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This study found that VEGF stimulates the proliferation of human hair follicle dermal papilla cells via the VEGFR-2/ERK pathway, without involving p38, JNK, or AKT signaling.

This study observed that VEGF165 increases proliferation and migration but alters adhesion properties of cultured human hair follicle cells, indicating a potential role for VEGF/VEGFR-2 in hair follicle regulation beyond angiogenesis.

This study found that human outer root sheath cells express VEGF receptor-2, and exogenous VEGF165 significantly stimulates their proliferation through activation of the ERK signaling pathway.

This study found that Sargassum muticum extract and apo-9′-fucoxanthinone promoted hair growth in rat and mouse models by increasing dermal papilla cell proliferation and activating certain signaling pathways.

This study generated a gene-edited cashmere goat with improved cashmere yield and fiber length by integrating VEGF at the FGF5 site, offering insights into hair growth mechanisms.

This study found that GPC1 is a crucial regulator of angiogenesis in human dermal microvascular endothelial cells, indicating its potential as a target for treating alopecia.

This study found that phosphorylated VEGFR-2 is present in human scalp epidermal appendages and suggests it plays a role in their daily regulation.

This study found that while the EtOAc fraction of Centella asiatica had the highest antioxidant activity, it was toxic to human follicle dermal papilla cells, but the EtOH crude extract promoted hair growth by enhancing VEGF expression.

This study found that a combination of vitamins in hair care products promoted hair shaft elongation in a mouse model by activating the PlGF/VEGFR-1 signaling pathway.

In this study, recombinant goat VEGF164 increased hair growth when applied to the skin of shaved mice.

This study developed a dissolvable microneedle system delivering specific molecules to remodel lymphatic networks and normalize metabolic processes, which accelerated hair growth and activated hair follicle stem cells in a mouse model of androgenetic alopecia.

This study found that VEGFR-2 activation may play a role in hair follicle differentiation, proliferation, and apoptosis by co-expressing with several key proteins in normal human scalp skin.

In this study, androgen was found to increase VEGF expression, but not VEGFR-2, in rat corpus cavernous, with DHT likely playing a key role.

In this study, oral minoxidil treatment significantly increased serum VEGF levels and improved hair growth measures compared to a control group, suggesting its potential as an effective approach for promoting hair regrowth in androgenetic alopecia.

This study found that depletion of KRT17 in endometrial cancer reduced cell growth, motility, and angiogenesis, suggesting KRT17 as a potential therapeutic target.

This study found that VEGF significantly enhances perifollicular vascularization during the hair growth phase, accelerating hair regrowth and increasing follicle and hair size, while its inhibition retards hair growth.

This review explores mechanisms of skin angiogenesis and suggests targeting blood vessels as a promising therapy for skin diseases, but it reports no new research results.

This study found that dermal papilla cells in human hair follicles exhibit stronger expression of VEGF mRNA and protein compared to other follicular cells, suggesting their key role in angiogenic processes related to hair growth.

This study demonstrates that transfected epidermal stem cells using a novel 3D transfection system significantly enhanced wound healing and may serve as an effective therapeutic agent and gene delivery method for wound treatment.

In this study, VEGF165 induced hair follicle stem cells to differentiate into vascular endothelial cells, potentially supporting angiogenesis and neovascularization, with the Notch signaling pathway affecting differentiation efficiency.

In this animal study, topical VEGF gel increased hair growth and thickness in Mesocricetus auratus, although it was not completely inert, highlighting the need for further toxicity confirmation.

This study found that the VEGF +405G/C polymorphism may be an inheritable risk factor for polycystic ovary syndrome in south Indian women.

In this study, topical tofacitinib significantly increased hair regrowth in mice compared to minoxidil or vehicle, potentially due to elevated VEGF levels and reduced inflammation.

This study suggests that type IV collagenases, MMP-2 and MMP-9, play important roles in the hair cycle by regulating the expression of VEGF, IGF-1, and TGF-β in mice.

This study found that the type IV collagenases, MMP-2 and MMP-9, play significant roles in the hair cycle, potentially through their influence on VEGF, IGF-1, and TGF-β expression.

This study found that millimolar concentrations of minoxidil in the skin induced VEGF production through HIF-1 stabilization by inhibiting PHD-2, implying a molecular mechanism for hair growth promotion.

This study concluded that using human umbilical cord blood mononuclear cells transfected with VEGF and FGF2 genes enhances skin wound healing in rats, demonstrating greater wound revascularization compared to controls.

This review examines how hormonal, vascular, and neuropeptide factors may regulate hair growth, suggesting a combined approach could contribute to developing new treatments for hair loss; it reports no new clinical results.

In this study, hydrolysates of lactic acid bacteria were found to enhance hair growth in C57BL/6 male mice more effectively than 5% minoxidil.

In this study, researchers suggest that strategic early intervention during fetal wound healing could lead to significantly improved long-term skin regeneration outcomes.