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Glossary vitamin A

fat-soluble nutrient crucial for vision, immunity, and skin health

Vitamin A is a fat-soluble nutrient essential for maintaining healthy vision, immune function, and skin health. It exists in two primary forms: retinoids (found in animal products) and carotenoids (found in plant-based foods). Deficiency in vitamin A can lead to vision problems, including night blindness, and can compromise the immune system.

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research Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention

271 citations , September 2008 in “Nutrition reviews”

This study identified new dietary ligands for the human vitamin D receptor, including curcumin and gamma-tocotrienol, which may influence its biological functions.

research Vitamin D and the skin: Focus on a complex relationship: A review

139 citations , February 2014 in “Journal of Advanced Research”

This review explores the impact of vitamin D deficiency on the skin from a dermatological perspective, but reports no new clinical results.

research The Role of Vitamins and Minerals in Hair Loss: A Review

134 citations , December 2018 in “Dermatology and Therapy”

This review discusses the potential role of vitamins and minerals in managing non-scarring alopecia but reports no clinical results; the authors advocate for further controlled trials to explore these relationships.

research Glandular metaplasia of hair follicles and other responses to vitamin A excess in cultures of rodent skin

77 citations , April 1968 in “Development”

This study found that excess vitamin A in organotypic cultures of embryonic mouse skin led to abnormal hair follicle development and glandular metaplasia, unlike in untreated controls that showed normal differentiation.

research Case Report Vitamin A Toxicity and Hypercalcemia

52 citations , May 1982 in “The American journal of the medical sciences”

This study found that the most likely cause of hypercalcemia in a patient with symptoms of hypervitaminosis A and a history of chronic vitamin A ingestion was vitamin A toxicity.

research Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases

47 citations , September 2023 in “Pharmacological Reports”

In this review, researchers explored the roles of vitamins A, B3, C, D, and E in skin immunity, highlighting their potential as therapeutics for skin diseases due to their antioxidant, anti-inflammatory, and antimicrobial properties.

Atrophic Telogen Effluvium from Cytotoxic Drugs and a Randomized Controlled Trial to Investigate the Possible Protective Effect of Pretreatment with a Topical Vitamin D3 Analogue in Humans

research 'Atrophic telogen effluvium' from cytotoxic drugs and a randomized controlled trial to investigate the possible protective effect of pretreatment with a topical vitamin D3 analogue in humans

47 citations , July 2005 in “British Journal of Dermatology”

This study found no protective effect of topical calcipotriol on hair loss in chemotherapy patients, and the authors propose the term "atrophic telogen effluvium" for this type of hair loss.

research Penetration and Local Effect of Vitamin A on the Skin of the Guinea Pig.,

45 citations , August 1954 in “Experimental Biology and Medicine”

This study found that vitamin A dissolved in alcohol penetrates skin quickly and does not impair hair growth, even in large doses, but it does not retard keratinization unlike when dissolved in fatty acids.

research The use of a retinoid receptor antagonist in a new model to study vitamin A-dependent developmental events.

44 citations , May 1998 in “PubMed”

In this study, a specific retinoic acid receptor antagonist caused severe craniofacial anomalies in mouse fetuses when administered early in pregnancy, but not limb anomalies, highlighting developmental stage-specific roles of retinoic acid.

research Safety of High-Dose Vitamin A

39 citations , June 2009 in “Oncology”

This study observed that high-dose retinol palmitate was well-tolerated in resected stage I lung cancer patients, though it raised concerns about potential impacts on lipid metabolism due to elevated gamma-GT levels and triglycerides.

research Vitamin A toxicity: When one a day doesn't keep the doctor away

32 citations , January 2006 in “Liver transplantation”

This case report describes a 60-year-old male with vitamin A toxicity leading to severe liver disease and symptoms that resolved following liver transplantation, suggesting transplantation as a treatment option for noncirrhotic portal hypertension when symptoms do not improve after stopping vitamin A.

research Combined effect of high-dose vitamin A, vitamin E supplementation, and zinc on adult patients with diabetes: A randomized trial

20 citations , June 2020 in “Journal of Advanced Research”

This study found that high-dose vitamin A and E supplementation with zinc may improve glycemic control and beta-cell function in patients with type 2 diabetes, compared to no supplements.

research Histochemical evidence of mucosubstances in the metaplastic epidermis and hair follicles produced in vitro in the presence of excess vitamin A

20 citations , February 1977 in “The anatomical record”

This study found that excess vitamin A in organ cultures of mouse embryos led to significant changes in epidermis and hair follicles, altering morphogenesis and polysaccharide distribution.

research Dietary vitamin A regulates wingless-related MMTV integration site signaling to alter the hair cycle

18 citations , October 2014 in “Experimental Biology and Medicine”

This study found that feeding mice high levels of dietary vitamin A increased WNT signaling, which activated hair follicle stem cells and may have accelerated alopecia areata progression.

research The Stability of Vitamin A-induced Metaplasia of Mouse Vibrissa Follicles In Vitro

18 citations , October 1978 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that excess vitamin A induced stable glandular morphogenesis and mucous metaplasia in embryonic mouse vibrissa follicles, even after switching to standard medium.

research Skin Hyperpigmentation and Increased Angiogenesis Secondary to Vitamin B12 Deficiency in a Young Vegetarian Woman

16 citations , January 2008 in “Acta dermato-venereologica”

Vitamin B12 deficiency can cause skin darkening and increased blood vessels, but treatment can improve symptoms.

research Oral vitamin A as an adjunct treatment for canine sebaceous adenitis

15 citations , May 2011 in “Veterinary Dermatology”

In this study, dogs with sebaceous adenitis were treated with oral vitamin A, but responses varied widely, showing improvements in some cases while others experienced no benefit.

research Vitamin A in Skin and Hair: An Update

14 citations , July 2022 in “Nutrients”

This review discusses new research on the role of retinoids in skin and hair health and reports no clinical results.

research Role of vitamin D in hair loss: A short review

14 citations , September 2021 in “Journal of Cosmetic Dermatology”

This review discusses vitamin D's role in hair follicle biology and its association with hair loss but reports no conclusive evidence for its effectiveness as a treatment, indicating the need for further studies.

research Vitamin D and the Skin: A Review for Dermatologists

13 citations , April 2019 in “Actas Dermo-Sifiliográficas”

This review discusses the relationship between vitamin D and various skin diseases, highlighting recent findings on its role and the importance of assessing and correcting vitamin D levels, but reports no new clinical results.

research Vitamin A alleviates heat stress‐induced damage to hair follicle development in Rex rabbits

12 citations , October 2021 in “Journal of the Science of Food and Agriculture”

This study found that adding vitamin A to the diet improved hair follicle density and fur quality in heat-stressed Rex rabbits, involving specific signaling pathways.

research Vitamin B₃ (niacin), B₆, C, and iron intake are associated with the free androgen index, especially in normoandrogenic polycystic ovary syndrome

10 citations , July 2022 in “Journal of the Turkish-German Gynecological Association”

In this study, micronutrient intake was associated with androgen levels in women with PCOS, with the association more pronounced in NA PCOS compared to HA PCOS groups.

research Conversion of Carotene to Vitamin A by Sebaceous Glands

9 citations , October 1957 in “A M A Archives of Dermatology”

In this study, carotene injected into the skin was converted into vitamin A by sebaceous gland cells, where it was not normally detectable.

research Use of Vitamins and Minerals in the Treatment of Hair Loss: A Cross-Sectional Survey among Dermatologists in Saudi Arabia

9 citations , November 2014 in “Journal of Cutaneous Medicine and Surgery”

This study found that a majority of dermatologists in Saudi Arabia believe in using vitamins and minerals to treat hair loss but emphasized the need for more research to confirm their effectiveness.

research Vitamins A, B, C, and D: A Short Review for the Dermatologist.

7 citations , July 2021 in “PubMed”

This review assesses the role of vitamins A, B, C, and D in treating dermatologic conditions and highlights promising applications, although further research is required to confirm their efficacy.

research Dermatopathy in juvenile Angus cattle due to vitamin A deficiency

7 citations , May 2012 in “Journal of veterinary diagnostic investigation”

This study reports that vitamin A deficiency can cause dermatologic issues like alopecia and orthokeratosis in Angus calves, and affected calves improved with vitamin A supplementation.

$Dietary Vitamin A Impacts Refractory Telogen$

research Treatment of alopecia totalis/universalis/focalis with vitamin D and analogs: Three case reports and a literature review

3 citations , November 2021 in “World Journal of Clinical Pediatrics”

This study observed that vitamin D therapy may help manage alopecia areata, totalis, and universalis, with promising hair regrowth in some pediatric cases, though further trials are needed.