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This study found that maintaining a low level of Wnt/β-catenin activity is crucial for mammary gland development, as excessive activity inhibits branching and promotes characteristics of hair follicles instead, highlighting its role in skin appendage identity decisions.

This study found that inhibiting AP-1 transcription factors in mice causes squamous tumors to transform into sebaceous tumors and regulates tumor cell lineage.

This study found that inhibiting AP-1 activity in mice can induce lineage transdifferentiation between squamous and sebaceous tumors, suggesting AP-1's role in maintaining tumor cell identity.

This study concludes that anti-androgenic chemicals causing short anogenital distance in male fetuses also induce a feminized transcriptional profile in the perineum, implicating Wnt and estrogen signaling in the process.

This review discusses the roles of key developmental signaling pathways in mammalian skin repair compared to skin development, and suggests these insights could lead to better wound healing therapies, but it reports no new findings.

This review discusses the regulation and dynamics of the Wnt/β-catenin signaling pathway in development, pluripotency, and cancer, highlighting potential mechanisms and future research directions, but reports no new results.

This study found that Wnt10b promotes the proliferation of hair follicle stem cells and hair precortex cells, revealing them as target cells in Wnt10b-induced hair follicle regeneration.

In this study, one type of commercial culture medium supported expression of stem cell markers in hair follicle epithelial stem cells, but their differentiation potential and hair follicle-inducing ability declined over time.

This study found that RSPO1, a Wnt/β-catenin pathway agonist, significantly induces insulin-producing β cell replication and neogenesis in various settings, offering a promising potential therapy for diabetes.

This study found that GTx-024 and Danazol had similar effects to dihydrotestosterone on uterine tissue in mice, while GTx-007 showed minimal impact on the parameters tested.

This study found that the Wnt inhibitor Dkk4 may play a role in regulating hair follicle development through a feedback loop with canonical Wnt signaling pathways.

In this mouse study, the absence of the Ascl4 gene did not affect the development of hair follicles, teeth, or mammary glands, suggesting it is non-essential for these processes.

This study demonstrated that a combination of four types of honey significantly improved hair integrity, porosity, and surface roughness after exposure to UV-A and pollution stress.

Blocking DPP4 can help prevent fat loss and skin fibrosis.

The review discusses the diverse roles of WNT10B in mammary gland development, immune function, and its potential implications in cancer and regenerative processes, with no new experimental results.

Wnt-10b helps skin cells and hair grow.

This study systematically reviews the Wnt/β-catenin signaling pathway, discussing its origin, composition, function, involvement in tumors and diseases, and the development of small-molecular compounds targeting this pathway for disease treatment.

This study found that Wnt10b promotes melanocyte maturation and pigmentation in the hair bulbs of mice by activating canonical Wnt signaling.

This study observed that Wnt5a mRNA expression in mice correlates with the hair cycle and inhibits hair follicle growth by antagonizing the Wnts pathway.

This study found that Wnt5a suppresses β-catenin signaling, inhibiting the transition of hair follicles from the telogen to anagen phase.

This study identified WNT10A as crucial for adult epithelial cell proliferation and differentiation, suggesting β-catenin pathway activation may help address regenerative defects in WNT10A mutation patients.

This study found that WNT signaling is essential for the initiation of mammary gland morphogenesis in embryonic mice, promoting placode development and potentially playing a critical role in skin appendage formation.

This study found that Wnt10b induces hair follicle regeneration in mice, likely by activating the canonical Wnt signaling pathway in stem cells and their daughter cells.

This study reported that Dkk4-knockout mice showed disrupted hair follicle patterning, suggesting a WNT-DKK axis may influence regional specificities in hair follicle induction related to androgenetic alopecia.

Wnt-10b helps skin cells develop into hair-related structures.

This review discusses the roles and mechanisms of Wnt signaling in embryonic and adult stem cells and its association with cancers, and reports no new experimental findings.

This study found that overexpression of sFRP4 in skin cells reduces Wnt signaling activation, leading to decreased melanocyte differentiation in regenerating hair follicles.

This study demonstrates that Wnt signaling plays a crucial mechanoregulatory role in skin regeneration by influencing cellular responses to substrate rigidity, which promotes hair follicle regeneration in the wound-induced hair neogenesis model.