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GlossaryVoltage-Dependent Anion Channel 1 (VDAC1)

regulates ion flow in mitochondrial outer membrane

Voltage-Dependent Anion Channel 1 (VDAC1) is a protein found in the outer membrane of mitochondria, the energy-producing structures in cells. It acts as a gatekeeper, regulating the flow of ions and small molecules in and out of the mitochondria, which is crucial for cellular energy production and metabolism.

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Cyanidin 3-O-Arabinoside Suppresses DHT-Induced Dermal Papilla Cell Senescence by Modulating p38-Dependent ER-Mitochondria Contacts

research Cyanidin 3-O-Arabinoside Suppresses DHT-Induced Dermal Papilla Cell Senescence by Modulating p38-Dependent ER-Mitochondria Contacts

14 citations, March 2022 in “Journal of Biomedical Science”

Cyanidin 3-O-arabinoside may help treat a common form of hair loss by protecting cells against aging and improving cell function.

research Hunting the Hair Cycle Clock: Evidence That Mitochondrially Localized MPZL3 Is a Key Element in Murine and Human Hair Follicles

August 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

MPZL3 is important for controlling the hair growth cycle in mice and humans.

A Novel Link Between Human Hair Follicle Neuroimmunology and Mitochondrial Biology: Substance P Increases Intrafollicular Oxidative Stress and Mitochondrial Biogenesis

research A Novel Link Between Human Hair Follicle Neuroimmunology and Mitochondrial Biology: Substance P Increases Intrafollicular Oxidative Stress and Mitochondrial Biogenesis

July 2022 in “Journal of Investigative Dermatology”

Substance P may contribute to hair loss by increasing oxidative stress and mitochondrial activity in hair follicles.

research Does Mitochondrial Dysfunction Drive Immune Privilege Collapse in Lichen Planopilaris Pathogenesis?

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mitochondrial dysfunction may contribute to chronic inflammation and immune system issues in Lichen planopilaris.

research OsUEV1B, a Ubc Enzyme Variant Protein, Is Required for Phosphate Homeostasis in Rice

4 citations, February 2021 in “Plant journal”

OsUEV1B protein is essential for controlling phosphate levels in rice.

research N-Terminal Functional Domain of Gasdermin A3 Regulates Mitochondrial Homeostasis via Mitochondrial Targeting

76 citations, June 2015 in “Journal of biomedical science”

Mutations in Gasdermin A3 cause skin inflammation and hair loss by disrupting mitochondria.

research Molecular Basis of Hair Cell Loss

66 citations, February 2015 in “Cell & tissue research/Cell and tissue research”

The document concludes that there are no effective clinical treatments for hearing loss due to hair cell damage, but research is ongoing.

Expression and Roles of Steroidogenic Acute Regulatory (StAR) Protein in Non-Classical, Extra-Adrenal, and Extra-Gonadal Cells and Tissues

research Expression and Roles of Steroidogenic Acute Regulatory (StAR) Protein in Non-Classical, Extra-Adrenal, and Extra-Gonadal Cells and Tissues

48 citations, February 2013 in “Molecular and Cellular Endocrinology”

The protein StAR is found in 17 different organs and can affect hair loss and brain functions, but its full role is not yet fully understood.

research Calcium Regulation of Stem Cells

25 citations, May 2020 in “EMBO reports”

Calcium is important for stem cell function and maintenance, especially in blood and skin cells.

research The E6/E7 Oncogenes of Human Papillomavirus and Estradiol Regulate Hedgehog Signaling Activity in a Murine Model of Cervical Cancer

9 citations, May 2019 in “Experimental Cell Research”

HPV genes and estradiol increase a cancer-related signaling pathway, which may be targeted for cervical cancer treatment.

research TSPO Ligand Etifoxine Attenuates LPS-Induced Cognitive Dysfunction in Mice

5 citations, October 2020 in “Brain Research Bulletin”

Etifoxine, an anxiety drug, can lessen brain inflammation and cognitive issues in mice, partly by increasing production of protective brain steroids.

research Recent Progress in the Effect of Ferroptosis of Hepatic Stellate Cells on the Development of Liver Fibrosis

2 citations, September 2023 in “Frontiers in molecular biosciences”

Inducing ferroptosis in hepatic stellate cells is crucial for treating liver fibrosis.

research Research Advances of Tissue-Derived Extracellular Vesicles in Cancers

April 2024 in “Journal of cancer research and clinical oncology”

Tissue-derived extracellular vesicles are crucial for cancer diagnosis, prognosis, and treatment.

Generating Detailed Intercellular Communication Patterns in Psoriasis at the Single-Cell Level Using Social Networking, Pattern Recognition, and Manifold Learning Methods to Optimize Treatment Strategies

research Generating Detailed Intercellular Communication Patterns in Psoriasis at the Single-Cell Level Using Social Networking, Pattern Recognition, and Manifold Learning Methods to Optimize Treatment Strategies

January 2024 in “Aging”

New insights into cell communication in psoriasis suggest innovative drug treatments.

Advances in Mitochondria-Centered Mechanism Behind the Roles of Androgens and Androgen Receptor in the Regulation of Glucose and Lipid Metabolism

research Advances in Mitochondria-Centered Mechanism Behind the Roles of Androgens and Androgen Receptor in the Regulation of Glucose and Lipid Metabolism

October 2023 in “Frontiers in endocrinology”

Androgens and androgen receptors are important for metabolic health, affecting how the body uses glucose and fats through mitochondrial function.

research The Protective Role of miR-486 for Alopecia Areata

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

miR-486 may help prevent hair loss in alopecia areata.

research Blue Light Stimulatory Effect on Hair Growth Mediated by Opsin and Cryptochrome Photoreceptors

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blue light can help hair grow by affecting certain receptors in hair follicles.

research Interest of Panax Ginseng and Albizia Julibrissin Extracts to Prevent Age-Related Hair Density Reduction

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Ginseng and Albizia extracts may help prevent age-related hair thinning.

research Interest of Biotrinine, a Mix of Nasturtium Officinale and Tropaeolum Majus Extracts, for Chronic Hair Loss Treatment

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Biotrinine® may be an effective treatment for chronic hair loss.

research Cannabinoid Signaling in the Skin: Therapeutic Potential of the Cutaneous Cannabinoid System

142 citations, March 2019 in “Molecules/Molecules online/Molecules annual”

Cannabinoids may help treat various skin conditions.

research Ethnodermatological Use of Medicinal Plants in India: From Ayurvedic Formulations to Clinical Perspectives – A Review

57 citations, October 2021 in “Journal of ethnopharmacology”

Indian herbal medicine shows promise for treating skin diseases but needs more research to prove effectiveness.

research Implication of MicroRNA Regulation in Para-Phenylenediamine-Induced Cell Death and Senescence in Normal Human Hair Dermal Papilla Cells

8 citations, March 2015 in “Molecular Medicine Reports”

Hair dye ingredient PPD causes cell death and aging in human hair cells by altering microRNA levels.

research Autophagy Dysfunction: The Kernel of Hair Loss?

May 2024 in “Clinical Cosmetic and Investigational Dermatology”

Manipulating cell cleanup processes could help treat hair loss.

research Minoxidil Exerts Skin Rejuvenation Effects in Human Androgenetic Alopecia Xenotransplants In Vivo

September 2024 in “Journal of the American Academy of Dermatology”

Minoxidil helps hair regrowth and has anti-aging effects on hair follicles.

research Epithelially Derived, Mitochondrial MPZL3 Negatively Regulates Murine and Human Hair Follicle Cycling

April 2023 in “Journal of Investigative Dermatology”

A protein called MPZL3 in mitochondria slows down hair growth and could be a target for treating hair growth disorders.

research Targeting Oxidative Stress and Mitochondrial Dysfunction in the Treatment of Impaired Wound Healing: A Systematic Review

280 citations, July 2018 in “Antioxidants”

Treatments that reduce oxidative stress and fix mitochondrial problems may help heal chronic wounds.

Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research

research Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research

123 citations, December 2015 in “Journal of Neuroendocrinology”

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

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Related Terms

Research

research Cyanidin 3-O-Arabinoside Suppresses DHT-Induced Dermal Papilla Cell Senescence by Modulating p38-Dependent ER-Mitochondria Contacts

research Hunting the Hair Cycle Clock: Evidence That Mitochondrially Localized MPZL3 Is a Key Element in Murine and Human Hair Follicles

research A Novel Link Between Human Hair Follicle Neuroimmunology and Mitochondrial Biology: Substance P Increases Intrafollicular Oxidative Stress and Mitochondrial Biogenesis

research Does Mitochondrial Dysfunction Drive Immune Privilege Collapse in Lichen Planopilaris Pathogenesis?

research OsUEV1B, a Ubc Enzyme Variant Protein, Is Required for Phosphate Homeostasis in Rice

research N-Terminal Functional Domain of Gasdermin A3 Regulates Mitochondrial Homeostasis via Mitochondrial Targeting

research Molecular Basis of Hair Cell Loss

research Expression and Roles of Steroidogenic Acute Regulatory (StAR) Protein in Non-Classical, Extra-Adrenal, and Extra-Gonadal Cells and Tissues

research Calcium Regulation of Stem Cells

research The E6/E7 Oncogenes of Human Papillomavirus and Estradiol Regulate Hedgehog Signaling Activity in a Murine Model of Cervical Cancer

research TSPO Ligand Etifoxine Attenuates LPS-Induced Cognitive Dysfunction in Mice

research Recent Progress in the Effect of Ferroptosis of Hepatic Stellate Cells on the Development of Liver Fibrosis

research Research Advances of Tissue-Derived Extracellular Vesicles in Cancers

research Generating Detailed Intercellular Communication Patterns in Psoriasis at the Single-Cell Level Using Social Networking, Pattern Recognition, and Manifold Learning Methods to Optimize Treatment Strategies

research Advances in Mitochondria-Centered Mechanism Behind the Roles of Androgens and Androgen Receptor in the Regulation of Glucose and Lipid Metabolism

research The Protective Role of miR-486 for Alopecia Areata

research Blue Light Stimulatory Effect on Hair Growth Mediated by Opsin and Cryptochrome Photoreceptors

research Interest of Panax Ginseng and Albizia Julibrissin Extracts to Prevent Age-Related Hair Density Reduction

research Interest of Biotrinine, a Mix of Nasturtium Officinale and Tropaeolum Majus Extracts, for Chronic Hair Loss Treatment

research Cannabinoid Signaling in the Skin: Therapeutic Potential of the Cutaneous Cannabinoid System

research Ethnodermatological Use of Medicinal Plants in India: From Ayurvedic Formulations to Clinical Perspectives – A Review

research Implication of MicroRNA Regulation in Para-Phenylenediamine-Induced Cell Death and Senescence in Normal Human Hair Dermal Papilla Cells

research Autophagy Dysfunction: The Kernel of Hair Loss?

research Minoxidil Exerts Skin Rejuvenation Effects in Human Androgenetic Alopecia Xenotransplants In Vivo

research Epithelially Derived, Mitochondrial MPZL3 Negatively Regulates Murine and Human Hair Follicle Cycling

research Targeting Oxidative Stress and Mitochondrial Dysfunction in the Treatment of Impaired Wound Healing: A Systematic Review

research Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research

research Reversing Wrinkled Skin and Hair Loss in Mice by Restoring Mitochondrial Function

research Air Pollution, Autophagy, and Skin Aging: Impact of Particulate Matter on Human Dermal Fibroblasts

research Defects in Mitochondrial DNA Replication and Oxidative Damage in Muscle of mtDNA Mutator Mice