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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Finasteride effectively treats BPH, but needs more trials to understand potential.

Scientists have found a way to create hair follicles from skin cells of newborn mice, which can grow and cycle naturally when injected into adult mouse skin.

Sebocytes play a key role in controlling androgen levels in human skin.

Hair and wool have complex microscopic structures with microfibrils and varying cystine content.

The document concludes that developing generic topical drugs requires ensuring they match the original in quality, composition, and structure, and often involves complex testing and regulatory steps.

HairMax LaserComb® effectively promotes hair growth and stops hair loss in males with androgenetic alopecia, with no serious side effects.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Laser hair removal effectiveness depends on targeting hair structures without harming the skin, and improvements require more research and expert collaboration.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.

Transplant success has improved with better immunosuppressive drugs and donor matching.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

Skin grafts on mice can cause an immune response leading to hair loss, useful for studying human hair loss conditions.

Surgeons must understand the full care process for gender confirmation surgery to help transgender individuals effectively.

Formyl-peptide receptor agonists could be new anti-inflammatory drugs.

Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.

Hormones significantly affect hair and oil gland function in the skin, and more research is needed on skin-related hormone disorders.

The document concludes that accurate diagnosis and personalized treatment are important for skin problems in women with PCOS.

Ginseng is possibly safe but its effectiveness is unclear due to poor quality studies and mixed results.

Melanocytes are crucial for skin pigmentation and can affect conditions like melanoma, vitiligo, and albinism, as well as hair color and hearing.

Newborn mouse skin cells can grow hair and this process can be recreated in adult cells to potentially help with hair loss.

Skin fat helps with body temperature control and has other active roles in health.

The circadian clock is crucial for tissue renewal and regeneration, affecting stem cell functions and having implications for health and disease.

Layer-by-Layer self-assembly is promising for biomedical uses like tissue engineering and cell therapy, but challenges remain in material safety and process optimization.

Human beard hair medulla contains a unique and complex mix of keratins not found in other human tissues.

Keratin 15 is not a reliable sole marker for identifying epidermal stem cells because it's found in various cell types.

The document concludes that cosmetic surgery is still mainly a practice for women and the gender gap in this field is expected to continue.

Hair follicle regeneration needs special conditions and young cells.