July 2025 in “International Journal of Dermatology Venereology and Leprosy Sciences” In this review, researchers examined the concentration of cortisol in scalp hair of individuals with alopecia areata to explore its relationship with disease variables, as cortisol in hair can indicate chronic stress, which may impact alopecia areata pathogenesis.
This study suggests that while alopecia areata presents similarly across different skin tones, hair loss may be underestimated in individuals with more tightly coiled hair without a comprehensive examination, highlighting the need for culturally sensitive evaluation approaches, particularly for Black women.
May 2025 in “Life Studies” In this study, lung cancer patients undergoing treatment with immune checkpoint inhibitors and chemotherapy reported high incidence and severity of symptoms such as fatigue, drowsiness, and loss of appetite, which were most prominent and distressing throughout the treatment cycles.
In this study, researchers found that CD4 T cells from the skin draining lymph nodes of mice with alopecia areata can transfer the disease to recipient mice, highlighting the key role of these cells and their interaction with CD8 T cells in the disease's development.
February 2025 in “Theranostics” In this study, researchers used 3D bioprinting with skin stem cells and specific hydrogels to create artificial skin that successfully promoted complete wound healing and the regeneration of skin structures, including hair follicles and blood vessels, in mice.
January 2025 in “SKIN The Journal of Cutaneous Medicine” This study suggests that while vitamin D3 deficiency is linked to alopecia areata severity, evidence for the effectiveness of supplementation or topical calcipotriol treatment remains inconsistent and low quality.
January 2025 in “International Journal of Dermatology Venereology and Leprosy Sciences” This review discusses the various off-label treatments for alopecia areata, highlighting that these therapies may promote hair growth but are not curative.
December 2024 in “Nordisk tidsskrift for helseforskning” In this study, researchers explored how alopecia areata impacts daily life, identifying key themes such as fear of hair replacement failure, workplace challenges, lack of understanding, and acceptance of hair loss, ultimately highlighting that living with visible physical changes alters everyday experiences.
November 2024 in “Cureus” This case report described a 43-year-old male with trichotillomania, experiencing severe alopecia and an ulcerated plaque, who improved with a combination of antibiotic, antidepressant, and psychotherapy treatments, suggesting that these interventions may benefit individuals with psychiatric comorbidities linked to this condition.
October 2024 in “Journal of Education Health and Sport” This article reviews treatment options for Alopecia Areata, concluding that topical corticosteroids are effective for mild cases, while systemic therapies are advised for moderate to severe cases.
July 2024 in “Plastic and Aesthetic Research” This review outlines diagnostic strategies and a thorough checklist for evaluating patients before they undergo hair restoration surgery, addressing non-scarring and scarring alopecia, to improve surgical outcomes and avoid errors, according to this source.
July 2024 in “Dermatology and Therapy” This study found that individuals with black hair have a significantly higher risk of alopecia areata compared to those with dark brown hair, while lighter hair colors like red or blonde are associated with a lower risk.
June 2024 in “Dermatology and Therapy” In this study, patients with alopecia areata who experienced sustained hair regrowth while being treated with baricitinib showed improvements in health-related quality of life and reductions in anxiety and depression symptoms over 104 weeks, according to the BRAVE-AA phase III trials.
April 2024 in “JMIR infodemiology” This study found that TikTok provides valuable insights into experiences with lupus erythematosus, highlighting distress from symptoms, negative perceptions of pharmacologic treatments, and issues with feeling "medically gaslighted.
In this retrospective study of alopecia areata patients across several European countries, researchers observed a notable reduction in SALT scores, but few patients reached or maintained a clinically significant SALT score of ≤20, indicating potentially limited effectiveness of current treatments for extensive hair loss.
This review article highlights the potential of various herbal treatments, such as Saw Palmetto and Ginseng, in promoting hair growth and managing alopecia, while emphasizing the necessity for more rigorous clinical trials.
March 2024 in “Clinical, cosmetic and investigational dermatology” This study found that severe alopecia areata significantly impacts quality of life, mental health, and daily activities, particularly among women and those with a longer disease duration.
March 2024 in “Clinical, cosmetic and investigational dermatology” This study reported that five patients with alopecia areata achieved satisfactory results using 15 mg of Upadacitinib daily after conventional treatments had failed, without experiencing adverse events.
February 2024 in “International neuropsychiatric disease journal” In this abstract, the authors provide an overview of the psychological impact of alopecia areata, highlighting how this autoimmune disorder can lead to reduced quality of life, increased anxiety and depression symptoms, and decreased work productivity due to hair loss and its social implications.
February 2024 in “Scientific reports” This study identified four ferroptosis-related genes, SLC40A1, LCN2, CREB5, and SLC7A11, as potential diagnostic markers for alopecia areata, revealing reduced expression in affected patients compared to controls, with a predictive model showing high accuracy in differentiating the condition.
This study examined the molecular communication in psoriasis cells, highlighting unique immune cell interactions and identifying new features of the hair follicle cell-psoriasis axis. It suggests the potential for targeted therapies at the single-cell level to improve psoriasis treatment.
January 2024 in “Annals of Dermatology” This study found that alopecia areata patients consider more than 20% scalp hair loss, chronic duration, and involvement of additional body hair as indicators of severe disease impacting quality of life.
December 2023 in “Research in pharmacy” This review underscores the importance of phytotherapeutic compounds and adjuncts in managing polycystic ovarian syndrome but does not present new clinical evidence.
December 2023 in “Malahayati International Journal of Nursing and Health Science” In this study, researchers at the "Estella" Children's Cancer Center observed that 80.5% of children experience hair loss, and most parents reported nausea, vomiting, and mood swings as the most disruptive effects of chemotherapy during pediatric cancer treatment.
December 2023 in “Journal of health and rehabilitation research” In this study conducted at a tertiary care hospital in Karachi, oral Apremilast significantly reduced the severity of alopecia areata, shown by a notable decrease in SALT Scores over 12 weeks, suggesting it may be an effective alternative treatment option for this condition.
December 2023 in “EPRA international journal of multidisciplinary research” In this review, researchers examined current knowledge on alopecia areata, finding it affects approximately 2% of individuals, with a likely autoimmune and genetic basis, and highlighting its association with other medical and psychiatric conditions, although no cure currently exists.
This paper explores the diverse patterns and social significance of Black hair, approaching it as an art form, mathematical pattern, and ethnomathematic entity, and seeks to dispel myths while highlighting its vast possibilities.
This study found that expressions of TLR-3, TLR-7, TLR-8, and TLR-9 were significantly higher in alopecia areata patients compared to healthy controls, indicating a potential role in disease autoimmunity.
This study introduces Kalya Research, an AI-driven tool designed to identify and categorize literature on complementary and alternative medicines, showing its effectiveness compared to Medline in finding relevant alopecia research within the context of breast cancer patients.
November 2023 in “Linköping University medical dissertations” This research presents a comprehensive workflow for producing EMA-compliant autologous keratinocyte-based therapies for wound healing and explores miRNA-mediated regulations in human keratinocytes and adipose-derived mesenchymal stem cells.