March 2023 in “International Journal of Molecular Sciences” This study found that exosomes from adipose mesenchymal stromal cells, particularly those carrying miR-122-5p, may enhance hair follicle regeneration in androgenic alopecia by targeting the TGF-β/SMAD3 axis.
10 citations
,
January 2012 in “Journal of Oncology” This paper explores the relationship between the dermal extracellular matrix and cutaneous malignant melanoma, suggesting that ECM involvement may play a key role in the cancer's growth, invasiveness, and initial metastasis.
8 citations
,
January 2013 in “BioMed Research International” This study observed that both Factor XIIIa+ dermal dendrocytes and microvasculature size decreased with scalp aging and that alopecia changes resembled stress-induced premature senescence.
8 citations
,
January 2011 in “Experimental and Therapeutic Medicine” This review summarizes the characteristics of the peri-malignant melanoma stroma, indicating its potential role in early dermal metastatic migration and increased metastasis risk.
This study found that γδ T cells play a role in regulating stromal behavior, influencing the composition and vascularity of fibrotic tissues during the foreign body response.
26 citations
,
July 2021 in “Frontiers in Cell and Developmental Biology” This review discusses mesenchymal stromal cell-conditioned medium for various skin conditions and found improvements in wound healing, hair restoration, and more, but emphasizes the need for further research to validate these findings.
2 citations
,
January 2019 in “Biomecánica” This review examines the roles of Hyaluronic Acid and Versican in the skin extracellular matrix and reports no new research findings, highlighting their involvement in processes like differentiation and wound healing.
13 citations
,
September 2017 in “Cytometry Part A” This study explored the dermal stem cell niche of equine hair follicles, revealing typical fibroblast morphology and confirming the expression of standard stem cell markers comparable to other species.
18 citations
,
July 2012 in “Cell Biology International Reports” This study suggests that human mesenchymal stem cells have the potential to differentiate into dermal papilla cells both in vitro and in vivo.
April 2021 in “Journal of Investigative Dermatology” This study suggests that edelweiss extract may promote hair growth and reduce shedding in ex vivo experiments by affecting hair follicle anagen phase duration and keratinocyte proliferation.
5 citations
,
October 2021 in “PubMed” This study found that exosomes derived from human adipose stem cells significantly enhanced the proliferation and migration of dermal papilla cells compared to those from platelet-rich plasma, suggesting potential benefits for hair loss treatment.
October 2025 in “Cell Transplantation” This review discusses recent advancements in hair loss treatments, including stem cell and hair follicle cell therapies, growth factors, extracellular vesicles, gene therapy, and tissue engineering, highlighting their potential in improving hair regeneration and follicle health.
3 citations
,
September 2019 in “Clinical and experimental dermatology” This study found that basal cell carcinoma cells differentiate along hair follicle lineages and may be influenced by hair follicle cycle modulators for potential therapeutic targeting.
1 citations
,
July 2024 in “International Journal of Molecular Sciences” In this study, miR-181a was found to inhibit the proliferation and induction abilities of ovine dermal papilla cells by targeting the GNAI2 gene and affecting the Wnt/β-Catenin signaling pathway, highlighting its role in the regulation of hair follicle growth and development.
9 citations
,
June 2020 in “Tissue Engineering and Regenerative Medicine” This study found that applying HHORSC exosomes may enhance the hair inductivity of dermal papilla cells, potentially improving treatments for hair loss.
September 2022 in “Institutional Repositories DataBase (IRDB)” Adipose-derived stem cells can be transformed into hair-forming cells using specific extracellular vesicles, offering potential for hair regeneration therapies.
113 citations
,
November 2017 in “Scientific Reports” This study found that treatment with mesenchymal stem cell extracellular vesicles enhanced hair growth in mice and stimulated dermal papilla cell activity and growth factor production in vitro.
April 2025 in “Cellular and Molecular Biology” This study found that human dermal stem/progenitor cells demonstrated greater proliferation and differentiation potential than hair follicle dermal papilla cells, which showed increased expression of hair regeneration markers.
September 2017 in “Journal of Investigative Dermatology” This study found that dermal papilla cells exhibit stage-dependent variation in histone methylation during the hair follicle cycle and display distinct chromatin marker expression when transitioning to in vitro culture.
232 citations
,
October 2015 in “International journal of molecular sciences” This review discusses the role of epidermal and other adult stem cells in skin repair, focusing on their potential therapeutic applications for non-healing wounds and other skin disorders, but reports no new research results.
41 citations
,
September 2010 in “Journal of dermatological science” This study suggests that mesenchymal stem cell-induced dermal papilla-like tissues can generate new hair follicles in mice, indicating potential for developing hair cell therapy using stem cells.
41 citations
,
June 2006 in “Journal of Investigative Dermatology” This study identified three genes with significantly higher expression in androgen-sensitive beard dermal papilla cells compared to androgen-insensitive scalp cells, suggesting potential novel signaling pathways in hair follicles.
38 citations
,
June 2016 in “Nanomedicine: Nanotechnology, Biology and Medicine” In this study, the RADA-PRG hydrogel enhanced SKP proliferation, survival, and gene expression, effectively supporting hair follicle regeneration in mice.
35 citations
,
January 2014 in “Journal of Tissue Engineering” This review discusses recent advances in the role of dermal papilla cells and adipocyte lineage cells in hair regeneration, but it reports no new clinical results.
22 citations
,
August 2017 in “Stem cells and cloning” This review analyzes therapies used for androgenic alopecia, highlighting potential advances from stem cell technologies and regenerative medicine, and reports no new clinical results.
14 citations
,
July 2019 in “Experimental and Molecular Medicine” This study suggests that the secretome from amniotic fluid-derived mesenchymal stem cells overexpressing Nanog could stimulate hair growth and increase follicle density, potentially aiding in alopecia treatment.
13 citations
,
July 2022 in “Frontiers in cell and developmental biology” This review discusses the potential of cell-derived nanovesicles as innovative treatment strategies for hair growth and provides no new clinical results; the authors emphasize the need for further understanding of their mechanisms.
10 citations
,
January 2013 in “Stem Cells and Development” This study suggests that dermal stem/progenitor cells can be enriched by intracellular granularity and display high proliferation and differentiation potential in vitro, distinguishing them from other fibroblasts and progenitors.
January 2008 in “Durham e-Theses (Durham University)” This study observed that stem cells from the hair follicle dermis share similarities with bone marrow-derived mesenchymal stem cells and have potential to form neural-like cells under specific conditions.
2 citations
,
May 2017 in “InTech eBooks” This review discusses the regenerative potential of hair follicle stem cell populations and current approaches to reconstructing folliculogenesis for alopecia therapy, but reports no new clinical results.