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This study observed that activating Wnt signaling pathways increased the efficiency of reprogramming human fibroblasts into induced pluripotent stem cells compared to untreated cells.

This study found that Enz_MoriL, a compound derived from Morus alba L., promotes hair follicle cell proliferation by affecting the Wnt/β-catenin pathway and can counteract an alopecia areata-like condition by suppressing the JAK-STAT signaling in human hair follicle dermal papilla cells.

In this mouse study, nitrate supplementation at 10mM was observed to significantly promote hair growth by increasing hair follicle number and dermis thickness, and it may work by activating the Wnt/β-catenin pathway and inhibiting TGF-β1 signaling.

This study found that strontium ranelate promotes cartilage regeneration in rats by enhancing chondrogenic differentiation of bone mesenchymal stem cells while inhibiting the Wnt/β-catenin signaling pathway.

This study found that strontium ranelate may promote cartilage regeneration by enhancing chondrogenic differentiation and inhibiting the Wnt/β-catenin signaling pathway in rat models of cartilage defects.

This study observed that Icariside II, an extract from Epimedium brevicornu Maxim, can inhibit the growth of gastric cancer in cell lines and mouse models by promoting apoptosis and suppressing the Wnt/β-catenin signaling pathway, with minimal toxicity to normal gastric cells.

This study found that LGR5 is uniquely expressed in human corneal endothelial cells and maintains endothelial cell phenotypes while inhibiting mesenchymal transformation through the Wnt pathway.

This study found that UC.145 influences DKK1 methylation and Wnt signaling in gastric cancer, with implications for patient survival and its potential as a predictive biomarker.

This study found that exosomes derived from human amniotic mesenchymal stem cells enhanced stem cell proliferation and structural restoration in irradiated salivary glands of rats, with significant improvements observed by day 7, suggesting activation of the Wnt signaling pathway.

This study reported that high-intensity red LED irradiation increased osteogenic differentiation and mineralization of human bone marrow mesenchymal stem cells, potentially through Wnt/β-catenin pathway activation.

This review discusses the role of the CXXC5 protein as a transcription factor and signaling coordinator, noting its involvement in embryonic development, tissue homeostasis, and diseases such as tumorigenesis, but reports no new experimental findings.

This review discusses the roles of key developmental signaling pathways in mammalian skin repair compared to skin development, and suggests these insights could lead to better wound healing therapies, but it reports no new findings.

This study generated FGF5-knockout Dorper sheep using the CRISPR/Cas9 system, resulting in significantly increased fine-wool and active hair-follicle density, and explored downstream signaling pathways for potential applications in androgen alopecia treatment.

This study found that insulin promotes corneal epithelial wound healing and nerve recovery in diabetic mice through Wnt signaling, suggesting its potential as a protective factor for diabetic corneal damage.

This review discusses various Wnt pathway modulators developed between 2014 and 2020, highlighting their potential as treatments for diseases like cancer and osteoarthritis, but reports no new clinical results.

Drugmakers are optimistic about targeting the Wnt pathway for new treatments despite past challenges.

This review discusses the similarities between wound healing and embryonic development, focusing on signaling pathways and their potential for developing new wound healing strategies, and reports no new clinical results.

This review examines androgenetic alopecia, detailing its causes and current treatments, but reports no new clinical results; the authors emphasize understanding its complexity for personalized therapy development.

This study found that in Pomeranians with Alopecia X, key genes in the Wnt and Shh signaling pathways and stem cell markers are downregulated, which may explain the absence of anagen hair follicles.

This study suggests that the long noncoding RNA H19 helps dermal papilla cells maintain their hair follicle-inducing ability by activating the Wnt signaling pathway, potentially offering a therapeutic target for androgenetic alopecia.

This review discusses the role of Hedgehog signaling in epidermal and hair follicle development and its involvement in basal cell carcinoma, without reporting new empirical findings.

This study found that mice lacking the Vitamin D receptor showed disrupted hair follicle cycling, which was partially restored with hedgehog signaling pathway activation, suggesting a role for this pathway in follicle regulation independent of vitamin D.

This study found that DKK1 and WNT10b are paracrine factors that modulate hair follicle stem cell differentiation inhibition, contributing to androgenetic alopecia by affecting Wnt signaling in androgen-sensitive dermal papilla cells after dihydrotestosterone stimulation.

This study found that applying TPA to mice accelerated hair follicle regeneration by activating Akt and Wnt/ß-catenin signaling pathways, involving hair follicle stem cell proliferation.