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This case study describes a child with rickets and alopecia who responded to a small dose of 1-a-hydroxyvitamin D3, but her alopecia remained unchanged despite treatment.

Vitamin D and zinc may help treat alopecia areata.

This study described the clinical and genetic features of two Iranian siblings with hereditary vitamin D resistant rickets, identifying a specific VDR gene mutation contributing to their symptoms.

In their mouse study, Oda et al. found that removing the MED1 gene in the skin led to hair loss and changes in epidermal cell differentiation, indicating MED1's significant role in these processes.

Hairless protein helps control hair growth by regulating vitamin D receptor activity.

This study identified two distinct VDR gene mutations among Lebanese families with hereditary vitamin D-resistant rickets, noting varied treatment responses and promising outcomes despite severe phenotypes.

This article highlights a lack of published data on vitamin D deficiency prevalence among individuals with central centrifugal cicatricial alopecia, despite its known link to other forms of hair loss.

This study found that certain VDR gene polymorphisms are more prevalent in female pattern hair loss patients than in healthy controls, suggesting these polymorphisms may increase disease risk.

This study found that a hypomorphic mutation in the Hr gene contributes to the development of diet-induced pruritic atopic skin in mice, particularly when combined with dietary deficiencies of polyunsaturated fatty acids and starch.

This article reviews the role of vitamin D and its metabolites in regulating calcium homeostasis and highlights their effects on the intestine, kidney, bone, and parathyroid gland, without reporting new clinical results.

This study observed wide clinical diversity among five patients with the same VDR gene mutation causing vitamin D-dependent rickets type II, suggesting involvement of a nuclear accessory factor and a nongenomic action of the vitamin.

This study demonstrated that VD3 significantly enhanced the proliferation and differentiation of epidermal stem cells in a murine skin defect model, leading to improved wound healing, potentially through activation of the PI3K signaling pathway.

This review discusses the involvement of vitamin D and its receptor in hair health, focusing on different types of alopecia, but reports no new clinical results; evidence remains inconsistent.

This study found that the vitamin D receptor plays a crucial role in hair follicle development in cashmere goats by regulating signaling pathways in dermal papilla cells.

This review examines how vitamin D and its receptor regulate various skin functions, such as cell differentiation and immunity, and explores the mechanisms involved, without reporting new clinical results.

This study found that treating patchy alopecia areata with fractional CO2 laser and topical triamcinolone acetonide was more effective and safer than intralesional triamcinolone, despite higher initial discomfort, as it resulted in greater patient satisfaction and fewer adverse effects like skin atrophy.

This study found that deleting the vitamin D receptor from specific stem cells in mouse hair follicles disrupts their ability to regenerate the epidermis after injury, suggesting an essential interaction with the transcription factor p63.

In this study, a novel VDR gene mutation was identified in a child with HVDRR, and the researchers observed that high-dose intravenous calcium therapy led to significant and sustained improvement in rickets symptoms.

The mutation causes hairless mice due to mislocalized and dysfunctional HR protein.

This study found that vitamin D supplementation in diets of Rex rabbits improved hair follicle development and fatty acid metabolism, with 1400–2100 IU/kg proving most effective for hair density and 2800 IU/kg increasing hair length.

This study suggests that low-cost videomicroscopes may not be reliable for diagnosing hair and scalp disorders due to limitations in color quality and resolution.

This study suggests that low-cost videomicroscopes may inaccurately assess certain features in hair and scalp disorders compared to standard videodermatoscopy, limiting their reliability for trichoscopy.

This study found that patients with alopecia, particularly alopecia areata and female pattern hair loss, often have vitamin D deficiency, suggesting that screening for vitamin D could benefit these patients.

This study found that vitamin D levels were lower in alopecia areata patients, with trichoscopic features like broken hairs and black dots more prevalent in cases with vitamin D deficiency.

The authors maintain there is a significant link between vitamin D deficiency and central centrifugal cicatricial alopecia in Black patients, and call for more research on the topic.

In this study, researchers used transcriptome sequencing to identify 1543 differentially expressed genes between cashmere and normal goats, implicating several signaling pathways and key regulators in the distinct gene expression profiles linked to cashmere fiber production, which advances understanding of cashmere goat genetics.

This study found that mice lacking both vitamin D and calcium-sensing receptors in epidermal keratinocytes are predisposed to developing squamous cell carcinoma as they age, due to impaired oxidative stress response and reduced DNA repair capabilities.

This review discusses the role of vitamin D receptor signaling in hair follicle biology for alopecia treatment and underscores the need for continued research, without presenting new clinical results.

This study observed that in human scalp hair follicles, BTNL2 expression is lower in stressed conditions, which correlates with increased cytotoxic activity by gamma/delta and CD8+ T cells, suggesting a possible role for BTNL2 in controlling immune responses relevant to alopecia areata.

This review highlights the potential role of vitamin D and its analogs in managing alopecia areata, noting that vitamin D deficiency and altered receptor expression may be linked to disease severity and that supplementation could help reduce severity and relapse rates.