research Medikamentöse Therapie des benignen Prostatasyndroms
Combining medications is more effective for treating benign prostatic syndrome symptoms.
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90-120 / 1000+ resultsresearch Long-term experiences with minoxidil in combination treatment of severe arterial hypertension.
This study found that minoxidil, used with beta-blockers and thiazides, effectively reduced blood pressure in patients with severe hypertension, although it required careful management of side effects like sodium retention and increased hair growth.
research Hair & Cutaneous Development
The document presented various studies on hair and cutaneous development, revealing insights into hair biology and potential therapeutic targets for hair-related conditions. Key findings included the role of stem cells and their niches in hair regeneration, the impact of TACE/ADAM17 depletion on alopecia, and the expression of somatostatin in hair follicles. Research on genetic factors, such as CYLD mutants and P-cadherin, highlighted their importance in hair growth and pigmentation. Studies on hair aging identified genes involved in hair loss in women over 40. Additionally, the potential of keratinocyte precursors from iPS cells for hair follicle regeneration and the effectiveness of a parathyroid hormone analog in reversing chemotherapy-induced alopecia were explored. The document also discussed the role of cholesterol biosynthesis in cicatricial alopecia, the necessity of Wnt signaling for hair follicle initiation, and the effects of ATP-sensitive potassium channel blockers on hair growth. These findings collectively advanced the understanding of hair growth, alopecia treatment, and skin regeneration.
research Medikamentöse Therapie des benignen Prostatasyndroms (BPS)
This review discusses the drug treatment of benign prostatic syndrome, highlighting the efficacy of combination therapies over monotherapies in patients at high risk for disease progression, but notes increased side effects and costs.
research Testosterone up-regulates vacuolar ATPase expression and functional activities in vas deferens of orchidectomized rats
This study found that V-ATPase plays a role in the acidification of vas deferens fluid under the influence of testosterone in orchidectomized rats.
research SnapshotDx Quiz: February 2018
This quiz article provides a series of dermatological diagnosis questions based on a Journal of Investigative Dermatology article and includes explanations but reports no original research findings.
research Stimulation of Cl conductance by minoxidil sulfate and K conductance by minoxidil in eccrine clear cells.
This study found that minoxidil sulfate stimulates Cl channels, potentially depolarization-activated and outwardly rectifying, in eccrine clear cells, while minoxidil itself stimulates Ca-insensitive K currents.
research Alopecia areata: a new treatment plan
This review discusses various therapeutic agents for alopecia areata, categorized by efficacy and safety, and highlights the lack of curative treatments and long-term outcome studies.
research Treatment of chronic prostatitis/chronic pelvic pain syndrome
This review discusses various treatment recommendations for Chronic Prostatitis/Chronic Pelvic Pain Syndrome, noting the need for further trials on herbal therapies and specific indications for surgical intervention, but reports no new clinical results.
research Risks and side effects in the medical management of benign prostatic hyperplasia
This review provides an overview of the risks and side effects associated with common medications used to treat benign prostatic hyperplasia, highlighting the importance for clinicians and patients to discuss these aspects for informed decision-making.
research Ejaculatory dysfunction in the treatment of lower urinary tract symptoms
This review discusses the impact of medical and surgical treatments for LUTS/BPH on ejaculatory function, highlighting that most treatments negatively affect it, except for some minimally invasive surgical therapies and specific medical therapies.
research Comparison of clinical trials with finasteride and dutasteride.
This review discusses the pharmacologic effects, safety, and efficacy of dutasteride and finasteride for BPH, finding similar clinical benefits but greater DHT reduction with dutasteride and reports no new trial results.
research Skin manifestations associated with COVID-19
This review examines the skin manifestations associated with COVID-19 but reports no new clinical findings, emphasizing the need for differential diagnoses to correlate skin symptoms with the virus.
research Current Therapeutic Approaches to Chronic Central Serous Chorioretinopathy
This review discusses various treatment options for chronic central serous chorioretinopathy, evaluating studies conducted since 2000, but reports no new clinical results.
research Birt–Hogg–Dubé syndrome
This review discusses recent insights into Birt–Hogg–Dube syndrome, including the functions of the FLCN gene and clinical recommendations for screening and treatment, but it reports no new experimental results.
research The Risk of Venous Thromboembolism (VTE) in Men with Benign Prostatic Hyperplasia Treated with 5-Alpha Reductase Inhibitors (5ARIs).
Men using 5-alpha reductase inhibitors for prostate issues may have a slightly higher risk of blood clots.
research Hypertension's 3 Dilemmas and 3 Solutions: Pharmacology of the Kidney in Hypertension
This article discusses the challenges in hypertension management, emphasizing the need to reconsider the use of minoxidil and address excess dietary sodium and arteriolar hypertrophy, but reports no new clinical results.
research FFA Patient Profile Analysis Based on the Authors’ Observations and a Review of the Literature—An Original Survey
This study reported that frontal fibrosing alopecia predominantly affects postmenopausal women and identified potential risk factors like frequent β-blocker use and sunscreen application, indicating the need for further research.
research Organizational Effects of Estrogens and Androgens on Estrogen and Androgen Receptor Expression in Pituitary and Adrenal Glands in Adult Male and Female Rats
This study found that neonatal blocking of androgen and estrogen pathways in rats altered sex-specific expression of estrogen and androgen receptors in adult pituitary and adrenal glands, potentially influencing lifelong neuroendocrine function.
research Catecholaminergic neurons boost fibroblast osteogenic activity in keloid
In this study, researchers identified that keloid fibroblasts respond to neurotransmitters from catecholaminergic nerves by producing bone matrix proteins, mediated by β1-adrenergic receptor activation, leading to fibro-osseous reprogramming; blocking this signaling in a rodent model prevented the development of keloid-like pathology.
research Bioactives in Nutricosmetics: A Focus on Caffeine from Tea to Coffee
This review highlights caffeine's diverse benefits in cosmetics and nutricosmetics, noting its antioxidant properties, ability to treat skin disorders like androgenic alopecia, and potential to enhance sunscreen effectiveness, though penetration into deeper skin layers remains challenging.
research Mixture effects of endocrine disrupting compounds in vitro
This study concluded that mixtures of weak endocrine disruptors, such as parabens and azole fungicides, can produce combination effects that should be considered in regulatory risk assessments to avoid underestimating potential risks.
research Sodium Valproate Improves Skin Flap Survival via Gamma-Aminobutyric Acid and Histone Deacetylase Inhibitory System
This study demonstrated that sodium valproate accelerates skin healing and reduces necrosis in a rat model of skin flap potentially through mechanisms involving GABA and histone deacetylase pathways.
research 7288 A Preclinical Mouse Model of Gender-Affirming Hormone Therapy: Metabolic and Behavioral Outcomes
This study observed that gender-affirming hormone therapy differentially affects metabolism in mice, with the specific metabolic impacts dependent on the type of hormonal treatment used.
research COVID-19 in adult patients with pre-existing chronic cardiac, respiratory and metabolic disease: a critical literature review with clinical recommendations
This review discusses the disproportionate negative impact of the COVID-19 pandemic on individuals with chronic medical conditions and calls for strategies to protect these vulnerable populations.
research Single‐cell transcriptomics reveals a senescence‐associated IL ‐6/ CCR6 axis driving radiodermatitis
This study found that targeting IL-6, IL-1, and CCR6 signaling pathways may effectively reduce irradiation-induced alopecia and dermatitis in radiotherapy patients.
research Cardiac and Renal SARS-CoV-2 Viral Entry Protein Regulation by Androgens and Diet: Implications for Polycystic Ovary Syndrome and COVID-19
This study suggests that women with polycystic ovary syndrome may have an increased risk of COVID-19-related cardiac and renal complications, and that weight loss through lifestyle changes could help reduce these risks.
research Anti-Androgens
This review discusses the causes and treatments of hirsutism in women and reports no clinical results; it emphasizes the importance of identifying androgen-secreting tumors that require distinct therapy.
research Safety of Antiandrogens for the Treatment of Female Androgenetic Alopecia with Respect to Gynecologic Malignancies
This review assessed the safety of oral antiandrogen treatments for female androgenetic alopecia, finding spironolactone to be potentially safe even in high-risk populations, but indicated ongoing uncertainty regarding other medications, especially for patients with a history of gynecologic cancers.
research The Cutaneous Epidermal Growth Factor Network: Can it be Translated Clinically to Stimulate Hair Growth? - eScholarship
This study reports that blocking the epidermal growth factor receptor in cancer treatments can lead to changes in hair growth and create a "wavy" hair phenotype in some patients.