research Final Report on the Safety Assessment of Hypericum Perforatum Extract and Hypericum Perforatum Oil
St. John's Wort extract and oil safety in cosmetics is unclear; more data needed on photosensitization, toxicity, and human irritation.
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research Comorbid Conditions in Lichen Planopilaris: A Retrospective Data Analysis of 334 Patients
People with Lichen planopilaris are more likely to have certain autoimmune and endocrine disorders but less likely to have conditions like allergies and diabetes.
research Prophylaxis and Management of Skin Toxicities
Preventive measures and effective management are crucial for reducing skin side effects in cancer treatment.
research Expert Recommendations on Supportive Skin Care for Non-Surgical and Surgical Procedures
Experts advise using sunscreen and proper skin care before, during, and after procedures to speed healing, prevent complications, and reduce scarring.
research Development and Skin Penetration Pathway Evaluation Using Confocal Laser Scanning Microscopy of Microemulsions for Dermal Delivery Enhancement of Finasteride
Finasteride-loaded microemulsions can effectively enhance skin delivery for treating hair loss.
research Amino Acids Oral Treatment for the Amelioration of Skin, Hair, and Nails Conditions: An Open-Label Study
Taking an amino acid supplement improved skin, hair, and nail health in women.
research DNA Damage-Inducible Transcript 4 Is an Innate Surveillant of Hair Follicular Stress in Vitamin D Receptor Knockout Mice and a Regulator of Wound Re-Epithelialization
Vitamin D receptor is important for regulating hair growth and wound healing in mice.
research Elevated Ornithine Decarboxylase Activity Promotes Skin Tumorigenesis by Stimulating the Recruitment of Bulge Stem Cells but Not via Toxic Polyamine Catabolic Metabolites
The study investigated the role of elevated ornithine decarboxylase (ODC) activity in skin tumorigenesis, particularly its effect on bulge stem cells and polyamine catabolic metabolites, using ODC-ER transgenic mice. It was found that increased ODC activity promoted skin tumor development by recruiting bulge stem cells, which are associated with hair follicles, rather than through the generation of reactive oxygen species (ROS) by polyamine catabolic oxidases. Inhibiting polyamine catabolic oxidase activity with MDL72527 resulted in a shorter tumor latency, increased tumor burden, and higher conversion to carcinomas, indicating that the tumorigenic effect was not due to ROS generation. The findings suggested that targeting ODC activity could be a potential strategy for preventing skin tumorigenesis by affecting stem cell dynamics rather than through the toxicity of polyamine breakdown products.
research WWOX Deficiency Causes Downregulation of Prosurvival ERK Signaling and Abnormal Homeostatic Responses in Mouse Skin
WWOX deficiency in mice causes skin and fat tissue problems due to disrupted cell survival signals.
research Epithelial-Mesenchymal Interaction in Hair Regeneration and Skin Wound Healing
Hair and skin healing involve complex cell interactions controlled by specific molecules and pathways, and hair follicle cells can help repair skin wounds.
research Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin
Special proteins are important for skin balance, healing, and aging, and affect skin stem cells.
research Protein Carbonylation As A Reliable Read-Out Of Urban Pollution Damage/Protection Of Hair Fibers
research Reversible Activation of c-Myc in Skin
The study explored the effects of activating the protooncogene c-Myc in the skin of transgenic mice, revealing that c-Myc activation led to rapid proliferation and disrupted differentiation of keratinocytes, resulting in conditions resembling precancerous lesions such as hyperplastic actinic keratosis. These changes were accompanied by angiogenesis and were reversible upon deactivation of c-Myc. Despite the potential for c-Myc to induce apoptosis, survival signals in the skin suppressed this effect, allowing for the development of benign, hyperproliferative lesions without progressing to malignancy. The study highlighted the role of c-Myc in skin homeostasis and its implications in skin carcinogenesis, suggesting that additional mutations would be necessary for malignant transformation.
research Autophagy: Guardian of Skin Barrier
Autophagy helps keep skin healthy and may improve treatments for skin diseases.
research Skin Microbiome, Metabolome and Skin Phenome, from the Perspectives of Skin as an Ecosystem
Your skin is like an ecosystem, with its own community of microbes and substances that interact and affect its health.
research Effects of Natural Products on Skin Inflammation Caused by Abnormal Hormones Secreted by the Adrenal Gland
Natural products may help treat skin inflammation from abnormal adrenal hormones.
research Skin Manifestations of Rheumatological Diseases
Different rheumatological diseases can cause specific skin problems.
research Duo-Role Platelet-Rich Plasma: Temperature-Induced Fibrin Gel and Growth Factors' Reservoir for Microneedles to Promote Hair Regrowth
A new method using Platelet-rich Plasma (PRP) in a microneedle can promote hair regrowth more efficiently and is painless, minimally invasive, and affordable.
research Blue Laser Irradiation Decreases ATP Levels in Mouse Skin and Increases Production of Superoxide Anion and Hypochlorous Acid in Mouse Fibroblasts
Blue laser light reduces energy in mouse skin cells and creates harmful oxygen compounds, possibly harming the cells.
research An Advanced Review: Polyurethane-Related Dressings for Skin Wound Repair
Polyurethane dressings show promise for wound healing but need improvements to adapt better to the healing process.
research Exosomal MicroRNA-Based Therapies for Skin Diseases
miRNA-based therapies show promise for treating skin diseases, including hair loss, in animals.
research In Vitro, Ex Vivo, and Clinical Evaluation of Anti-Aging Gel Containing EPA and CBD
The gel with CBD and EPA reduced wrinkles, improved skin hydration and elasticity, and had strong anti-aging effects.
research Therapeutic Use of Caffeine in Dermatology: A Literature Review
Caffeine may benefit skin and hair health but more research is needed to confirm its effectiveness in dermatology.
research Blue Light in Dermatology
Blue light can help treat skin conditions like eczema and acne without major side effects.
research Spreading of Isolated Ptch Mutant Basal Cell Carcinoma Precursors Is Physiologically Suppressed and Counteracts Tumor Formation in Mice
External factors can cause skin cancer cells that usually don't spread to grow and form tumors in mice.
research p53 Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a Rat Model of Radiation Dermatitis
The protein p53 directly reduces the production of Keratin 17, a skin and hair protein, in rats with radiation dermatitis.
research A Review of the Most Common Dermatologic Conditions and Their Debilitating Psychosocial Impacts
Common skin conditions can greatly affect a person's mental health and social life.
research Cell-Based Model Systems for Validation of Efficacy Claims for Cosmetic Ingredients
Cell-based models help test if cosmetic ingredients really work for hair growth and skin health.
research Annual Convention in the Time of COVID: The 2020 Dermatology Nurses' Association Meeting
The convention discussed various skin conditions and treatments, and highlighted the importance of vaccinations for patients on immune-altering medications.
research Perilla Frutescens: A Rich Source of Pharmacologically Active Compounds
Perilla frutescens, an East Asian plant, contains 400 bioactive compounds that have various health benefits, including anti-inflammatory, antidepressant, and anticancer effects, and can treat conditions like diabetes, skin allergies, and neurological disorders.