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This study found that microRNAs play key roles in regulating gene expression during the hair cycle in mice, impacting follicle growth and skin homeostasis through mechanisms involving major signalling pathways.

This study found that DKK1-targeting siRNA, which may activate the Wnt/β-catenin signaling pathway, showed hair growth results in mice similar to those treated with the FDA-approved minoxidil, suggesting potential as an androgenetic alopecia therapy.

This study found that treating secondary hair follicle stem cells from Arbas cashmere goats with 10 μg/mL quercetin for 48 hours significantly boosted cell proliferation and reduced apoptosis by activating several signaling pathways, suggesting a potential strategy to enhance cashmere production.

This study found that treating secondary hair follicle stem cells from Arbas cashmere goats with quercetin at 10 μg/mL for 48 hours significantly enhanced cell proliferation and reduced apoptosis, suggesting potential strategies to improve cashmere production through various signaling pathways.

This study found that ocu-miR-205 promotes changes in signaling pathways and shifts in hair follicle phases, affecting Rex rabbit hair density by increasing secondary follicles.

This study investigated using baricitinib-loaded mesenchymal stem cell exosomes injected locally in an alopecia areata mouse model and found that this method improved hair regrowth better than baricitinib or exosomes alone, potentially offering a new therapeutic approach for treating alopecia areata.

In this study, researchers developed a new human in vitro model for male androgenetic alopecia that replicates key features of the disorder, providing an effective platform for studying hair loss mechanisms and testing potential treatments.

This study showed that exosomes from hyaluronic acid-primed induced mesenchymal stem cells promote hair growth by enhancing proliferation and migration of hair follicle dermal papilla cells and modulating key growth factors and signaling pathways, potentially counteracting the effects of DHT-induced hair loss.

This study found that exosomes from hyaluronic acid-primed mesenchymal stem cells may promote hair growth in androgenetic alopecia by improving hair follicle cell function and restoring key signaling pathways disrupted by DHT.

This study found that linoleic acid from Malva verticillata seed extracts may promote hair follicle cell growth and counteract hair loss signaling in a lab setting.

In this study, researchers found that miR-199a-3p plays a regulatory role in hair follicle development via the PTPRF/β-catenin axis and established a mouse model of alopecia areata by downregulating this small RNA, suggesting its potential value in studying alopecia diseases.

In this study on fine-wool sheep, researchers found that overexpressing the TGFBR1 gene decreased proliferation of dermal papilla cells by influencing multiple signaling pathways, suggesting TGFBR1 as a negative regulator in hair follicle development.

This review discusses the conserved molecular mechanisms controlling hair follicle development and cycling and suggests they may also apply to other ectodermal derivatives, like teeth and feathers, but it reports no new results.

In this study, researchers observed that deleting the Gpr54 gene accelerated the hair cycle and enhanced hair regeneration in mice by modifying the NAFTc3-SFRP1-Wnt signaling pathway, suggesting Gpr54 as a potential target for hair loss treatments.

This review discusses the roles of the hairless (HR) protein as a corepressor, particularly its impact on RORα-mediated transcriptional repression, and reports no new experimental findings.

In this study, researchers identified three proteins, DEFB1, HGFAC, and CYB5D2, as potential drug targets for alopecia areata, and suggested that the traditional Chinese medicine ingredient cimigenol shows promise in interacting with DEFB1 for potential treatment.

This study found that Cyanidin-3-O-glucoside and Vitisin A were able to penetrate mouse skin and improve issues related to hair follicle miniaturization and apoptosis in androgenetic alopecia, suggesting these compounds as potential alternative treatments for hair loss.

In a mouse model study, researchers developed a methacrylated hyaluronic acid-based hydrogel microneedle patch co-loaded with finasteride and a carbon monoxide-releasing molecule for androgenetic alopecia, which showed better hair regrowth and safety compared to traditional treatments, offering an innovative approach with minimized systemic side effects.

This study reported that human umbilical cord mesenchymal stem cell-derived exosomes may promote hair regeneration and thickness in androgenic alopecia by modulating cellular pathways in hair growth, including increasing hair density and diameter, as observed in a mouse model and an exploratory clinical trial.

This source reported that early evidence supports the potential efficacy of exosomes in treating conditions like alopecia, facial rejuvenation, hyperpigmentation, and scarring, but noted that standardization issues need addressing through further studies to better understand their use in aesthetic dermatology.

This study observed that a topical serum containing Silybum marianum extract, manganese PCA, and Lespedeza capitata extract enhanced hair follicle growth and hair shaft elongation, while prolonging the anagen phase in an ex vivo human scalp skin model, suggesting potential benefits for hair loss treatment.

This study found that vitamin A significantly enhanced the proliferation and inhibited apoptosis of rabbit dermal papilla cells under heat stress, likely by modulating miR-195/IGF1 and Wnt10b/β-catenin signaling pathways.

This review highlights how natural products with antioxidant properties can modulate the Wnt signaling pathway, potentially influencing various pathological conditions such as cancer, stroke, and regenerative medicine. It also addresses controversies in the compounds' mechanisms across different models and suggests research directions for future studies.

This study found that microneedling-induced microinjury in mice promoted hair growth by stimulating the TNF-α/Wnt/VEGF pathway, and blocking TNF-α inhibited this process.

This study found that linoleic acid from Malva verticillata seed extracts may promote hair growth and alleviate androgenic alopecia by activating the Wnt/β-catenin signaling pathway in dermal papilla cells.

In this study, norgalanthamine was found to stimulate hair growth in cultured rat dermal papilla cells by activating the ERK 1/2, PI3K/AKT, and Wnt/β-catenin signaling pathways.

In this study, a 5% Gymnema sylvestre leaf extract formulation applied to C3H mice showed significantly delayed hair regrowth by increasing TGF-β1 and TGF-β2 expression while reducing β-catenin levels, suggesting its potential as a natural hair growth inhibitor.

This study suggests that the MLKL-targeting inhibitor Necrosulfonamide promotes hair growth and counteracts DHT inhibition by activating Wnt signaling in hair follicle cells, revealing potential avenues for anti-alopecia drug development.

This study found that recombinant oleosin-hFGF5 expressed in Arabidopsis can inhibit hair regeneration by decreasing the proliferation of hair follicle epithelial cells.

This study found that WNT signaling is essential for the initiation of mammary gland morphogenesis in embryonic mice, promoting placode development and potentially playing a critical role in skin appendage formation.