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Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.

Long-term finasteride use doesn't change bone density or metabolism.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Testosterone therapy increases bone density in older men with low testosterone levels.

Cushing's syndrome can cause serious health problems, and early treatment is crucial, but some issues may remain after treatment.

Early development of hair, teeth, and glands involves specific signaling pathways and cellular interactions.

The document concludes that certain genetic mutations and dietary factors are involved in acne development, and treatments like isotretinoin and diet changes can help manage it.

Genetic discoveries are key for understanding, diagnosing, and treating inherited hair and nail disorders.

Women with hyperandrogenic amenorrhea have similar bone density to healthy women but lower than androgenized women without amenorrhea, and high DHEAS levels might affect bone density.

Researchers identified specific genes that are important for mouse skin cell development and healing.

Cantú syndrome may be linked to pituitary adenomas.

The document describes various skin conditions, their features, and treatments but lacks detailed study size information.

Newly divided skin cells quickly move to join skin structures due to tissue tension and specific signals.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

Certain proteins, Lgr5 and Lgr6, are important markers of adult stem cells and are involved in tissue repair and cancer development.

The NAMS 2014 recommendations guide healthcare providers on treating health issues in midlife women, emphasizing individualized care and informed decision-making.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.

Women with PCOS have overall higher body fat, not abnormal fat placement, and more insulin resistance.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

K_ATP channel gene mutations are linked to heart diseases, but more research is needed to understand the connection and treatment potential.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.

Estrogens and SERMs can help with skin aging, but their safety and effectiveness need more research.

The conclusion is that acne, alopecia, and hyperhidrosis are common skin issues with various treatments available, and accurate diagnosis is key for effective management.

Wounds on the face usually heal with scars, but understanding how some wounds heal without scars could lead to better treatments.

Plant steroid hormones show growth, health, and medicinal benefits in various organisms, including potential for treating diseases.

The document suggests creating a validated score to diagnose Cushing's Syndrome and considers plasma steroid profiling as a simpler diagnostic method.