7 citations
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January 2015 in “International Journal of Trichology” This case report describes a woman who experienced frontal edema after topical minoxidil application following mesotherapy, noting that excessive absorption of minoxidil may cause localized vasodilatory side effects.
15 citations
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August 1989 in “Archives of Dermatology” This article hypothesizes that minoxidil may act as an endothelium-derived relaxing factor agonist, which could explain both its vasodilatory properties and its potential effect on hair growth; however, it reports no new experimental results.
May 2025 in “Current Drug Safety” In this case study, a 17-year-old male using topical minoxidil 5% for beard growth developed peripheral edema, which resolved after discontinuing the drug, highlighting a rare but significant systemic side effect of minoxidil's use.
66 citations
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September 1982 in “Biochemical Pharmacology” This study identified a sulfotransferase activity in rat liver that catalyzes the sulfation of minoxidil, contributing to its delayed hypotensive effects.
September 2025 in “Scientific periodicals of Ukraine” This study reports on a 46-year-old patient with pseudopelades of Brocq, highlighting the effectiveness of early diagnosis and treatment in preventing atrophy and controlling hair loss, as positive clinical outcomes were noted after prescribed therapy.
34 citations
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June 2015 in “Journal of cardiovascular pharmacology and therapeutics” This article discusses the use of direct vasodilators and sympatholytic agents in hypertension management, highlighting their utility in specific cases like refractory hypertension and heart failure, but reports no new clinical results.
109 citations
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July 1984 in “Circulation” This study found that long-term minoxidil treatment, despite improving hemodynamics and left ventricular function, was associated with more frequent clinical events and a poorer clinical course in patients with chronic left ventricular failure.
11 citations
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March 2007 in “Journal of Hypertension” This article provides contact information for Professor A. Brew Atkinson and reports no new research findings; it is not a study abstract.
18 citations
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March 2004 in “Clinics in Dermatology” This review discusses recent advances in understanding the cellular, molecular, and genetic factors contributing to lupus erythematosus and reports no new experimental findings.
In this study, Minoxidil and other treatments prevented alopecia in mice induced by Paclitaxel, with quantitative data supporting the inhibition of hair loss.
1 citations
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January 2025 in “World Journal of Emergency Medicine” This case report highlights a 37-year-old male who developed coronary vasospasm, resembling Prinzmetal angina, shortly after starting oral minoxidil for hair loss, emphasizing the need to consider drug-induced vasospasm in chest pain assessments even when coronary artery disease is absent.
September 2024 in “Dermatology Online Journal” This report describes a case where a 24-year-old woman developed severe ear and face hypertrichosis after using 5% topical minoxidil, which resolved three months after discontinuation.
February 2024 in “Cosmoderma” This review discusses the use of low-dose oral minoxidil for patterned hair loss and reports it may offer improved compliance and safety compared to topical minoxidil, but provides no new clinical findings.
4 citations
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October 2013 in “Springer eBooks” This chapter reviews existing knowledge about melatonin's MT₁ and MT₂ receptors in human tissues, discussing their established and potential functions, but reports no new clinical findings.
3 citations
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August 2020 in “Journal of Cosmetic Dermatology” In this study, topical nitroglycerine spray successfully prevented impending necrosis in 94% of hair transplant cases showing signs of vascular distress.
1 citations
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February 2024 in “Peer Review” This study reviewed the use of rosemary essential oil combined with photobiomodulation for treating androgenetic alopecia, highlighting the potential benefits of rosemary's antioxidant and vasodilatory properties alongside enhanced cellular processes from photobiomodulation.
1 citations
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August 1989 in “Archives of Dermatology” This article reviews recent discoveries about the role of the nitroxide free radical NO in vascular physiology and suggests potential implications for minoxidil's vasodilatory action, but reports no new clinical findings.
February 2025 in “Medico Research Chronicles” In this clinical study, Verilich hair serum significantly reduced hair shedding by 40% or more in 75% of female patients with Telogen Effluvium and Female Pattern Hair Loss after one month of use.
15 citations
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July 1991 in “International Journal of Dermatology” This article discusses the technique of laser Doppler velocimetry for measuring cutaneous blood flow and does not report new research findings.
15 citations
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August 1988 in “Archives of Otolaryngology - Head and Neck Surgery” This paper reports a case of severe hypertrichosis in the external ear canal due to minoxidil use, leading to chronic otitis externa and hearing loss.
6 citations
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October 2011 in “Archives de pédiatrie” This case report describes a young girl who experienced vasoplegic shock and prolonged tachycardia after ingesting hair lotion containing minoxidil, highlighting the need for extended monitoring due to potential persistent hemodynamic issues.
3 citations
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August 2022 in “Molecules/Molecules online/Molecules annual” This study found that microbial adenosine and biotin treatments derived from Staphylococcus epidermidis Cicaria culture may help inhibit hair loss by maintaining the hair's growth phase.
November 1991 in “PubMed” This study observed that a 2% topical minoxidil solution was beneficial in 63% of male patients with androgenic alopecia, although only 6.6% experienced dramatic cosmetic improvement.
November 2024 in “Journal of Drugs in Dermatology” This article highlights the need for a comprehensive review of injectable minoxidil for hair loss, as existing treatments primarily focus on topical and oral forms of the medication.
January 2017 in “Zenodo (CERN European Organization for Nuclear Research)” This research investigated the formulation of minoxidil emulgel using various gelling agents for treating male pattern baldness. It found that this formulation was feasible, with no interactions between the drug and polymers, suggesting potential advantages over other dosage forms.
March 1985 in “Journal of the American Academy of Dermatology” This research found that topical minoxidil may promote hair regrowth in alopecia areata by stimulating hair follicle epithelium and suppressing certain immune responses, with potential contributions from its vasodilatory effects.
September 2025 in “Ukrainian Journal of Dermatology Venerology Cosmetology” In this case study, a patient with pseudopelades of Brocq was treated with a peripheral vasodilator, B vitamins, and corticosteroid lotion, leading to halted hair loss and improved clinical symptoms over seven weeks.
This literature review explores the mechanism of action, pharmacokinetics, safety, and efficacy of low-dose oral minoxidil as a treatment for various non-androgenic types of alopecia, finding it to be a promising alternative for these conditions despite the need to establish optimal dosing for different demographics.
November 2019 in “Actas Dermo-Sifiliográficas” This article discusses the historic use of oral minoxidil for severe hypertension and the subsequent development of a topical formulation for treating pattern hair loss, but reports no new results.
January 2025 in “Journal of Materials Chemistry B” A new treatment using special microneedles and a nitric oxide-releasing drug could improve hair growth and be more convenient for people with hair loss.