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The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

Late diagnosis of congenital adrenal hyperplasia can greatly affect physical development, gender identity, and sexual health.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

Polycystic ovary syndrome (PCOS) is a major health issue for women in Egypt, affecting 14% of fertile women and 37.5% of infertile women.

Hormone therapy affects hair growth in transgender individuals, with testosterone potentially causing hair loss in trans men and estrogen reducing facial/body hair in trans women; treatment options vary.

Some skin medications are safe for pregnant women, but others pose risks or should not be used.

Menopause reduces skin collagen and elasticity, and while estrogen therapy can help, its risks require careful consideration.

Primary care is key in managing PCOS, focusing on lifestyle changes and medications like birth control and metformin.

Testosterone therapy seems safe and effective for transgender men with proper care, but more long-term research is needed.

Women with congenital adrenal hyperplasia have lower fertility, but with proper treatment, they can conceive successfully.

Progestogens are essential in menopausal hormone therapy to prevent uterine cancer and must be chosen carefully based on individual needs.

More frequent and severe skin problems are linked to higher daily alcohol consumption.

Transethosomes improve drug delivery through the skin and show promise for treating various conditions.

Obesity in the U.S. is largely influenced by diet and exercise, certain medications can improve heart procedures and hair growth, and major teaching hospitals have better patient outcomes.

Women with PCOS face many health risks, but exercise, a healthy diet, and weight management can help.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

An 8-year-old girl with vitiligo developed extra hair growth on her knee after using tacrolimus ointment.

Deferasirox effectively reduces iron overload in ß-thalassemia patients but may cause some manageable side effects.

Cetuximab can cause eyelash growth, which is rare but manageable.

The definition of Polycystic Ovary Syndrome may change with new research, and careful screening is key for managing the condition.

The document concludes that accurate diagnosis of male and female gonadal disorders is crucial for effective treatment and better patient outcomes.

The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.

Women with only irregular periods or excess hair have a better hormone profile than those with full PCOS, but both groups are similar, indicating a need for better PCOS diagnosis methods.

Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.

Experts recommend thorough medical, sexual, and psychosocial assessments for women's sexual dysfunctions, and suggest individualized treatment plans with regular check-ups. They also mention potential use of estrogen and androgen therapy, but with caution due to safety concerns.

Some plants used in traditional medicine may help treat cancer because they contain proteins that can inactivate ribosomes.

Testosterone therapy can improve sexual function in women but long-term safety is unclear.

Early treatment of PCOS in teens is crucial to prevent long-term health issues like diabetes and heart disease.