26 citations
,
December 2019 in “Stem Cell Reports” This study found that transient hypomethylation of histone H3 K4/9/27me3 is crucial for the proper dynamics of adult skin epithelial stem cells and effective tissue repair in mice.
10 citations
,
February 2023 in “Colloids and surfaces. A, Physicochemical and engineering aspects” This study found that a wound dressing made from egg white proteins, polyvinyl alcohol, and 1 mg/ml graphene oxide was most effective in promoting skin wound healing and tissue regeneration.
2 citations
,
February 2024 in “Pharmaceutics” This review highlights that while chitosan-based wound dressings with silver nanoparticles show promise for treating infected wounds due to enhanced antimicrobial activity, further studies are needed to address their in vivo toxicity and evaluate their efficacy in infectious animal models.
908 citations
,
July 2015 in “British Journal of Dermatology” This article reviews the cellular and molecular processes of acute and chronic wound healing, emphasizing the need for collaboration between researchers and clinicians to advance therapeutic solutions; it presents no new clinical results.
305 citations
,
March 2018 in “International journal of molecular sciences” In this review, the authors summarize classical and recent insights into the biology and treatment of hypertrophic scars and keloids, concluding that while understanding and strategies have advanced, effective prevention and treatments remain unsatisfactory.
202 citations
,
August 2007 in “Biomaterials” This review discusses advancements in artificial skin for wound treatment and reports no new clinical findings; the authors highlight the potential of new biomaterials to enhance future skin replacement therapies.
178 citations
,
August 2016 in “Advances in wound care” This article discusses advancements in understanding how skin stem cells and fibroblasts contribute to scar formation, highlighting current and potential therapies aimed at preventing or reducing scarring, yet notes that effective treatments without significant side effects are still lacking.
113 citations
,
June 2019 in “F1000Research” This review discusses the mechanisms of wound healing and excessive scarring, highlighting the importance of understanding these processes for developing new therapies to prevent fibrotic scarring in large skin wounds.
45 citations
,
August 2018 in “Haematologica” This study found that iron retention in macrophages impairs hair follicle growth and delays wound healing in mice, highlighting the importance of macrophage iron release for skin health.
25 citations
,
November 2022 in “Frontiers in Bioengineering and Biotechnology” This review discusses the integration of biodegradable biomaterials with drugs and stem cells for diabetic wound repair, but reports no new clinical results and highlights the need for further translation to clinical practice.
16 citations
,
August 2019 in “Journal of the Chinese Medical Association” This study reported that adipose-derived stem cells may promote burn wound healing and skin appendage regeneration in a rat model, suggesting a potential approach for improving burn treatments.
12 citations
,
April 2020 in “Facial Plastic Surgery Clinics of North America” This article discusses potential complications in hair restoration surgery and emphasizes the importance of thorough planning and patient participation in reducing risks, but reports no new clinical findings.
11 citations
,
October 2018 in “Nucleic Acid Therapeutics” This study suggests that transfection with modified KGF-mRNA enhances keratinocyte reepithelialization in wound therapy by temporarily increasing growth factor expression without affecting nuclear DNA.
10 citations
,
August 2022 in “International Journal of Molecular Sciences” This review discusses mechanisms of wound healing impairment in leptin-deficient murine models used for diabetic research, and reports no new clinical results; the authors emphasize the need for further study.
1 citations
,
November 2023 in “Biomaterials advances” This study found that combining mesenchymal stromal cells from adipose tissue and hair follicles with soy protein and β-chitin scaffolds significantly reduced wound healing time and improved skin regeneration in vivo.
June 2025 in “Problems of Cryobiology and Cryomedicine” In this study, the researchers found that tyndallization effectively sterilizes aqueous solutions of hyaluronic acid without diminishing their regenerative properties, and these properties remain intact even at low temperatures, supporting potential applications in cryobiology and cryomedicine.
July 2004 in “Clinics in Dermatology” This research introduced and validated the Scales of General Well-Being, which reliably measures overall and specific aspects of well-being across different demographics in North America.
132 citations
,
April 2021 in “Stem Cell Research & Therapy” This study found that exosome-incorporated human amniotic membrane scaffolds notably enhanced diabetic skin wound healing in mice, suggesting potential applications for ADSC-derived exosomes in clinical settings.
16 citations
,
February 2014 in “Journal of Investigative Dermatology” This study developed a mouse model to monitor hair follicle cycling macroscopically through live bioluminescence imaging, enabling detailed analysis of hair cycle and propagation dynamics influenced by environmental factors.
10 citations
,
November 2023 in “Frontiers in Pharmacology” In this study, researchers developed a self-assembling hydrogel called RADA-PDGF2 and found it to accelerate wound closure in a mouse model due to its pro-proliferative and pro-migratory properties, without causing cytotoxicity or immunogenicity.
2 citations
,
June 2006 in “Experimental dermatology” This article discusses the development of skin patterns during embryogenesis and postnatal life, linking them to genetic, environmental, and mathematical factors, but presents no new empirical findings.
February 2026 in “Preprints.org” This review synthesizes the latest advances in wound healing and scar management, exploring molecular mechanisms, therapeutic strategies, and providing an evidence-based comparison of topical agents like Dermatix Ultra and Contractubex for scar improvement, aimed at informing clinicians and patients in decision-making.
June 2014 in “Wound Medicine” This review discusses evaluation and treatment options for polycystic ovary syndrome and reports no new clinical results; it emphasizes a multi-system approach using the mnemonic "MY PCOS.
22 citations
,
November 2024 in “Bioactive Materials” This study found that 3D-printed polyamine-modified hydrogels facilitate M2 macrophage polarization and exosome secretion, enhancing skin cell compatibility and promoting wound healing and hair follicle induction in an animal model through specific signaling pathways, suggesting potential for skin disorder therapies.
162 citations
,
July 2011 in “Biomacromolecules” This study found that chitosan nanofibrillar scaffolds accelerated skin wound healing in mice by enhancing cell adhesion, proliferation, and regeneration of epidermis and dermis compared to other forms.
99 citations
,
January 2014 in “Nature communications” In this study, researchers developed a method to differentiate human iPSCs into cells that can generate all lineages of hair follicles, potentially aiding treatments for hair loss and skin disorders.
63 citations
,
June 2023 in “Journal of Nanobiotechnology” In this study, researchers developed a 3D chitosan/polyvinyl alcohol-tannic acid nanofiber sponge that demonstrated effective hemostatic, antibacterial, and antioxidant properties without antibiotics, accelerated wound healing in vivo, and showed high biocompatibility with L929 cells, highlighting its potential as a wound dressing for clinical use.
57 citations
,
July 2018 in “Scientific Reports” This study found that prevascularizing dermal matrices with adipose tissue-derived microvascular fragments improved vascularization and allowed earlier successful skin grafting in a bradythrophic wound model.
57 citations
,
December 2012 in “Molecules” This study found that mahanimbicine and a crude extract of Murraya koenigii may enhance wound healing in rats by promoting faster wound contraction and higher collagen deposition.
54 citations
,
May 2021 in “International Journal of Molecular Sciences” This review discusses recent advances in scarless wound healing research, focusing on the roles of mechanobiology and immunology, and reports no new clinical results; the authors highlight the potential of next-generation human skin equivalents in understanding these mechanisms.