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The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Hair loss in androgenetic alopecia is caused by genetic factors and androgen excess, and can be treated with combined therapies.

The androgen receptor is a promising target for breast cancer treatment, especially in triple-negative cases, but more research is needed for personalized therapies.

Higher DHT in male baldness may protect against prostate cancer.

Caffeine improves hair growth, thickness, and reduces shedding.

Formyl-peptide receptor agonists could be new anti-inflammatory drugs.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Beta-sitosterol has potential health benefits but needs more research to fully understand its effects and improve its use in treatments.

New LPA receptors (LPA4, LPA5, LPA6) have diverse roles in the body.

Minoxidil breakdown varies by enzymes, affecting hair loss treatment effectiveness.

Hormones and their receptors, especially androgens, play a key role in hair growth and disorders like baldness.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

Apremilast was not effective in treating moderate-to-severe alopecia areata.

Quercetin may help with PCOS symptoms, but more research is needed.

Female donor to male recipient sex mismatch and positive ACA-IgG are key risk factors for vitiligo and alopecia areata in chronic GvHD patients.

Sex hormones affect hair and feather growth and may help manage alopecia and hormone-dependent cancers.

Treatment can improve survival and symptoms in dogs with Cushing's disease, but outcomes are unpredictable.

High levels of male hormones in pregnant mice cause heart enlargement and poor heart function in their female babies.

Women experience various skin issues at different life stages, requiring careful treatment and awareness.

Biologic treatments for Crohn's disease and ulcerative colitis can cause skin problems, and doctors should adjust treatment if these occur.

ECM-inspired wound dressings can help heal chronic wounds by controlling macrophage activity.

Found 32 genes linked to male baldness, affecting hair growth and stress-related pathways.

Chicken feather gene mutation helps understand human hair disorders.

The document explains how to create detailed biological pathways using genomic data and tools, with examples of hair and breast development.

Melatonin receptors, found in many body parts, can help treat various diseases like depression and diabetes due to their effects on inflammation, tumor progression, sleep disorders, and body mass regulation.

Eosinophilia-myalgia syndrome, linked to contaminated L-tryptophan supplements, caused severe symptoms and some deaths, with long-term effects in survivors.

ceRNA networks offer potential treatments for skin aging and wound healing.

Researchers created a model to understand heart aging, highlighting the role of microRNAs and identifying key genes and pathways involved.

Use minoxidil or finasteride first, then try HairMax LaserComb if needed.

The health of the gut may be important in developing new ways to prevent, diagnose, and treat alopecia areata.