16 citations
,
January 2023 in “Molecular Biomedicine” This study demonstrated that customized microneedle arrays can precisely induce targeted hair regeneration and improve hair quality in mice, potentially offering a personalized treatment approach for hair loss.
16 citations
,
July 2020 in “International Journal of Molecular Sciences” This study found that ruxolitinib modulated inflammatory changes and stimulated growth factor signals by blocking the JAK-STAT pathway in an in vitro model of alopecia areata.
15 citations
,
February 2015 in “Cell & tissue research/Cell and tissue research” This review examines the role of P-cadherin in skin and hair biology, emphasizing its importance in human hair growth, cycling, and pigmentation, and reports no new research findings.
12 citations
,
October 2020 in “Scientific Reports” In this study, Nec-1s was found to promote hair growth and may target necroptosis and the Wnt/β-catenin pathway for potential treatment of hair loss.
4 citations
,
January 2020 in “Frontiers in Physiology” This review discusses molecular signaling pathways and nutritional factors influencing feather growth and regeneration in poultry and offers no new results; the authors suggest these insights may guide strategies for producing superior plumage.
March 2026 in “Trends in Sciences” This study developed a testosterone propionate-induced C57BL/6 mouse model of androgenetic alopecia, demonstrating that high-dose, prolonged testosterone administration inhibited hair regrowth and mirrored human AGA pathology, providing a useful platform for studying hair loss mechanisms and testing therapies targeting the Wnt/β-catenin pathway.
77 citations
,
July 2012 in “Journal of Investigative Dermatology” The researchers observed that overexpression of Wnt10b in a mouse model can induce hair follicle regeneration by switching follicles from the resting phase to the growth phase via the Wnt-β-catenin signaling pathway.
26 citations
,
November 2016 in “European Journal of Clinical Pharmacology” This study found that using valproic acid during radiotherapy for glioma was associated with delayed hair loss and improved survival outcomes.
14 citations
,
March 2019 in “Journal of Cosmetic Dermatology” This laboratory study found that activated platelet‐rich plasma supernatant enhanced hair growth signaling pathways in cultured human dermal papilla cells, suggesting potential for treating androgenic alopecia.
9 citations
,
December 2002 in “Novartis Foundation Symposium” In this research, LEF1 was identified as a crucial transcription factor for submucosal gland development in mouse and ferret tracheas, though it requires other factors to induce gland formation.
4 citations
,
October 2018 in “Cell Stem Cell” This study shows that differences in Hoxc gene expression in hair follicle mesenchyme along the body axis contribute to regional variations in mammalian hair growth.
4 citations
,
November 2015 in “Journal of Investigative Dermatology” This study found that filamin A plays a crucial role in fibroblasts' ability to sense and respond to mechanical stimuli, significantly affecting wound closure and fibroblast-mediated processes in mice.
2 citations
,
November 2023 in “Bioactive materials” The researchers reported that a newly developed ionic liquid-based microemulsion significantly improved the local delivery of copper peptides in mice, enhancing hair growth-related factor activation while offering a safer, non-invasive alternative to existing treatments for hair loss.
January 2026 in “Cosmetics” This study highlights emerging regenerative strategies, such as stem cell-derived therapies and machine learning tools, that may advance hair loss treatment beyond traditional methods by promoting follicle regeneration and offering personalized care.
June 2025 in “Medical & Clinical Case Reports Journal” This systematic review concludes that exosomes may offer significant therapeutic potential for treating androgenetic alopecia, with observed improvements in hair density and follicular health, but further long-term clinical studies are necessary for validation.
November 2024 in “Stem Cell Research & Therapy” This study found that human umbilical cord mesenchymal stem cells (hUCMSCs) promoted hair regeneration in androgenetic alopecia model mice by activating Wnt/β-catenin signaling, enhancing hair follicle stem cell proliferation, and reducing dermal papilla cell apoptosis.
159 citations
,
January 2006 in “BMC Cell Biology” This study found that manipulating Wnt signaling pathways in cutaneous wounds can induce skin structures resembling regeneration, suggesting a potential role for Wnt signals in restoring skin architecture during wound healing.
May 2024 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers found that both Wnt/β-catenin and Hedgehog signaling pathways must be activated in wound fibroblasts to promote hair follicle neogenesis in mice, suggesting these pathways are crucial for regenerative healing strategies.
April 2017 in “Journal of Investigative Dermatology” This study observed that using a 1064 nm Nd: YAG laser may stabilize hair loss and promote new growth in some females with frontal fibrosing alopecia, though individual results varied.
October 2021 in “Research Square (Research Square)” This study found that gene expression patterns can effectively distinguish the cashmere growth cycle stages and highlight molecular pathways, suggesting melatonin's role in regulating cashmere growth in Inner Mongolian goats.
16 citations
,
July 2021 in “Histopathology” This review discusses recent findings on molecular changes in cutaneous adnexal tumours and reports novel markers and pathways involved, highlighting the diverse oncogenic drivers and tumour suppressor alterations.
January 2025 in “Institutional Repositories DataBase (IRDB)” This study observed that topical application of maslinic acid stimulated hair growth in mice comparably to minoxidil, possibly through the Wnt/β-catenin pathway and involving ciliary gene activity, highlighting increased levels of trichogenic gene expression and protein levels.
This study found that gels containing glycyrrhizic acid and aqueous Glycyrrhiza glabra extract significantly reduced underarm hair growth in terms of area, thickness, length, and number compared to their gel bases.
205 citations
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August 2007 in “Experimental Cell Research” This review discusses advances in understanding mammalian stem cell niches, particularly in bone marrow, tooth, and hair follicle, and highlights the potential for developing therapies targeting these niches for tissue repair.
March 2024 in “Journal of Microbiology and Biotechnology” This study suggests that phloroglucinol may enhance anagen signaling and reduce oxidative stress-induced damage in human dermal papilla cells, offering a potential therapy for hair loss.
April 2018 in “Journal of Investigative Dermatology” This study found that arrector pili muscles formed by Sonic Hedgehog signaling play a critical role in maintaining sympathetic nerve connections to hair follicle stem cells, influencing hair regeneration, with implications for hair loss treatments.
9 citations
,
January 2016 in “International Journal of Medical Sciences” This study found that Wnt10b promotes the proliferation of hair follicle stem cells and hair precortex cells, revealing them as target cells in Wnt10b-induced hair follicle regeneration.
14 citations
,
July 2017 in “Fitoterapia” In this study, oleanolic acid was found to enhance hair follicle growth and promote hair matrix cell proliferation via the Wnt/β-catenin pathway in a human hair follicle organ culture model.
2 citations
,
November 2011 in “InTech eBooks” This article reviews the types and characteristics of adrenal cortex tumors, including their hormone secretion and detection as incidental findings, but presents no new research results.
1039 citations
,
February 2009 in “Nature Reviews Molecular Cell Biology” This review discusses the reuse of molecular mechanisms involved in embryonic skin development for maintaining adult epidermal homeostasis and reports no new results.