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Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

Terazosin and finasteride effectively treat BPH, but combining them adds no extra benefit.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Fat-related cells are important for initiating hair growth.

Improving artificial vascular grafts requires better materials and surface designs to reduce blood clotting and support blood vessel cell growth.

Corticosteroids, especially prednisone, improve short-term muscle strength in Duchenne muscular dystrophy but have manageable side effects.

Stress can worsen skin and hair conditions by affecting the skin's immune response and hormone levels.

Human skin can make serotonin and melatonin, which help protect and maintain it.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

The conclusion is that certain cell interactions and signals are crucial for hair growth and regeneration.

The document concludes that mouse models are helpful but have limitations for skin wound healing research, and suggests using larger animals and genetically modified mice for better human application.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

Niosomes are a promising, stable, and cost-effective drug delivery system with potential for improved targeting and safety.

The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Melatonin is important for skin health and protection, and can be made by the skin or applied to it.

Chemotherapy causes hair loss by damaging hair follicles and stem cells, with more research needed for prevention and treatment.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Lactate production is important for activating hair growth stem cells.

Artificial skin development has challenges, but new materials and understanding cell behavior could improve tissue repair. Also, certain growth factors and hydrogel technology show promise for advanced skin replacement therapies.

Lifestyle changes can improve body composition, excess male hormone levels, and insulin resistance in women with PCOS.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

HairMax LaserComb® effectively promotes hair growth and stops hair loss in males with androgenetic alopecia, with no serious side effects.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Liposomal systems show promise for delivering drugs through the skin but face challenges like high costs and stability issues.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Researchers developed promising agents for prostate cancer imaging, with the best one showing high potential for clinical use.