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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

MK-0773 safely increased muscle mass but did not improve muscle strength or function in elderly women with sarcopenia.

Pregnancy can cause various skin changes and diseases, with PUPPP being the most common skin condition specific to pregnancy.

Hormone therapy for trans individuals is effective and generally safe in the short term.

Most women with excess hair growth have an underlying hormonal issue, often treated with medication and hair removal methods.

Male hormones, particularly DHT, are linked to male pattern hair loss, and treatments like finasteride can help, but they don't work for postmenopausal women's hair loss, which may have different causes.

Pregnancy can cause skin darkening, varicose veins, more sweating, hair growth, hair loss after birth, nail changes, and gum inflammation.

Most women with PCOS have high levels of male hormones, and free testosterone is the best marker for this.

Adult female acne treatment should be personalized, considering individual preferences and pregnancy, using various topical and oral medications while managing side effects and resistance.

Inhibiting 5α-reductase can help reduce prostate cancer risk and improve treatment.

Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.

The document concludes that certain genetic mutations and dietary factors are involved in acne development, and treatments like isotretinoin and diet changes can help manage it.

Hormonal treatments, including birth control and antiandrogens, can effectively treat acne in women.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Lower SHBG levels may increase the risk of PCOS.

Skin changes can help diagnose and manage endocrine disorders like thyroid problems, diabetes, and adrenal gland conditions.

Gynecologists should provide comprehensive care for transgender patients, including mental health evaluation, hormone therapy, and surgical options, while monitoring for side effects and ensuring patient safety.

FPHL is a common, age-related, genetic hair loss with unclear causes and limited treatment options.

Hormones, especially androgens, play a key role in acne, which can be a symptom of systemic diseases like PCOS and may require targeted treatment.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Insulin resistance may contribute to various skin diseases and treating it could improve skin health and prevent more serious conditions.

Acne is a chronic disease linked to various systemic conditions and has significant psychological and social effects.

The document explains how the male reproductive system works, its role in making testosterone, and how conditions like obesity can disrupt it, leading to low testosterone and fertility issues.

New genes and pathways are important for testosterone production and male sexual development.

Hormones and genetics affect hair growth and patterns, with some changes reversible and others not.

Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.

Athletes use steroids to enhance performance despite health risks and legal issues, and education on their dangers is needed.

Non-binary transgender individuals need personalized hormonal treatments for better well-being and quality of life.

Women with PCOS often have hair loss, which is linked to acne or excess body hair but not to worse hormone or metabolic issues.

Skin problems are common and important signs of eating disorders and treating the eating disorder can improve these skin conditions.