January 2025 in “Journal of Controlled Release” This study developed a gas-propelled microneedle patch with puerarin/quercetin nanoparticles, which demonstrated improved hair-regenerating effects in an androgenetic alopecia mouse model by increasing drug delivery, alleviating oxidative stress, promoting angiogenesis, and rejuvenating senescent cells.
January 2025 in “Regenerative Biomaterials” In this study, a new pH-responsive hydrogel composed of polyvinyl alcohol and boric acid was found to release salvianolic acid B effectively, reducing excessive scar formation and enhancing tissue regeneration during early-stage wound healing.
January 2025 in “Regenerative Biomaterials” This study found that a microneedle patch with recombinant collagen XVII significantly improved hair coverage, follicle density, and angiogenesis in an androgenic alopecia mouse model, showing potential as a novel therapeutic strategy alongside established treatments like minoxidil.
This case report describes a patient with alopecia areata who showed visible hair growth after two months of topical treatment with MSC-derived Conditioned Media, suggesting potential benefits for hair regrowth.
June 2024 in “International journal of biological macromolecules” This study reports that beta-glucan hybrid hydrogels, reinforced with laponite nanoclay, showed promising results in rat models for managing hemorrhage and diabetic wound healing by enhancing hemostasis, reducing inflammation, and promoting faster wound closure and tissue regeneration.
May 2024 in “Chemical engineering journal” This study reports that a new minoxidil and epigallocatechin gallate co-loaded ionic liquids system showed superior efficacy in promoting hair regrowth in a mouse model of androgenic alopecia by activating hair follicle stem cells and improving microenvironment conditions, compared to existing minoxidil products.
December 2023 in “Aggregate” In this review, it is discussed how mesenchymal stem cell aggregation plays a crucial role in organ development and has potential applications in organ regeneration through tissue engineering.
August 2023 in “European Journal of Plastic Surgery” This study found that although three-dimensional bioprinting in plastic and reconstructive surgery is rapidly advancing, complete tissue systems have not yet been successfully printed due to ongoing challenges.
This study found that an injectable hydrogel, SF-g-SDA, outperformed commercial Tegaderm™ in healing wounds, promoting collagen deposition, and enhancing neovascularization in animal models.
November 2022 in “Journal of Investigative Dermatology” This study observed that three-dimensional cultures of dermal papilla cells enhanced endothelial cell migration and angiogenesis in vitro, which may improve vascularization in tissue-engineered skin constructs.
This chapter reviews bioengineered human hair follicles and discusses the pros and cons of different 3-D bioprinting methods, but reports no new experimental findings.
March 2021 in “Research Square (Research Square)” This research observed that 3D electrospun micro/nanofibrous sponges, without using chemical crosslinking agents, supported enhanced cell growth, vascularization, and skin regeneration in diabetic rats compared to 2D fiber membranes, making them promising for 3D tissue regeneration.
April 2020 in “Rice Research Repository (Rice University)” This study suggests that MultiDomain Peptide hydrogels may support wound healing in diabetic mice by accelerating closure and promoting tissue regeneration, though they did not inhibit bacterial growth in infected wounds as expected.
June 2019 in “The Egyptian Journal of Histology” In this study, hyaluronic acid filler injections in albino rats increased subcutaneous tissue thickness, collagen and elastic fibers, and vascularization, suggesting potential benefits for combating skin aging and defects.
April 2018 in “Cytotherapy” This article reviews the potential of PRP and adipose-derived stem cell treatments for hair growth, but provides no new clinical results, calling for more research in these areas.
December 2017 in “Facial plastic surgery” In this review, the authors discuss how advanced hair transplantation techniques can improve the aesthetic outcome of facial trauma involving hair-bearing areas, emphasizing the role of adjuvant therapies like fat transfer and platelet-rich plasma to enhance hair regrowth.
In this study, subcutaneous injection of mesenchymal stem cell-conditioned medium promoted regeneration of mice skin aged by D-galactose, improving skin thickness, vascularization, and collagen density.
January 2017 in “DR-NTU (Nanyang Technological University)” This study observed that keratin sponges showed comparable biocompatibility to a commercial positive control in mice, but keratin gels had slightly inferior biocompatibility.
This study found that dermal papilla-like tissues derived from canine adipose stem cells promoted new hair follicle formation and increased vascularization in athymic nude mice.
April 2011 in “The FASEB Journal” This study found that profilin1 protein significantly accelerated wound healing in transgenic mice by reducing wound size and enhancing vascularization and cell migration compared to nontransgenic and 88R/L mice.
This study found that keratin-gelatin composite films effectively promoted early wound healing and full-thickness skin graft acceptance in dogs, outperforming bFGF-gelatin films.
January 2007 in “Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia)” This study concluded that keratin-gelatin composite films were more effective than bFGF-gelatin films in promoting early and uncomplicated wound healing in dogs, observing improved epithelialization and graft acceptance.
January 2003 in “Jiepouxue zazhi” This study found that human hair keratin can serve as a matrix for skin structure restoration, as observed in rats where the graft was replaced by newly formed collagenous fibers over six weeks.
October 1982 in “American Journal of Nursing” Wound healing is a complex process involving different cells and stages, leading to scar tissue formation and strength increase over time.
520 citations
,
February 2001 in “Journal of Clinical Investigation” This study found that VEGF significantly enhances perifollicular vascularization during the hair growth phase, accelerating hair regrowth and increasing follicle and hair size, while its inhibition retards hair growth.
76 citations
,
March 2005 in “Cancer Research” This study in ND-GFP transgenic mice found doxorubicin inhibited both tumor angiogenesis and growth, visualized through dual-color fluorescence imaging of nascent blood vessels and melanoma cell lines.
52 citations
,
January 2003 in “Journal of Investigative Dermatology” This study found that thrombospondin-1 plays a critical role in hair follicle cycle regulation, with deficiency prolonging follicle growth and overexpression delaying it through antiangiogenic effects.
45 citations
,
July 2009 in “Journal of Investigative Dermatology” This study reported significant upregulation and release of S100A4 in psoriatic skin, which may actively contribute to psoriasis pathogenesis.
17 citations
,
August 2003 in “Ultrasound in Obstetrics and Gynecology” This review discusses the complexities of diagnosing polycystic ovary syndrome and reports no new results; the authors suggest a thorough and careful diagnostic approach to avoid misdiagnosis and unnecessary tests.
12 citations
,
August 2022 in “Journal of Controlled Release” In this study, a microneedle patch containing conditioned media from hypoxia-pretreated stem cells enhanced hair regeneration in an androgenetic alopecia mouse model by boosting perifollicular vascularization and hair follicle stem cell activation compared to minoxidil.