Search

for
Search:

Did you mean Vascularization?

Glossary Vascularization

process of forming new blood vessels in tissue

Vascularization refers to the process by which new blood vessels form within a tissue. This is crucial for delivering oxygen and nutrients to tissues, promoting healing, and supporting the growth of new cells. In the context of hair and alopecia, proper vascularization of the scalp is essential for healthy hair growth, as it ensures that hair follicles receive the necessary nutrients and oxygen.

Related Terms

Sort by

Research

30 / 1000+ results

research Micropatterned composite membrane guides oriented cell growth and vascularization for accelerating wound healing

19 citations , December 2022 in “Regenerative Biomaterials”

This study found that gelatin–polycaprolactone/silk fibroin composite membranes with line micropatterns enhanced wound healing in rats by promoting cell alignment, angiogenesis, and increased α-SMA production.

research Gfp-Expressing Vascularization of Gelfoam® as a Rapid in Vivo Assay of Angiogenesis Stimulators and Inhibitors

15 citations , March 2007 in “BioTechniques”

This study introduced a new in vivo angiogenesis assay using Gelfoam implanted in ND-GFP transgenic mice to efficiently identify angiogenesis stimulators and inhibitors through GFP visualization.

research Multipotent adult progenitor cells grown under xenobiotic-free conditions support vascularization during wound healing

4 citations , September 2020 in “Stem Cell Research & Therapy”

In this study, xenobiotic-free human multipotent adult progenitor cells were found to improve wound vascularization and healing in mice, suggesting potential applicability for clinical use in humans.

research 3D multicellular micropatterning biomaterials for hair regeneration and vascularization

3 citations , January 2023 in “Materials horizons”

This study developed 3D micropatterns with magnesium silicate nanospheres that mimic vessels and hair follicles for potential use in skin regeneration by reconstructing vasculature and promoting hair growth.

research Hypoxic Preconditioned Nanofat at 1% O2 for 24 h Loses Its Regenerative In Vivo Vascularization Capacity

January 2026 in “Cells”

This study found that hypoxic preconditioning of nanofat from donor mice reduced its vascularization capacity in vivo, suggesting that this approach cannot currently enhance nanofat's regenerative potential.

research Vascularization of skin substitute constructed by vascular endothelial growth factor 165 gene-modified hair follicle stem cells compounded with three-dimensional gelatin-chondroitin sulfate-hyaluronic acid

June 2014

This study found that a modified scaffold with VEGF165 genetically modified hair follicle stem cells significantly promoted blood vessel growth and wound healing in rats, suggesting its potential as a skin substitute in clinical settings.

The Effects of Negative Pressure by External Tissue Expansion Device on Epithelial Cell Proliferation, Neo-Vascularization, and Hair Growth in a Porcine Model

research The Effects of Negative Pressure by External Tissue Expansion Device on Epithelial Cell Proliferation, Neo-Vascularization and Hair Growth in a Porcine Model

16 citations , April 2016 in “PLoS ONE”

In a porcine model, this study observed that using an External Tissue Expansion Device increased epidermis thickness, cell proliferation, and vessel density at fat graft recipient sites.

Perifollicular Vascularization: Cocultures and Tricultures Approaches to Study the Cross-Talk Between Microvascular Endothelial Cells, Follicle Papilla Cells, and Keratinocytes

research Perifollicular vascularization: Cocultures and tricultures approaches to study the cross-talk between microvascular endothelial cells, follicle papilla cells and keratinocytes

December 2015 in “Vascular Pharmacology”

Hair papilla cells are crucial for blood vessel development in hair follicles, affecting hair growth and loss.

Poor Perifollicular Vascularization Is Associated With Nutrient Insufficiency and a Quiescent Metabolic Phenotype in Intermediate Hair Follicles From Patients With Female Pattern Hair Loss

research 333 Poor perifollicular vascularization is associated with nutrient insufficiency and a quiescent metabolic phenotype in intermediate hair follicles from patients with female pattern hair loss

October 2021 in “Journal of Investigative Dermatology”

In this study, the researchers found that scalp hair follicles affected by female pattern hair loss are poorly vascularized, likely affecting nutrient delivery, but capable of nutrient uptake when supplemented.

research Scalp vascularization as a marker of topical minoxidil treatment efficacy in patients with androgenetic alopecia

March 2021 in “Postepy Dermatologii I Alergologii”

In this study, topical 5% minoxidil significantly increased total hair count in women with female pattern hair loss after 6 months, and scalp vascularization did not affect treatment efficacy.

research Heat Preconditioning of Nanofat Does Not Improve Its Vascularization Properties

2 citations , April 2025 in “Cells”

This study found that heat preconditioning of nanofat from mice did not improve tissue vascularization or integration in grafting, and actually reduced vascularization due to increased expression of anti-angiogenic factors, suggesting it is not beneficial for enhancing its vascularization properties.

research Hormone replacement therapy and the skin

138 citations , May 2000 in “Maturitas”

This review discusses the effects of estrogen on skin and reports no new clinical results; it highlights estrogen's potential benefits on skin thickness, collagen quality, and hair follicle life cycle.

Gelatin-Chondroitin-6-Sulfate-Hyaluronic Acid Scaffold Seeded with Vascular Endothelial Growth Factor 165 Modified Hair Follicle Stem Cells as a Three-Dimensional Skin Substitute

research Gelatin-chondroitin-6-sulfate-hyaluronic acid scaffold seeded with vascular endothelial growth factor 165 modified hair follicle stem cells as a three-dimensional skin substitute

45 citations , October 2014 in “Stem cell research & therapy”

This study found that using 3D Gel-C6S-HA scaffolds seeded with VEGF165-modified rat hair follicle stem cells enhanced angiogenesis and vascularization in tissue-engineered skin, improving wound healing.

research Fish Acellular Dermal Matrix Promotes Repair of Full‐Thickness Skin Defects in Mice and Bama Pigs

1 citations , September 2025 in “Wound Repair and Regeneration”

This study found that an acellular dermal matrix derived from tilapia skin significantly accelerated wound healing and improved tissue regeneration quality in mouse and pig models compared to a commercial porcine-derived matrix, suggesting its potential as a safe, cost-effective bioscaffold for skin repair.

research Skin Organoids for Disease Modelling, Drug Screening and Regenerative Medicine: Recent Advances and Future Perspectives

January 2026 in “Wound Repair and Regeneration”

This review summarizes the latest progress and challenges in skin organoid research, emphasizing advancements in organoid construction, applications in disease modeling, and factors affecting tissue maturation, while noting barriers such as vascularization and neural integration that hinder clinical translation.

research “How can stem cells improve the function of skin grafts”

January 2025

This abstract introduces 3D bioprinted skin grafts as a promising alternative to traditional skin grafts, emphasizing how using stem cells in the bioink can enhance vascularization and hair follicle regeneration, potentially improving graft integration and function without the donor site risks.

research Injectable Polypeptide‐Protein Hydrogels for Promoting Infected Wound Healing

262 citations , May 2020 in “Advanced Functional Materials”

This study demonstrated that a newly developed polypeptide-protein hydrogel with vascularization and antibacterial properties promoted tissue regeneration and hair follicle formation in infected wound healing.

research 5α-reductase activity in the prostate

237 citations , December 2001 in “Urology”

This review discusses the role of 5α-reductase in prostate development and BPH, and reports no new clinical results; ongoing trials are exploring dual isozyme inhibitors for improved treatment efficacy.

research Tissue engineering; strategies, tissues, and biomaterials

203 citations , July 2017 in “Biotechnology and Genetic Engineering Reviews”

This review discusses the various components essential for successful tissue engineering, such as cell sources, modification methods, and supportive matrices, and highlights the need for functional synergy without reporting new experimental results.

research Tissue engineering of human hair follicles using a biomimetic developmental approach

184 citations , December 2018 in “Nature Communications”

This study demonstrated that enhancing human skin constructs with hair follicles through engineered cell organization and vascularization improved hair growth in immunodeficient mice, suggesting potential advances for treating alopecia and chronic wounds.

research From Hair to Cornea: Toward the Therapeutic Use of Hair Follicle-Derived Stem Cells in the Treatment of Limbal Stem Cell Deficiency

135 citations , October 2010 in “Stem Cells”

This study found that stem cells from mouse hair follicles successfully reconstructed the ocular surface in most limbal stem cell deficiency mice, demonstrating potential for treating the condition in a mouse model.

research A Concise Review on Tissue Engineered Artificial Skin Grafts for Chronic Wound Treatment: Can We Reconstruct Functional Skin Tissue In Vitro?

133 citations , July 2020 in “Cells”

This review discusses the modern approach of skin tissue engineering for chronic wound treatment, focusing on bioengineered artificial skin substitutes and assessing innovations in biomaterials and cell use; it reports no new clinical results.

research Human acellular amniotic membrane incorporating exosomes from adipose-derived mesenchymal stem cells promotes diabetic wound healing

132 citations , April 2021 in “Stem Cell Research & Therapy”

This study found that exosome-incorporated human amniotic membrane scaffolds notably enhanced diabetic skin wound healing in mice, suggesting potential applications for ADSC-derived exosomes in clinical settings.

research Reactive oxygen species–degradable polythioketal urethane foam dressings to promote porcine skin wound repair

116 citations , April 2022 in “Science Translational Medicine”

This study found that the hydrophilic PTK-UR foam with EG7 repeats significantly improved wound healing in porcine skin wounds compared to other scaffolds, suggesting potential for synthetic biomaterial applications.

research Targeted Overexpression of the Angiogenesis Inhibitor Thrombospondin-1 in the Epidermis of Transgenic Mice Prevents Ultraviolet-B-Induced Angiogenesis and Cutaneous Photo-Damage

93 citations , May 2002 in “Journal of Investigative Dermatology”

This study found that chronic ultraviolet-B exposure increased skin vascularization and wrinkle formation in mice, while overexpressing the angiogenesis inhibitor thrombospondin-1 reduced these effects, suggesting angiogenesis inhibition as a potential approach to prevent photo-damage.

research Multidomain Peptide Hydrogel Accelerates Healing of Full-Thickness Wounds in Diabetic Mice

86 citations , March 2018 in “ACS Biomaterials Science & Engineering”

This study found that MDP hydrogel significantly accelerated wound healing and improved tissue formation in diabetic mice compared to a standard clinical hydrogel and control buffer.

research Tailoring bioinks of extrusion-based bioprinting for cutaneous wound healing

82 citations , January 2022 in “Bioactive Materials”

This review discusses extrusion-based bioprinting bioinks for skin regeneration, highlighting their current applications, limitations, and potential improvements, but reports no new experimental findings.

research Transcriptome Sequencing Reveals Differences between Primary and Secondary Hair Follicle-derived Dermal Papilla Cells of the Cashmere Goat (Capra hircus)

81 citations , September 2013 in “PLoS ONE”

This study identified gene expression differences between dermal papilla cells from primary and secondary hair follicles in Cashmere goats, highlighting their roles in hair follicle morphogenesis.

Impact of Different Preparation Methods to Obtain Autologous Non-Activated Platelet-Rich Plasma and Activated Platelet-Rich Plasma in Plastic Surgery: Wound Healing and Hair Regrowth Evaluation

research Impact of the Different Preparation Methods to Obtain Autologous Non-Activated Platelet-Rich Plasma (A-PRP) and Activated Platelet-Rich Plasma (AA-PRP) in Plastic Surgery: Wound Healing and Hair Regrowth Evaluation

58 citations , January 2020 in “International Journal of Molecular Sciences”

This review evaluates various kits for isolating platelet-rich plasma using established processing standards and finds they enable compliance with consensus quality criteria; ongoing research is needed to refine these procedures for improved consistency and safety.

research Meta-analysis of efficacy of platelet-rich plasma therapy for androgenetic alopecia

57 citations , May 2016 in “Journal of Dermatological Treatment”

This analysis suggests that platelet-rich plasma therapy may be promising for treating androgenetic alopecia, but further controlled trials with standardized measures are needed to confirm its efficacy.