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A very low-calorie ketogenic diet is effective for quick weight loss and improving health in obese patients, with careful management of side effects and maintenance.

Female Pattern Hair Loss affects women's self-esteem and needs more research for better treatment.

Gynecologists should provide comprehensive care for transgender patients, including mental health evaluation, hormone therapy, and surgical options, while monitoring for side effects and ensuring patient safety.

The article concludes that better understanding gene regulation related to seasonal changes can offer insights into the mechanisms of seasonal timing in mammals.

Certain types of T cells are essential for healthy skin and play a role in skin diseases, but more research is needed to improve treatments.

Advanced nanocarrier and microneedle drug delivery methods are more effective, safer, and less invasive for treating skin diseases.

Androgens cause skin issues like acne and hair growth in women, often due to PCOS, and can be treated with medication and lifestyle changes.

An imbalance between certain immune cells is linked to a chronic skin condition and may be influenced by obesity, smoking, and autoimmune issues.

Some systemic treatments work for nail psoriasis but can have serious side effects.

Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.

Ablative fractional resurfacing could improve how well topical drugs penetrate the skin, but more research is needed to fine-tune the method.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

The document concludes that Nonclassic Congenital Adrenal Hyperplasia requires personalized treatment plans to manage symptoms and fertility, with glucocorticoids being a common therapy.

Different treatments for alopecia areata have varying success rates and side effects; intralesional steroids are most effective.

Ice-skating athletes often have skin problems due to cold, infections, and inflammation, needing careful treatment and prevention.

Changes in skin microbes play a role in some skin diseases and could lead to new treatments.

The research suggests that the global distribution of PCOS is likely due to historical human migration and that genes affecting PCOS may have different impacts on males and females.

The document suggests creating a validated score to diagnose Cushing's Syndrome and considers plasma steroid profiling as a simpler diagnostic method.

Beard and scalp hair cells have different gene expressions, which may affect beard growth characteristics.

Systemic glucocorticosteroids are a primary treatment for various skin conditions but require careful management due to potential side effects and relapses.

Genetics play a role in acne, but how exactly they contribute is not fully understood.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Bariatric surgery may help severely obese teenagers but has risks and requires careful patient selection and long-term care.

Herbal nano-formulations show potential for effective skin delivery but need more research.

Cyproterone acetate treatment is safe and causes mild feminization, which increases with added estrogen.

Women with PCOS tend to have higher anxiety and depression levels compared to healthy women.

Androgen Deprivation Therapy for prostate cancer often reduces sexual function but intermittent therapy may be more tolerable.

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.

MicroRNAs are important for skin health and could be targets for new skin disorder treatments.