia treatments for safety.
23 citations,
May 2016 in “American Journal of Pathology” The research suggests that a specific skin gene can be controlled by signals within and between cells and is wrongly activated in certain skin diseases.
19 citations,
November 2018 in “Experimental Dermatology” The spiny mouse can regenerate its skin without scarring, which could help us learn how to heal human skin better.