745 citations
,
February 1992 in “Trends in genetics” This article describes the potential role of various growth factors and molecules in regulating mammalian hair follicle development but does not present new experimental results.
178 citations
,
June 1994 in “Journal of Investigative Dermatology” This study found that a non-scarring alopecia in C3H/HeJ mice resembles human alopecia areata and may serve as a valuable model for studying specific subtypes of the human condition.
173 citations
,
July 1995 in “Biochemical and biophysical research communications” This study suggests that IGF-I may mediate androgen-induced hair growth in outer root sheath cells cocultured with beard dermal papilla cells.
161 citations
,
June 1994 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that the switch-off of melanogenesis during the hair cycle in C57 BL-6 mice is a gradual and stochastic process starting in mid anagen VI, with specific biochemical markers indicating the transition to catagen.
138 citations
,
November 1977 in “Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics” 98 citations
,
November 2017 in “Elsevier eBooks” This chapter reviews the male accessory sex glands in rats and their responses to hormonal influences, detailing common spontaneous changes and effects of compounds, but it provides no new experimental findings.
81 citations
,
January 2003 in “Journal of cosmetic and laser therapy” This review discusses various techniques for treating post-acne scars, highlighting new laser technologies and tissue augmentation methods, but reports no new clinical results.
79 citations
,
January 1975 in “Food and Cosmetics Toxicology” In this study, oxidation hair dye formulations tested on mice showed no evidence of causing systemic toxicity or cancer over an 18-month period.
66 citations
,
January 1987 in “Journal of Investigative Dermatology” This study found that enzyme activity critical to cancer induction by polycyclic aromatic hydrocarbons in human hair follicles increased after using a crude coal tar-containing shampoo for four days and was substantially inhibited by imidazole compounds.
61 citations
,
January 1970 in “Toxicology and Applied Pharmacology” 59 citations
,
January 1976 in “Vitamins and hormones” This chapter discusses androgen receptors and protein synthesis in the prostate, reporting that DHT-dependent receptor protein translocation increases protein-synthesizing activity after androgen injection in rat models.
49 citations
,
January 1991 in “Food and chemical toxicology” In this study, zinc chloride was found to be severely irritant to the skin in rabbit, guinea-pig, and mouse models, while zinc oxide, zinc sulphate, zinc pyrithione, and zinc undecylenate showed minimal to no irritancy.
44 citations
,
November 2007 in “Journal of toxicology and environmental health. Part B, Critical reviews” This review explores how copper and zinc concentrations in hair may serve as bioindicators and discusses their potential associations with health disorders, but it reports no new clinical findings.
40 citations
,
September 2014 in “Journal of cosmetic and laser therapy” This case series found that combining ablative fractional resurfacing and acoustic pressure ultrasound with triamcinolone treatment led to complete recovery in patients with areata alopecia.
39 citations
,
July 2005 in “Current medical research and opinion” This article discusses available methods for managing excessive facial hair growth in women and mentions that eflornithine 11.5% cream can reduce hair growth and the frequency of removal, but it reports no new clinical findings.
36 citations
,
June 2016 in “Journal of dermatological treatment” This study found that a combination of low-fluence Q-switched 1064 nm Nd:YAG laser, hydroquinone cream, and oral tranexamic acid showed promising results for Riehl’s melanosis in Asian patients, with no serious adverse events reported.
34 citations
,
October 1975 in “Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis” 34 citations
,
July 1958 in “Biochimica et Biophysica Acta” 31 citations
,
October 1971 in “Steroids” This study found that human beard hair follicles metabolize dehydroepiandrosterone into various compounds at significantly higher rates than those reported for human skin, suggesting unique metabolic processes in hair follicles.
29 citations
,
November 1975 in “Clinics in endocrinology and metabolism” This article discusses the synthesis and action of testosterone and its interaction with specific receptors, reporting no new research findings.
28 citations
,
September 2016 in “Future oncology” In this study, a UK expert panel discussed strategies for managing common side effects of vismodegib, a hedgehog pathway inhibitor used for advanced basal cell carcinoma, concluding that adverse events like taste disturbances and muscle cramps can be effectively managed to optimize treatment duration.
27 citations
,
September 2015 in “Drug development and industrial pharmacy” This study demonstrated that adapalene encapsulated in liposomes significantly improved drug delivery to hair follicles compared to gel and drug solution, potentially targeting acne treatment more effectively.
27 citations
,
September 1994 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that relatively low concentrations of 1,25(OH)2D3 stimulated human hair follicle and fiber growth, while higher concentrations inhibited growth in a whole-organ culture system.
27 citations
,
April 1971 in “Surgical Clinics of North America” The punch graft technique effectively redistributes hair to cover bald areas.
26 citations
,
January 1964 in “Experimental Cell Research” 25 citations
,
January 1958 in “Elsevier eBooks” 18 citations
,
April 1989 in “Clinics in Dermatology” This study found that using an argon gas-based system for intralesional cryotherapy significantly reduced keloid scar volume, improved scar quality, and resulted in low recurrence rates after 12 months.
13 citations
,
January 2010 in “Immunopharmacology and immunotoxicology” This study found that increased Bcl-2 protein expression after DPCP treatment was associated with hair regrowth in alopecia areata patients, suggesting its role in inhibiting apoptosis.
13 citations
,
March 1997 in “Research in Veterinary Science/Research in veterinary science” This study found that epithelial keratin K 6 is associated with hyperkeratotic and ulcerated changes in the gastric pars oesophagea of pigs, suggesting epithelial proliferation plays a role in ulcer development.
12 citations
,
January 2006 in “Journal of Dermatological Treatment” This open-pilot study found that topical 1% sildenafil did not show significant hair growth in children with alopecia areata, as outcomes seemed due to spontaneous disease regression.