29 citations
,
April 2020 in “Journal of Tissue Engineering and Regenerative Medicine” This study demonstrates that incorporating human neopapilla into reconstructed human skin can initiate hair follicle morphogenesis by stimulating epidermal invagination and maintaining follicle-inductive properties in vitro.
25 citations
,
May 2013 in “Journal of mammary gland biology and neoplasia” This review examines the roles of Hedgehog and Gli proteins in mouse embryonic mammary development and suggests that Gli3-repressor-mediated off-state of Hedgehog signaling determines mammary fate over hair follicle fate.
21 citations
,
December 2013 in “Archives of Dermatological Research” No link found between new male baldness genes and female hair loss.
20 citations
,
July 2013 in “European Journal of Oral Sciences” This study found a novel PAX9 gene mutation that may cause tooth agenesis and trichodysplasia in a studied family.
10 citations
,
August 2018 in “Experimental Dermatology” This study found that DECORIN promotes the proliferation and migration of outer root sheath keratinocytes in vitro and maintains the hair anagen phase in mice.
5 citations
,
September 2015 in “BMC Medical Genetics” In this study, individuals with a c.1072C > T mutation in the EDAR gene showed more hair shaft deformations compared to non-mutation carriers, highlighting EDAR's role in hair follicle development.
3 citations
,
September 2022 in “Archives of dermatological research” In this study, fractional CO2 laser treatment for alopecia areata was found to significantly increase terminal hair and patient satisfaction compared to betamethasone valerate cream alone, highlighting its efficacy and safety both as a standalone and combined treatment.
3 citations
,
February 2016 in “Nature Biotechnology” New drug shows promise for better hair growth in baldness treatment.
3 citations
,
January 2012 in “Wageningen Academic Publishers eBooks” This article discusses the complex biological functions and social significance of hair follicles and reports no new research findings, emphasizing their role in health, disease, and a substantial beauty industry.
2 citations
,
January 2018 in “International Journal of Biochemistry & Physiology” This study identified two new Wnt genes, EsWnt1 and EsWnt4, in red starfish, with their expression patterns suggesting a role in wound healing and regeneration.
January 2024 in “Regenerative Biomaterials” In this study, researchers developed a biodegradable microneedle made of hyaluronic acid, intended to enhance drug delivery through the skin's stratum corneum and potentially promote hair growth by overcoming the skin's barrier function in alopecia treatment.
February 2026 in “Frontiers in Pharmacology” This review suggests a shift toward genetically informed treatments for male pattern hair loss by integrating genetic insights and pharmacogenetic markers into therapeutic decision-making.
September 2025 in “Animal Bioscience” This study found that triglyceride and energy metabolic pathways are crucial factors influencing wool fiber diameter in fine-wool Alpine Merino sheep, providing insights for enhancing wool quality.
In this open uncontrolled study on microneedling as an adjuvant therapy for frontal fibrosing alopecia, researchers observed stable frontotemporal recession measurements while patients reported improvements in quality of life and a reduction in inflammatory activity parameters.
This study reports that in Rex rabbits, age affects fur quality and hair follicle traits, with the Wnt signaling pathway playing a role in their periodic hair follicle development.
This research describes a crucial role for Meis2 expression in mesenchymal cells derived from the neural crest for whisker formation, showing that whiskers can develop without sensory innervation or FOXD1 expression, highlighting an early function of MEIS2.
March 2024 in “Research Square (Research Square)” This study found that in sheep, the microRNA oar-miR-377 regulates hair follicle development by targeting the SLC24A2 gene, and identified a genetic variation associated with wool quality, suggesting potential markers for breeding.
October 2021 in “Research Square (Research Square)” This study found that in hairpoor mice, disruptions in hair follicle stem cell quiescence and signaling pathways lead to disturbed hair cycles, which may help explain alopecia development in Marie-Unna Hypotrichosis patients.
June 2017 in “Experimental and Therapeutic Medicine” In a depilated mouse model, this study found that blocking CXCL4 activity with an anti-CXCL4 monoclonal antibody promoted hair growth by inducing an earlier anagen phase, delaying hair follicle regression, and altering expression of genes and proteins related to hair growth and cell proliferation.
January 2004 in “Enshou saisei” This study observed that follistatin and activin interactions significantly influence hair follicle development in mice, suggesting potential regenerative treatments for alopecia.
June 2021 in “Journal of Cosmetic Dermatology” Laser treatment shows promise for hair growth, but needs further research.
2 citations
,
August 2022 in “Frontiers in Endocrinology” This study reported that myeloid-specific Wnt production did not affect wound healing or blood vessel density in mice but influenced endovascular progenitor cell kinetics during angiogenesis.
April 2026 in “International Journal of Molecular Sciences” This review synthesizes recent research on how Wnt signaling regulates skin, hair follicle, and nail regeneration, highlighting its compartment-specific roles and discussing targeted strategies for treating conditions like alopecia, chronic wounds, and skin cancer.
59 citations
,
November 2010 in “Circulation Research” This review discusses the potential role of Wnt signaling in aging-related heart diseases and reports no clinical results.
6 citations
,
December 2017 in “Molecular Medicine Reports” This study found that Wnt5a expression may suppress cell differentiation and induce an inflammatory response in HaCaT keratinocytes, which could be relevant to psoriasis development.
This study identified ISX9 as a novel agonist of the Wnt/β‐catenin pathway, which promoted hair regrowth in mice and may offer a therapeutic approach for alopecia.
May 2015 in “Journal of Investigative Dermatology” In this study, Wnt-3a was found to play an important role in partially maintaining and expanding epithelial skin stem cells in vitro, suggesting potential for in vitro stem cell culture without feeder cells.
75 citations
,
August 2008 in “PLOS ONE” This study found that Wnt3a liposomes can induce hair follicle neogenesis when delivered subcutaneously, demonstrating their potential for regenerative applications.
9 citations
,
May 2014 in “Journal of Cardiovascular Development and Disease” This review discusses the role of Wnt signaling in cardiac development and explores attempts to modulate it for improving heart function after ischemic injury, but reports no new experimental results.
2 citations
,
January 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that androgen signaling can inhibit Wnt-stimulated growth in prostate basal cell organoids, suggesting a key role in regulating their multipotency.