14 citations
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April 2016 in “British Journal of Dermatology” This study found that a combined pattern of repigmentation was most commonly observed in vitiligo, with a new 'medium spotted' pattern proposed for areas with few hair follicles.
6 citations
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October 2006 Understanding repigmentation mechanisms in vitiligo can improve treatments and patient outcomes.
15 citations
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January 2013 in “Dermatologic Surgery” This study observed that white hair follicles in vitiligo patients may repigment following epithelial grafting and phototherapy, suggesting potential cosmetic improvements in vitiligo treatment.
6 citations
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January 2018 in “International Journal of Dermatology” This study observed that different vitiligo lesions display varying repigmentation patterns, which are associated with the extent of depigmentation, sun exposure, lesion stage, and type of therapy used.
157 citations
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December 2015 in “Journal of the American Academy of Dermatology” This case study reported significant but temporary hair regrowth and skin repigmentation in a patient with vitiligo and alopecia areata during treatment with oral ruxolitinib.
60 citations
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April 2006 in “International Journal of Dermatology” This review discusses various surgical techniques for vitiligo repigmentation, noting that suction blister and split-thickness skin grafting have the highest success rates according to previous analysis, but reports no new results.
1 citations
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January 2023 in “Research Square (Research Square)” In this report, a 61-year-old woman with vitiligo showed significant improvement after tofacitinib treatment but developed lung adenocarcinoma, highlighting potential cancer risks associated with JAK inhibitors.
24 citations
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September 2008 in “Clinical and experimental dermatology” Repigmentation in vitiligo may come from melanocyte stem cells in the skin.
August 2026 in “Journal of Personalized Medicine” This narrative review proposes the concept of "repigmentation competence" for vitiligo lesions, suggesting that therapy responses are influenced by lesion-specific biological factors related to immune, regenerative, regulatory, and microenvironmental processes, and highlights the emerging role of combination therapies targeting these pathways.
5 citations
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January 2016 in “European Journal of Dermatology” Suplatast tosilate successfully treated a woman's systemic sclerosis symptoms.
1 citations
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August 2018 in “Dermatologic Surgery” This overview describes the Dermatologic Surgery journal's comprehensive coverage of dermatologic surgery, including cosmetic and reconstructive procedures, but it presents no new research findings.
December 2018 in “European Journal of Pediatric Dermatology/PD. European journal of pediatric dermatology” This article discusses the potential involvement of hair follicle melanocytes in follicular vitiligo, noting a pattern of depigmentation centered on follicles and supported by inflammatory infiltrates, without reporting new clinical results.
January 2024 in “Dermatologic therapy” This study reported that fire needle therapy improved skin lesions, increased melanocyte numbers, and boosted melanin levels in a vitiligo mouse model by upregulating the Wnt/β-catenin signalling pathway, suggesting its potential role in treating vitiligo through promoting pigmentation.
10 citations
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July 2021 in “Clinical Cosmetic and Investigational Dermatology” This study found that combining weekly transverse needling sessions with mini-punch grafting significantly accelerated and enhanced repigmentation in stable, resistant non-segmental vitiligo lesions compared to each procedure alone or non-procedural treatment.
This review discusses various techniques for depigmentation in vitiligo patients and suggests that cryotherapy, performed by an experienced professional, may be the most cost-effective and accessible method.
11 citations
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September 2024 in “Journal of the European Academy of Dermatology and Venereology” This review explores the shared pathogenesis of alopecia areata and vitiligo and compares treatment responses, noting that hair regrowth in alopecia areata occurs more rapidly than skin re-pigmentation in vitiligo, possibly due to differences in stem cell biology and treatment effects on melanocytes.
39 citations
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March 2017 in “Dermatologic clinics” This article reviews the process of repigmentation in vitiligo and emphasizes the role of UV light as the most potent stimulus, with no new clinical findings reported.
21 citations
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January 2019 in “Experimental dermatology” This review explores how low-energy He-Ne laser therapy may stimulate repigmentation in vitiligo by affecting mitochondrial pathways and melanocyte function, but does not report new clinical results.
November 2025 in “Journal of Investigative Dermatology” Combining MMP-9 and JAK inhibitors can effectively prevent skin depigmentation in vitiligo.
1 citations
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May 2021 in “Research Square (Research Square)” This study concluded that controlled micro-injury induces hair regeneration and vitiligo repigmentation in mice, potentially through the Wnt/β-catenin pathway.
This study demonstrates that a novel autologous hair follicle-derived epithelial sheet can effectively repigment skin in patients with stable vitiligo, offering a potential new treatment option.
69 citations
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April 1998 in “Journal of The American Academy of Dermatology” In this study, single hair grafting was reported to be an effective treatment for localized/segmental vitiligo, notably in hairy skin areas, with repigmentation observed in 82% of those cases.
October 2019 in “Journal of Pakistan Association of Dermatologists” In this study, NB-UVB therapy significantly increased Wnt1 and β-catenin expression in hair follicles, which may play a role in vitiligo perifollicular repigmentation.
9 citations
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January 2013 in “Journal of Cutaneous and Aesthetic Surgery” This case report observed complete repigmentation of a stable vitiligo patch with body hair transplantation in a 28-year-old man, with no recurrence after 3 months.
5 citations
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July 2019 in “Clinical and experimental dermatology” This study found that incorporating collagenase type I into a noncultured hair follicle cell suspension technique improved cell yield and enhanced repigmentation in patients with stable vitiligo compared to dermabrasion alone.
3 citations
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June 2025 in “Stem Cell Research & Therapy” Hair follicle-derived melanocyte transplant could effectively treat vitiligo by restoring skin color.
June 2026 in “Journal of Investigative Dermatology” This study found that certain proteins linked to immune suppression and melanogenesis are associated with repigmentation in vitiligo patients undergoing standard treatment, suggesting these proteins and their pathways play roles distinct from merely reversing skin lesions.
August 2025 in “Indian Dermatology Online Journal” This study found that combining topical minoxidil with phototherapy significantly improved pigmentation and reduced vitiligo severity compared to placebo, as measured by VASI scores over 12 weeks, though the sample size was small and follow-up short.
August 2026 in “Journal of International Medical Research” This review examines the various causes and mechanisms of leukotrichia, noting it as a final manifestation of diverse underlying mechanisms and suggesting its relevance to diagnosis and treatment strategies, but it reports no new experimental findings.
In this study involving 13 patients with vitiligo-associated leukotrichia, minimal hair repigmentation was observed following treatment with fractional CO₂ laser and topical betamethasone, though the method was well tolerated, highlighting the need for further research to optimize treatment parameters.