2 citations
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March 2023 in “Frontiers in Bioengineering and Biotechnology” This study found that CuO/SiO2 nanowires enhanced with photothermal therapy exhibit significant antibacterial effects against E. coli and S. aureus and promote wound healing and vascularization, suggesting potential as an alternative treatment for infected wounds in mouse models.
1 citations
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July 2023 in “International Journal of Biological Macromolecules” In this study, researchers developed a composite paste system using minoxidil-loaded nanoparticles and valproic acid, enhanced by roller-microneedles, which significantly stimulated hair regeneration and perifollicular vascularization in an androgenetic alopecia mouse model, reducing side effects compared to traditional treatments.
1 citations
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June 2023 in “Journal of Cellular and Molecular Medicine” This study observed that tissue-engineered skin, using VEGF165 gene-modified cells embedded in astragalus polysaccharide-containing 3D printed scaffolds, enhanced early vascularization, and collagen and hair follicle regeneration, leading to improved skin repair in nude mice with full skin defects.
June 2026 in “bioRxiv (Cold Spring Harbor Laboratory)” This study evaluated petroleum jelly-based bioactive glass ointments with varying copper concentrations for wound healing in chronic wound models, finding that the 3 wt% copper formulation significantly improved healing by enhancing tissue regeneration, vascularization, and antibacterial protection compared to controls.
May 2026 in “Stem Cell Research & Therapy” This study found that exosomes derived from dental pulp mesenchymal stem cells (DPSC-Exos) significantly promoted hair regrowth and follicle density in a mouse model of androgenetic alopecia, showing similar efficacy to minoxidil by activating pathways that improve follicular vascularization and dermal papilla cell function.
September 2025 in “Journal of Zhejiang University (Medical Sciences)” This review highlights how peripheral nerves play key roles in skin wound healing by modulating immune responses, regulating stem cell functions, and promoting vascularization, suggesting potential avenues for therapeutic strategies targeting neuroregulation.
August 2025 in “Revista Contemporânea” This study reviewed literature on the combined use of microneedling and essential oils for treating male androgenetic alopecia, finding that this approach potentially enhances scalp vascularization and hair growth, although controlled clinical trials are needed to confirm these effects and standardize treatment protocols.
November 2023 in “International Journal of Pharmaceutics” This study found that a new transdermal drug delivery system using globefish skin collagen peptides and dissolving microneedles effectively promoted hair regrowth in mice with androgenetic alopecia by reducing inflammation and enhancing vascularization.
This study found that GPC1 is a key regulator of angiogenesis in hair follicles and may be an interesting target for addressing alopecia in dermatology research.
2 citations
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July 2022 in “The Kaohsiung Journal of Medical Sciences” This study demonstrated that the immunomodulatory drug FTY720 may enhance the survival of allogeneic fat grafts in mice by reducing immune rejection and improving neovascularization.
6 citations
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January 2025 in “World Journal of Orthopedics” This review discusses the use of platelet rich plasma in ACL reconstruction, indicating potential benefits in early healing and complication reduction, but notes inconsistent long-term outcomes and a need for more research.
1 citations
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June 2021 in “Problems of Cryobiology and Cryomedicine” In this study on rats, CBF injections demonstrated significant wound healing effects and improved recovery after skin cryoablation, similar to the effects observed with Actovegin.
January 2026 in “Frontiers in Cell and Developmental Biology” This review discusses the molecular mechanisms and clinical applications of autologous platelet-derived products for TMJ regeneration, but reports no new clinical results.
November 2025 in “ACS Omega” This study found that incorporating Canavalia ensiformis lectin into alginate and carboxymethylcellulose films enhanced angiogenic factor expression, suggesting these biopolymer films could be an effective alternative for wound treatment.
July 2024 in “Frontiers in Bioengineering and Biotechnology” In this mouse study, the researchers found that cryopreserving nanofat at -20°C maintained its viability and regenerative potential, comparable to freshly generated nanofat, supporting its potential for repeated use in regenerative applications.
This study found that GPC1 plays a crucial role in regulating angiogenesis in human dermal microvascular endothelial cells, which may make it a potential target in alopecia treatment research.
November 2021 in “Research Square (Research Square)” This study found that 4-aminopyridine significantly improves skin wound healing by enhancing various cellular and molecular processes, suggesting its potential for rapid translational development in wound treatment.
October 2006 in “Urology” The document aimed to understand how certain treatments affect blood vessel growth in rat prostates.
192 citations
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January 2018 in “Burns & Trauma” This review discusses the advancements in biologic skin substitutes for wound treatment and their potential in enhancing cutaneous regeneration but reports no new clinical results.
187 citations
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April 2019 in “npj Regenerative Medicine” This study found that hMSC secretomes from umbilical cord Wharton's jelly had the most potent angiogenic effects, whereas those from adipose tissue demonstrated the weakest angiogenic potential.
88 citations
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July 2020 in “Frontiers in Cell and Developmental Biology” In this review, bioengineered materials incorporating growth factors and cytokines were reported to enhance wound healing by sustaining drug delivery, reducing dosage, and minimizing side effects compared to traditional treatments.
48 citations
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December 2022 in “Biomolecules” This review discusses recent advancements in 3D bioprinting for skin regeneration and describes potential improvements for clinical applications, but it reports no new experimental results.
38 citations
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January 2017 in “Mediators of Inflammation” This study found that platelet-rich growth factor significantly reduced the release of proinflammatory cytokines in an in vitro rheumatoid arthritis model.
34 citations
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January 2022 in “Frontiers in Immunology” This study found that IL-25-mediated-IL-17RB signaling improved diabetic wound healing by enhancing angiogenesis, collagen deposition, and endothelial cell function, suggesting a potential therapeutic strategy for poorly healing diabetic wounds.
34 citations
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May 2021 in “Journal of Nanobiotechnology” This study found that electrospun short fibrous sponges effectively mimic the 3D extracellular matrix, promoting tissue regeneration, angiogenesis, and wound healing in diabetic rats better than 2D fiber membranes.
15 citations
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January 2024 in “Journal of Materials Chemistry B” In this study, researchers developed an injectable silk fibroin-based hydrogel that enhances wound healing by protecting against oxidative stress and promoting tissue repair, outperforming commercial wound dressing Tegaderm™ in animal models.
12 citations
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September 2024 in “MedComm” This review reports on the principles, applications, and future potential of bioprinting technology in fields like tissue engineering and organ regeneration, highlighting recent advancements and identifying ongoing challenges and future directions that require collaborative efforts to fully realize the technology's capabilities.
12 citations
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September 2023 in “Polymers” This study reported that a newly developed hydrogel composed of recombinant type I collagen and chitosan, incorporating a metal–polyphenol structure, demonstrated strong mechanical and healing properties, effectively promoting wound healing in a full-thickness skin defect model.
12 citations
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April 2023 in “Frontiers in Materials” This review discusses the biofunctionalization of hydrogel scaffolds for vascular tissue regeneration and reports promising results from in vivo studies, such as improved angiogenesis and healing in pressure ulcers when using specific peptides.
11 citations
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July 2024 in “Biomimetics” This manuscript explores the development and future potential of injectable biomimetic gels in biomedical applications, highlighting their promise in wound healing and tissue regeneration, while also acknowledging challenges like mechanical durability and scalable production still persist.