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Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.

Effective treatments for male pattern baldness include oral finasteride and topical minoxidil, while topical minoxidil is best for female pattern baldness.

Trilostane effectively improved symptoms in dogs with a certain adrenal gland disorder.

Different types of polycystic ovary syndrome (PCOS) have varying severity, with Type I being the most severe and common.

Lupus affects the body and skin, causing joint pain and skin issues that can be treated with steroids and antimalarial drugs.

Generalized pustular psoriasis patients often need strong medication and careful treatment due to flare-ups and complications.

Facial feminization surgery is effective in helping transgender women appear more feminine and has high patient satisfaction.

Obesity worsens PCOS symptoms, and PCOS may lead to more weight gain; managing both requires a holistic approach that includes mental health.

Isotretinoin effectively treats severe acne and similar conditions, but has common, mostly reversible side effects, requiring careful patient monitoring.

The BASP classification is a detailed and accurate way to categorize hair loss in both men and women.

Adult female acne treatment should be personalized, considering individual preferences and pregnancy, using various topical and oral medications while managing side effects and resistance.

TSH is usually the only test needed to check thyroid function in primary care.

Children with atopic dermatitis often have sleep problems, affecting their growth and behavior.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

New topical antifungals and delivery systems are improving treatment for fungal skin infections, but patient education and prevention are key.

The paper concludes that the 1982 criteria for diagnosing systemic lupus erythematosus need updating to improve accuracy and involve dermatologists in the process.

Olive oil compounds may help prevent cancer in animals, but human results are mixed.

DHT may increase the risk of heart disease and death in elderly men.

Treating psoriasis on the scalp, nails, and skin folds is challenging, often requiring systemic treatments for severe cases, with some success in topical and biologic treatments.

Nutraceuticals may improve skin health and protect against aging, but more research is needed on their optimal use and possible health risks.

Microneedling is a safe and effective treatment for various skin conditions, often preferred for its fewer side effects and shorter recovery time.

Obesity increases the risk of developing polycystic ovary syndrome, and weight loss can improve the condition.

Men over 66 taking medication for prostate enlargement have a higher risk of depression and self-harm, especially in the first 18 months of treatment.

Using human fat tissue derived stem cells in micrografts can safely and effectively increase hair density in people with hair loss.

Mutant mice help researchers understand hair growth and related genetic factors.

PCOS starts in adolescence with hormonal issues, leading to adult health problems, and early treatment is crucial.

Vitiligo affects overall health and self-esteem, needing more research and awareness.

Researchers created a fully functional, bioengineered skin system with hair from stem cells that successfully integrated when transplanted into mice.

The document concludes that proper diagnosis and FDA-approved treatments for different types of hair loss exist, but treatments for severe cases often fail and future improvements may focus on hair follicle stem cells.

Hormones, especially androgens, play a key role in acne, which can be a symptom of systemic diseases like PCOS and may require targeted treatment.